WNT3A [The Human Chemical-Genetic Interaction Map Project]

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======= WNT3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT3A
  * **<color #00a2e8>Official Name</color>**: Wnt family member 3A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=89780|89780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56704|P56704]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606359|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). {ECO:0000250|UniProtKB:P27467, ECO:0000269|PubMed:20093360, ECO:0000269|PubMed:21244856, ECO:0000269|PubMed:24841207, ECO:0000269|PubMed:26902720, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation|
|regulation of cardioblast cell fate specification|
|negative regulation of cardioblast cell fate specification|
|calcium ion transmembrane transport via low voltage-gated calcium channel|
|negative regulation of cardiac cell fate specification|
|positive regulation of mesodermal cell differentiation|
|positive regulation of mesodermal cell fate specification|
|negative regulation of heart induction by canonical Wnt signaling pathway|
|positive regulation of mesoderm formation|
|Wnt signaling pathway involved in forebrain neuroblast division|
|negative regulation of heart induction|
|regulation of heart induction by canonical Wnt signaling pathway|
|negative regulation of cardioblast differentiation|
|positive regulation of cell fate specification|
|paraxial mesodermal cell differentiation|
|canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|
|regulation of cardiac cell fate specification|
|regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation|
|paraxial mesodermal cell fate commitment|
|positive regulation of collateral sprouting in absence of injury|
|positive regulation of dermatome development|
|canonical Wnt signaling pathway involved in heart development|
|negative regulation of dopaminergic neuron differentiation|
|regulation of collateral sprouting in absence of injury|
|Wnt-Frizzled-LRP5/6 complex|
|axis elongation involved in somitogenesis|
|regulation of dermatome development|
|positive regulation of mesoderm development|
|COP9 signalosome assembly|
|Wnt signaling pathway involved in heart development|
|cell proliferation in midbrain|
|regulation of heart induction|
|negative regulation of cell fate specification|
|cardiac muscle cell fate commitment|
|paraxial mesoderm formation|
|regulation of mesodermal cell differentiation|
|positive regulation of core promoter binding|
|regulation of mesodermal cell fate specification|
|regulation of mesoderm formation|
|regulation of core promoter binding|
|regulation of cardioblast differentiation|
|positive regulation of hepatocyte proliferation|
|positive regulation of gastrulation|
|forebrain neuroblast division|
|positive regulation of cell fate commitment|
|postsynapse to nucleus signaling pathway|
|paraxial mesoderm morphogenesis|
|regulation of dopaminergic neuron differentiation|
|cardiac cell fate commitment|
|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|positive regulation of cell-cell adhesion mediated by cadherin|
|positive regulation of collateral sprouting|
|midbrain dopaminergic neuron differentiation|
|regulation of cell fate specification|
|negative regulation of cell fate commitment|
|co-receptor binding|
|regulation of type B pancreatic cell proliferation|
|mesodermal cell fate commitment|
|regulation of hepatocyte proliferation|
|spinal cord association neuron differentiation|
|muscle cell fate commitment|
|neuroblast division|
|neuronal stem cell division|
|dorsal/ventral neural tube patterning|
|regulation of mesoderm development|
|regulation of cell-cell adhesion mediated by cadherin|
|paraxial mesoderm development|
|post-anal tail morphogenesis|
|presynapse assembly|
|positive regulation of cardiac muscle cell differentiation|
|regulation of collateral sprouting|
|negative regulation of stem cell differentiation|
|beta-catenin destruction complex disassembly|
|negative regulation of cardiocyte differentiation|
|presynapse organization|
|dorsal spinal cord development|
|somatic stem cell division|
|cell surface receptor signaling pathway involved in heart development|
|secondary palate development|
|positive regulation of receptor internalization|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of skeletal muscle tissue development|
|negative regulation of axon extension involved in axon guidance|
|mesodermal cell differentiation|
|axis elongation|
|cell proliferation in forebrain|
|cell fate commitment involved in formation of primary germ layer|
|negative regulation of axon guidance|
|regulation of cell fate commitment|
|positive regulation of cardiocyte differentiation|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|dopaminergic neuron differentiation|
|neuroblast proliferation|
|regulation of axon extension involved in axon guidance|
|stem cell division|
|receptor ligand activity|
|neural tube patterning|
|regulation of cardiac muscle cell differentiation|
|regulation of animal organ formation|
|positive regulation of embryonic development|
|regulation of gastrulation|
|postsynaptic signal transduction|
|frizzled binding|
|regulation of heart morphogenesis|
|positive regulation of B cell proliferation|
|negative regulation of axon extension|
|positive regulation of cardiac muscle tissue development|
|regulation of axon guidance|
|platelet aggregation|
|negative regulation of fat cell differentiation|
|regulation of skeletal muscle tissue development|
|skeletal muscle cell differentiation|
|mesenchyme morphogenesis|
|regulation of cardiocyte differentiation|
|synaptic vesicle recycling|
|positive regulation of receptor-mediated endocytosis|
|regulation of transcription regulatory region DNA binding|
|positive regulation of neural precursor cell proliferation|
|stem cell proliferation|
|cell differentiation in spinal cord|
|regulation of receptor internalization|
|positive regulation of protein localization to plasma membrane|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of DNA binding|
|negative regulation of chemotaxis|
|positive regulation of striated muscle cell differentiation|
|homotypic cell-cell adhesion|
|heart looping|
|regulation of B cell proliferation|
|positive regulation of protein localization to cell periphery|
|somitogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|forebrain generation of neurons|
|mesoderm formation|
|endocytic vesicle membrane|
|negative regulation of axonogenesis|
|mesoderm morphogenesis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|cellular response to retinoic acid|
|positive regulation of muscle tissue development|
|neural precursor cell proliferation|
|embryonic heart tube development|
|regulation of cardiac muscle tissue development|
|positive regulation of animal organ morphogenesis|
|hippocampus development|
|dorsal/ventral pattern formation|
|somite development|
