XPNPEP3 [The Human Chemical-Genetic Interaction Map Project]

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======= XPNPEP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPNPEP3
  * **<color #00a2e8>Official Name</color>**: X-prolyl aminopeptidase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63929|63929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQH7|Q9NQH7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPNPEP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPNPEP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613553|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M24|
|AMP N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glomerular filtration|
|renal filtration|
|metalloaminopeptidase activity|
|aminopeptidase activity|
|manganese ion binding|
|renal system process|
|protein processing|
|protein maturation|
|protein homodimerization activity|
|mitochondrion|
|proteolysis|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.7|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.71|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.74|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.74|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.77|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.78|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.78|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.8|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.8|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.81|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.86|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.92|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.92|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.94|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.96|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.06|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.18|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.28|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.3|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.42|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.48|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rmnd1|RMND1]]|0.565|
|[[:human genes:p:pet117|PET117]]|0.55|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.543|
|[[:human genes:p:prepl|PREPL]]|0.542|
|[[:human genes:p:pde12|PDE12]]|0.537|
|[[:human genes:e:eral1|ERAL1]]|0.533|
|[[:human genes:f:fastkd2|FASTKD2]]|0.531|
|[[:human genes:p:pet112|PET112]]|0.529|
|[[:human genes:m:mtif2|MTIF2]]|0.516|
|[[:human genes:d:ddx28|DDX28]]|0.514|
|[[:human genes:c:cox6a1|COX6A1]]|0.512|
|[[:human genes:m:mcur1|MCUR1]]|0.508|
|[[:human genes:m:malsu1|MALSU1]]|0.481|
|[[:human genes:s:slc30a9|SLC30A9]]|0.48|
|[[:human genes:m:mrpl1|MRPL1]]|0.479|
|[[:human genes:n:ndufb10|NDUFB10]]|0.478|
|[[:human genes:n:nsun4|NSUN4]]|0.477|
|[[:human genes:t:tsfm|TSFM]]|0.477|
|[[:human genes:f:ftsj2|FTSJ2]]|0.475|
|[[:human genes:p:ptcd3|PTCD3]]|0.458|
|[[:human genes:m:mrps27|MRPS27]]|0.457|
|[[:human genes:t:tfb1m|TFB1M]]|0.455|
|[[:human genes:n:ndufs2|NDUFS2]]|0.454|
|[[:human genes:c:clpp|CLPP]]|0.452|
|[[:human genes:m:mettl17|METTL17]]|0.452|
|[[:human genes:r:rexo2|REXO2]]|0.45|
|[[:human genes:t:trit1|TRIT1]]|0.448|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.447|
|[[:human genes:i:ict1|ICT1]]|0.442|
|[[:human genes:w:wars2|WARS2]]|0.439|
|[[:human genes:a:acad9|ACAD9]]|0.438|
|[[:human genes:m:mrps31|MRPS31]]|0.436|
|[[:human genes:a:aars2|AARS2]]|0.435|
|[[:human genes:c:cox8a|COX8A]]|0.434|
|[[:human genes:c:clpx|CLPX]]|0.432|
|[[:human genes:m:mrps18b|MRPS18B]]|0.431|
|[[:human genes:n:nubpl|NUBPL]]|0.431|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.427|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.426|
|[[:human genes:m:mterfd1|MTERFD1]]|0.425|
|[[:human genes:c:coa3|COA3]]|0.425|
|[[:human genes:q:qrsl1|QRSL1]]|0.423|
|[[:human genes:m:mrpl30|MRPL30]]|0.42|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.418|
|[[:human genes:r:rpusd3|RPUSD3]]|0.417|
|[[:human genes:s:slc25a51|SLC25A51]]|0.416|
|[[:human genes:n:ndufv2|NDUFV2]]|0.416|
|[[:human genes:m:mrpl49|MRPL49]]|0.414|
|[[:human genes:c:ccdc90b|CCDC90B]]|0.414|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.412|
|[[:human genes:n:ndufb4|NDUFB4]]|0.411|
|[[:human genes:n:nars2|NARS2]]|0.411|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.41|
|[[:human genes:m:mrps35|MRPS35]]|0.406|
|[[:human genes:c:cox18|COX18]]|0.403|
|[[:human genes:m:mrpl45|MRPL45]]|0.403|
|[[:human genes:c:cars2|CARS2]]|0.401|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.401|
|[[:human genes:p:pdss2|PDSS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPNPEP3 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>