XCL1 [The Human Chemical-Genetic Interaction Map Project]

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======= XCL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XCL1
  * **<color #00a2e8>Official Name</color>**: X-C motif chemokine ligand 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6375|6375]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47992|P47992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XCL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XCL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. {ECO:0000250|UniProtKB:P47993}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of granzyme A production|
|negative regulation of T-helper 1 cell activation|
|regulation of T-helper 1 cell activation|
|regulation of granzyme A production|
|mature natural killer cell chemotaxis|
|positive regulation of CD8-positive, alpha-beta T cell proliferation|
|regulation of immunoglobulin production in mucosal tissue|
|positive regulation of B cell chemotaxis|
|regulation of granzyme B production|
|positive regulation of immunoglobulin production in mucosal tissue|
|positive regulation of granzyme B production|
|regulation of B cell chemotaxis|
|natural killer cell chemotaxis|
|positive regulation of thymocyte migration|
|regulation of thymocyte migration|
|regulation of T-helper 1 cell cytokine production|
|positive regulation of CD4-positive, alpha-beta T cell proliferation|
|positive regulation of T-helper 1 cell cytokine production|
|positive regulation of natural killer cell chemotaxis|
|regulation of CD8-positive, alpha-beta T cell proliferation|
|positive regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of T-helper 1 type immune response|
|positive regulation of T-helper 2 cell cytokine production|
|chemokine receptor binding|
|negative regulation of CD4-positive, alpha-beta T cell proliferation|
|regulation of natural killer cell chemotaxis|
|negative regulation of T cell cytokine production|
|negative regulation of alpha-beta T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|regulation of T-helper 2 cell cytokine production|
|regulation of CD8-positive, alpha-beta T cell activation|
|positive regulation of type 2 immune response|
|positive regulation of T cell chemotaxis|
|regulation of T cell chemotaxis|
|negative regulation of T cell mediated immunity|
|positive regulation of alpha-beta T cell proliferation|
|positive regulation of T cell cytokine production|
|positive regulation of transforming growth factor beta production|
|positive regulation of T-helper 1 type immune response|
|positive regulation of lymphocyte chemotaxis|
|negative regulation of interleukin-2 production|
|positive regulation of neutrophil chemotaxis|
|negative regulation of cytokine production involved in immune response|
|regulation of lymphocyte chemotaxis|
|positive regulation of granulocyte chemotaxis|
|positive regulation of T cell mediated cytotoxicity|
|regulation of T-helper 1 type immune response|
|cellular response to interleukin-4|
|CCR chemokine receptor binding|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of neutrophil chemotaxis|
|positive regulation of neutrophil migration|
|regulation of type 2 immune response|
|regulation of alpha-beta T cell proliferation|
|response to interleukin-4|
|regulation of T cell cytokine production|
|positive regulation of T cell migration|
|regulation of T cell mediated cytotoxicity|
|negative regulation of interferon-gamma production|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of production of molecular mediator of immune response|
|regulation of transforming growth factor beta production|
|positive regulation of interleukin-10 production|
|regulation of neutrophil migration|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|positive regulation of lymphocyte migration|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of alpha-beta T cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of release of sequestered calcium ion into cytosol|
|monocyte chemotaxis|
|positive regulation of immunoglobulin production|
|regulation of granulocyte chemotaxis|
|regulation of T cell migration|
|negative regulation of adaptive immune response|
|lymphocyte chemotaxis|
|positive regulation of T cell mediated immunity|
|mononuclear cell migration|
|negative regulation of leukocyte mediated immunity|
|chemokine activity|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of interleukin-10 production|
|positive regulation of cytokine production involved in immune response|
|positive regulation of calcium ion transport into cytosol|
|regulation of interleukin-2 production|
|release of sequestered calcium ion into cytosol|
|positive regulation of leukocyte mediated cytotoxicity|
|negative regulation of sequestering of calcium ion|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|negative regulation of T cell proliferation|
|regulation of lymphocyte migration|
|regulation of immunoglobulin production|
|calcium ion transmembrane import into cytosol|
|lymphocyte migration|
|positive regulation of cell killing|
|positive regulation of calcium ion transmembrane transport|
|regulation of T cell mediated immunity|
|calcium ion transport into cytosol|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|regulation of leukocyte mediated cytotoxicity|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of leukocyte proliferation|
|chemokine-mediated signaling pathway|
|cell|
|neutrophil chemotaxis|
|regulation of cytokine production involved in immune response|
|positive regulation of leukocyte chemotaxis|
|cytosolic calcium ion transport|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|regulation of calcium ion transport into cytosol|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|granulocyte migration|
|regulation of cell killing|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|negative regulation of T cell activation|
|regulation of leukocyte chemotaxis|
|negative regulation of immune effector process|
|positive regulation of calcium ion transport|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of sequestering of calcium ion|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of production of molecular mediator of immune response|
|positive regulation of cation transmembrane transport|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte chemotaxis|
|negative regulation of lymphocyte activation|
|regulation of calcium ion transmembrane transport|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|positive regulation of ion transmembrane transport|
|cellular response to transforming growth factor beta stimulus|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|negative regulation of DNA-binding transcription factor activity|
|cellular response to interferon-gamma|
|response to transforming growth factor beta|
|negative regulation of leukocyte activation|
|cellular response to interleukin-1|
|negative regulation of cell-cell adhesion|
|response to interferon-gamma|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|calcium ion transmembrane transport|
|response to interleukin-1|
|positive regulation of transmembrane transport|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|cellular response to tumor necrosis factor|
|regulation of calcium ion transport|
|calcium ion transport|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|response to virus|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|regulation of leukocyte cell-cell adhesion|
|divalent inorganic cation transport|
|regulation of T cell activation|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of immune effector process|
|regulation of ion transmembrane transport|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|regulation of cell migration|
|positive regulation of immune response|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|ion transmembrane transport|
|defense response to other organism|
|cell migration|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|transmembrane transport|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12420
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XCL1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>