XYLT2 [The Human Chemical-Genetic Interaction Map Project]

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======= XYLT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XYLT2
  * **<color #00a2e8>Official Name</color>**: xylosyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64132|64132]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1B5|Q9H1B5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XYLT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XYLT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans (PubMed:26027496). Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated. {ECO:0000250|UniProtKB:Q86Y38, ECO:0000269|PubMed:26027496}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Branch|
|Xylo C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein xylosyltransferase activity|
|heparin biosynthetic process|
|heparin metabolic process|
|acetylglucosaminyltransferase activity|
|chondroitin sulfate biosynthetic process|
|heparan sulfate proteoglycan biosynthetic process|
|chondroitin sulfate proteoglycan biosynthetic process|
|heparan sulfate proteoglycan metabolic process|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|manganese ion binding|
|proteoglycan biosynthetic process|
|proteoglycan metabolic process|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|sulfur compound biosynthetic process|
|magnesium ion binding|
|glycoprotein biosynthetic process|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|extracellular space|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.32|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.7|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.545|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.513|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.511|
|[[:human genes:c:chd4|CHD4]]|0.51|
|[[:human genes:s:snrpa1|SNRPA1]]|0.506|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.503|
|[[:human genes:a:acsf2|ACSF2]]|0.495|
|[[:human genes:i:ik|IK]]|0.49|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.484|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.484|
|[[:human genes:n:nupl1|NUPL1]]|0.484|
|[[:human genes:p:psmb4|PSMB4]]|0.48|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.474|
|[[:human genes:l:lrr1|LRR1]]|0.472|
|[[:human genes:m:mt1e|MT1E]]|0.471|
|[[:human genes:r:rps12|RPS12]]|0.468|
|[[:human genes:c:ccna2|CCNA2]]|0.464|
|[[:human genes:a:ankle2|ANKLE2]]|0.462|
|[[:human genes:d:dtl|DTL]]|0.462|
|[[:human genes:k:kctd17|KCTD17]]|0.46|
|[[:human genes:c:chaf1a|CHAF1A]]|0.458|
|[[:human genes:t:tsg101|TSG101]]|0.457|
|[[:human genes:v:vasn|VASN]]|0.456|
|[[:human genes:p:psmc1|PSMC1]]|0.456|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.455|
|[[:human genes:p:parp3|PARP3]]|0.452|
|[[:human genes:n:narfl|NARFL]]|0.449|
|[[:human genes:p:paf1|PAF1]]|0.449|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.446|
|[[:human genes:d:dhx38|DHX38]]|0.445|
|[[:human genes:m:mbtd1|MBTD1]]|0.444|
|[[:human genes:u:utp3|UTP3]]|0.443|
|[[:human genes:p:psmd11|PSMD11]]|0.443|
|[[:human genes:c:cdt1|CDT1]]|0.443|
|[[:human genes:r:rps19|RPS19]]|0.443|
|[[:human genes:r:rbm39|RBM39]]|0.443|
|[[:human genes:r:rps2|RPS2]]|0.442|
|[[:human genes:p:pan3|PAN3]]|0.442|
|[[:human genes:c:ccdc116|CCDC116]]|0.439|
|[[:human genes:r:rpl35|RPL35]]|0.438|
|[[:human genes:s:supt5h|SUPT5H]]|0.438|
|[[:human genes:s:sap30bp|SAP30BP]]|0.437|
|[[:human genes:s:snip1|SNIP1]]|0.437|
|[[:human genes:o:orc6|ORC6]]|0.437|