|midbrain development|
|positive regulation of axonogenesis|
|positive regulation of muscle cell differentiation|
|cardiac muscle cell differentiation|
|regulation of neural precursor cell proliferation|
|regulation of protein tyrosine kinase activity|
|canonical Wnt signaling pathway|
|roof of mouth development|
|synapse assembly|
|positive regulation of protein binding|
|presynapse|
|regulation of protein localization to plasma membrane|
|segmentation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|inner ear morphogenesis|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|Golgi lumen|
|regulation of striated muscle cell differentiation|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of synapse assembly|
|negative regulation of developmental growth|
|spinal cord development|
|response to retinoic acid|
|limbic system development|
|regulation of extent of cell growth|
|formation of primary germ layer|
|developmental growth involved in morphogenesis|
|regulation of protein localization to cell periphery|
|cardiocyte differentiation|
|regulation of stem cell differentiation|
|ear morphogenesis|
|determination of left/right symmetry|
|synaptic vesicle cycle|
|regulation of fat cell differentiation|
|positive regulation of protein localization to membrane|
|skeletal muscle tissue development|
|determination of bilateral symmetry|
|specification of symmetry|
|mesoderm development|
|regulation of DNA binding|
|osteoblast differentiation|
|mammary gland development|
|regulation of embryonic development|
|vesicle-mediated transport in synapse|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of leukocyte proliferation|
|regulation of peptidyl-serine phosphorylation|
|platelet activation|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of cysteine-type endopeptidase activity|
|early endosome membrane|
|regulation of muscle cell differentiation|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|gastrulation|
|neural tube development|
|cardiac muscle tissue development|
|positive regulation of cell growth|
|positive regulation of B cell activation|
|positive regulation of developmental growth|
|positive regulation of endopeptidase activity|
|pallium development|
|positive regulation of Wnt signaling pathway|
|positive regulation of binding|
|central nervous system neuron differentiation|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|positive regulation of epithelial cell proliferation|
|regulation of protein localization to membrane|
|regulation of microtubule cytoskeleton organization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of peptidase activity|
|inner ear development|
|calcium ion transmembrane transport|
|striated muscle cell differentiation|
|regulation of endocytosis|
|negative regulation of neuron death|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|cellular response to acid chemical|
|regulation of mononuclear cell proliferation|
|regulation of chemotaxis|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|anterior/posterior pattern specification|
|regulation of synapse organization|
|regulation of protein binding|
|ear development|
|mesenchyme development|
|regulation of leukocyte proliferation|
|regulation of microtubule-based process|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|protein-containing complex disassembly|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|protein domain specific binding|
|muscle cell differentiation|
|cell fate commitment|
|calcium ion transport|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|telencephalon development|
|positive regulation of growth|
|axon guidance|
|positive regulation of DNA-binding transcription factor activity|
|ossification|
|neuron projection guidance|
|synapse organization|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|blood coagulation|
|coagulation|
|muscle organ development|
|divalent metal ion transport|
|muscle tissue development|
|hemostasis|
|divalent inorganic cation transport|
|endoplasmic reticulum lumen|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of neuron death|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|regulation of developmental growth|
|regionalization|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|signaling receptor binding|
|extracellular matrix organization|
|response to acid chemical|
|glutamatergic synapse|
|Wnt signaling pathway|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|positive regulation of lymphocyte activation|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|axonogenesis|
|in utero embryonic development|
|regulation of binding|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|extracellular structure organization|
|forebrain development|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|cellular component disassembly|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|axon development|
|gland development|
|regulation of cell growth|
|regulation of endopeptidase activity|
|positive regulation of cell activation|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|synaptic signaling|
|positive regulation of neurogenesis|
|muscle structure development|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|cell division|
|regulation of neuron projection development|
|regulation of body fluid levels|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|regulation of anatomical structure size|
|cellular response to lipid|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|sensory organ development|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|cell population proliferation|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|inorganic cation transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|cell surface|
|chordate embryonic development|
|metal ion transport|
|regulation of cell activation|
|positive regulation of apoptotic process|
|inorganic ion transmembrane transport|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of proteolysis|
|brain development|
|positive regulation of hydrolase activity|
|head development|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cation transport|
|cellular protein-containing complex assembly|
|tube development|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|ion transmembrane transport|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|transmembrane transport|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.07|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.89|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.85|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.79|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.79|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.75|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.71|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.73|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13470
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT3A Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>