WWP2 [The Human Chemical-Genetic Interaction Map Project]

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======= WWP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WWP2
  * **<color #00a2e8>Official Name</color>**: WW domain containing E3 ubiquitin protein ligase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11060|11060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00308|O00308]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WWP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WWP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602308|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|HECT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellular transport|
|protein K63-linked ubiquitination|
|negative regulation of Notch signaling pathway|
|regulation of potassium ion transmembrane transporter activity|
|RNA polymerase II transcription factor binding|
|protein autoubiquitination|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|viral entry into host cell|
|regulation of potassium ion transport|
|entry into host cell|
|regulation of Notch signaling pathway|
|entry into host|
|ubiquitin ligase complex|
|interaction with host|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|viral life cycle|
|positive regulation of protein catabolic process|
|ubiquitin protein ligase activity|
|ubiquitin-protein transferase activity|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|transcription factor binding|
|regulation of cation transmembrane transport|
|proteasomal protein catabolic process|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|positive regulation of catabolic process|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|regulation of transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of ion transport|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18250
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WWP2 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>