|[[:human genes:a:aamp|AAMP]]|0.437|
|[[:human genes:o:orc1|ORC1]]|0.437|
|[[:human genes:d:ddtl|DDTL]]|0.436|
|[[:human genes:d:dock6|DOCK6]]|0.436|
|[[:human genes:c:cgb2|CGB2]]|0.435|
|[[:human genes:c:cdc73|CDC73]]|0.434|
|[[:human genes:p:pole|POLE]]|0.434|
|[[:human genes:p:psmc2|PSMC2]]|0.433|
|[[:human genes:n:nol10|NOL10]]|0.432|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.432|
|[[:human genes:p:ppfia4|PPFIA4]]|0.43|
|[[:human genes:t:terf1|TERF1]]|0.43|
|[[:human genes:g:gar1|GAR1]]|0.43|
|[[:human genes:p:psmb3|PSMB3]]|0.43|
|[[:human genes:t:tfip11|TFIP11]]|0.429|
|[[:human genes:s:slc4a1|SLC4A1]]|0.427|
|[[:human genes:n:nop16|NOP16]]|0.427|
|[[:human genes:e:exosc3|EXOSC3]]|0.427|
|[[:human genes:p:polr2a|POLR2A]]|0.426|
|[[:human genes:s:smg7|SMG7]]|0.426|
|[[:human genes:i:igfn1|IGFN1]]|0.426|
|[[:human genes:c:cdca3|CDCA3]]|0.425|
|[[:human genes:k:krt78|KRT78]]|0.425|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.424|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.424|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.424|
|[[:human genes:i:iscu|ISCU]]|0.424|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.423|
|[[:human genes:c:cln6|CLN6]]|0.423|
|[[:human genes:i:ints5|INTS5]]|0.423|
|[[:human genes:p:psma6|PSMA6]]|0.422|
|[[:human genes:c:ctr9|CTR9]]|0.421|
|[[:human genes:o:or10g3|OR10G3]]|0.42|
|[[:human genes:r:rilpl1|RILPL1]]|0.42|
|[[:human genes:e:exosc9|EXOSC9]]|0.418|
|[[:human genes:k:kpnb1|KPNB1]]|0.417|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.417|
|[[:human genes:r:rps28|RPS28]]|0.417|
|[[:human genes:r:rrn3|RRN3]]|0.416|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.415|
|[[:human genes:p:ppm1d|PPM1D]]|0.415|
|[[:human genes:n:ndc80|NDC80]]|0.414|
|[[:human genes:p:psmd3|PSMD3]]|0.414|
|[[:human genes:p:psmd1|PSMD1]]|0.414|
|[[:human genes:n:nup133|NUP133]]|0.414|
|[[:human genes:a:acbd4|ACBD4]]|0.414|
|[[:human genes:l:loc643669|LOC643669]]|0.413|
|[[:human genes:r:rpl7a|RPL7A]]|0.413|
|[[:human genes:p:pold1|POLD1]]|0.413|
|[[:human genes:c:cope|COPE]]|0.412|
|[[:human genes:t:tspy8|TSPY8]]|0.412|
|[[:human genes:t:terf2|TERF2]]|0.412|
|[[:human genes:a:art5|ART5]]|0.409|
|[[:human genes:p:prpf3|PRPF3]]|0.408|
|[[:human genes:t:twistnb|TWISTNB]]|0.408|
|[[:human genes:n:nup153|NUP153]]|0.408|
|[[:human genes:c:c2orf27a|C2orf27A]]|0.408|
|[[:human genes:n:nol8|NOL8]]|0.406|
|[[:human genes:f:fbxw9|FBXW9]]|0.406|
|[[:human genes:c:cmya5|CMYA5]]|0.405|
|[[:human genes:n:npipb5|NPIPB5]]|0.405|
|[[:human genes:n:npipb8|NPIPB8]]|0.405|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.404|
|[[:human genes:r:rfc1|RFC1]]|0.404|
|[[:human genes:h:hcls1|HCLS1]]|0.404|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.403|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.403|
|[[:human genes:z:znf655|ZNF655]]|0.403|
|[[:human genes:z:znf541|ZNF541]]|0.402|
|[[:human genes:c:cbwd6|CBWD6]]|0.402|
|[[:human genes:g:golga8o|GOLGA8O]]|0.402|
|[[:human genes:p:psmc5|PSMC5]]|0.402|
|[[:human genes:a:akirin2|AKIRIN2]]|0.401|
|[[:human genes:t:ticrr|TICRR]]|0.401|
|[[:human genes:s:ssh2|SSH2]]|0.401|
|[[:human genes:n:naaladl1|NAALADL1]]|0.4|
|[[:human genes:r:rplp1|RPLP1]]|0.4|
|[[:human genes:c:cactin|CACTIN]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|3/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1321
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XYLT2 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>