WNT7B [The Human Chemical-Genetic Interaction Map Project]

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======= WNT7B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT7B
  * **<color #00a2e8>Official Name</color>**: Wnt family member 7B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7477|7477]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56706|P56706]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT7B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT7B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601967|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway in vascular smooth muscle cells. Required for normal fusion of the chorion and the allantois during placenta development. {ECO:0000250|UniProtKB:P28047}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|outer medullary collecting duct development|
|establishment or maintenance of polarity of embryonic epithelium|
|renal inner medulla development|
|fibroblast proliferation|
|renal outer medulla development|
|inner medullary collecting duct development|
|central nervous system vasculogenesis|
|establishment of endothelial blood-brain barrier|
|trachea cartilage morphogenesis|
|metanephric loop of Henle development|
|lobar bronchus development|
|establishment of blood-brain barrier|
|chorio-allantoic fusion|
|oxygen homeostasis|
|trachea cartilage development|
|metanephric collecting duct development|
|bronchus development|
|gas homeostasis|
|loop of Henle development|
|trachea morphogenesis|
|collecting duct development|
|regulation of cell projection size|
|lens fiber cell development|
|metanephric nephron tubule development|
|metanephric nephron epithelium development|
|metanephric tubule development|
|trachea development|
|labyrinthine layer morphogenesis|
|metanephric epithelium development|
|forebrain regionalization|
|embryonic placenta morphogenesis|
|metanephros morphogenesis|
|lens fiber cell differentiation|
|cartilage morphogenesis|
|lung epithelium development|
|establishment of endothelial barrier|
|receptor ligand activity|
|activation of JUN kinase activity|
|frizzled binding|
|lung morphogenesis|
|labyrinthine layer development|
|endothelial cell development|
|stem cell proliferation|
|positive regulation of osteoblast differentiation|
|mammary gland epithelium development|
|endocytic vesicle membrane|
|vasculogenesis|
|cellular response to retinoic acid|
|positive regulation of JUN kinase activity|
|lens development in camera-type eye|
|nephron tubule development|
|renal tubule development|
|JNK cascade|
|endothelial cell differentiation|
|metanephros development|
|kidney morphogenesis|
|positive regulation of ossification|
|regulation of JUN kinase activity|
|embryonic placenta development|
|canonical Wnt signaling pathway|
|endothelium development|
|nephron epithelium development|
|Golgi lumen|
|stress-activated MAPK cascade|
|response to retinoic acid|
|regulation of osteoblast differentiation|
|developmental growth involved in morphogenesis|
|nephron development|
|mammary gland development|
|kidney epithelium development|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|morphogenesis of embryonic epithelium|
|response to glucocorticoid|
|placenta development|
|activation of MAPK activity|
|response to corticosteroid|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|lung development|
|cartilage development|
|respiratory tube development|
|regulation of JNK cascade|
|regulation of ossification|
|epithelial cell development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|cellular response to acid chemical|
|connective tissue development|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cell fate commitment|
|positive regulation of MAP kinase activity|
|kidney development|
|synapse organization|
|renal system development|
|endoplasmic reticulum lumen|
|camera-type eye development|
|urogenital system development|
|response to steroid hormone|
|activation of protein kinase activity|
|regionalization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|sensory system development|
|MAPK cascade|
|regulation of cellular component size|
|in utero embryonic development|
|forebrain development|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|blood vessel morphogenesis|
|gland development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|skeletal system development|
|cell-cell adhesion|
|vasculature development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|neuron projection development|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|cell morphogenesis|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|tube development|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|response to hormone|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.483|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11105
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT7B Expression in NALM6 Cells: 1.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>