WWOX [The Human Chemical-Genetic Interaction Map Project]

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======= WWOX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WWOX
  * **<color #00a2e8>Official Name</color>**: WW domain containing oxidoreductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51741|51741]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZC7|Q9NZC7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WWOX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WWOX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605131|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|adh short|
|KR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|coenzyme binding|
|cofactor binding|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of extrinsic apoptotic signaling pathway|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|microvillus|
|RNA polymerase II transcription factor complex|
|extrinsic apoptotic signaling pathway|
|oxidoreductase activity|
|signal transduction by p53 class mediator|
|osteoblast differentiation|
|intrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to transforming growth factor beta stimulus|
|protein dimerization activity|
|response to transforming growth factor beta|
|positive regulation of apoptotic signaling pathway|
|negative regulation of Wnt signaling pathway|
|skeletal system morphogenesis|
|steroid metabolic process|
|ossification|
|transcription coactivator activity|
|apoptotic signaling pathway|
|enzyme binding|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|regulation of apoptotic signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|skeletal system development|
|cellular response to growth factor stimulus|
|response to growth factor|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|negative regulation of transcription by RNA polymerase II|
|apoptotic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|Golgi apparatus|
|programmed cell death|
|cell death|
|cell-cell signaling|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.28|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.04|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.97|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.8|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.77|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.73|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17823
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WWOX Expression in NALM6 Cells: 3.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>