WTH3DI [The Human Chemical-Genetic Interaction Map Project]

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======= WTH3DI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAB6D
  * **<color #00a2e8>Official Name</color>**: RAB6D, member RAS oncogene family
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=150786|150786]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53S08|Q53S08]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WTH3DI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WTH3DI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intra-Golgi vesicle-mediated transport|
|Rab protein signal transduction|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|retrograde transport, endosome to Golgi|
|cytosolic transport|
|endosomal transport|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|GTPase activity|
|Golgi vesicle transport|
|GTP binding|
|Golgi apparatus|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.09|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.97|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.84|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-1.82|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10537
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: N/A 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAB6D Expression in NALM6 Cells: N/A'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>