YBX3 [The Human Chemical-Genetic Interaction Map Project]

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======= YBX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YBX3
  * **<color #00a2e8>Official Name</color>**: Y-box binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8531|8531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16989|P16989]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YBX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YBX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603437|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CSD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|polysome binding|
|regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|regulation of cellular response to osmotic stress|
|positive regulation of cytoplasmic translation|
|cellular hyperosmotic response|
|negative regulation of necroptotic process|
|negative regulation of skeletal muscle tissue development|
|regulation of response to osmotic stress|
|negative regulation of programmed necrotic cell death|
|negative regulation of necrotic cell death|
|regulation of necroptotic process|
|3-UTR-mediated mRNA stabilization|
|regulation of programmed necrotic cell death|
|hyperosmotic response|
|regulation of necrotic cell death|
|regulation of cytoplasmic translation|
|Rho GTPase binding|
|cellular response to osmotic stress|
|mRNA stabilization|
|positive regulation of organ growth|
|RNA stabilization|
|negative regulation of striated muscle tissue development|
|response to cold|
|regulation of skeletal muscle tissue development|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|mRNA 3-UTR binding|
|response to osmotic stress|
|negative regulation of mRNA metabolic process|
|regulation of organ growth|
|negative regulation of intrinsic apoptotic signaling pathway|
|double-stranded DNA binding|
|bicellular tight junction|
|positive regulation of translation|
|regulation of striated muscle tissue development|
|male gonad development|
|regulation of muscle tissue development|
|development of primary male sexual characteristics|
|regulation of muscle organ development|
|positive regulation of cellular amide metabolic process|
|male sex differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|fertilization|
|positive regulation of developmental growth|
|response to temperature stimulus|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|gonad development|
|development of primary sexual characteristics|
|negative regulation of apoptotic signaling pathway|
|cellular response to tumor necrosis factor|
|transcription corepressor activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|response to tumor necrosis factor|
|sex differentiation|
|negative regulation of catabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of mRNA metabolic process|
|regulation of developmental growth|
|regulation of translation|
|in utero embryonic development|
|regulation of apoptotic signaling pathway|
|regulation of cellular amide metabolic process|
|reproductive structure development|
|reproductive system development|
|negative regulation of intracellular signal transduction|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|regulation of growth|
|DNA-binding transcription factor activity|
|gamete generation|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of developmental process|
|embryo development|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|response to cytokine|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of intracellular signal transduction|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.32|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.21|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.7|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.71|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.73|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9672
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YBX3 Expression in NALM6 Cells: 7.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>