YKT6 [The Human Chemical-Genetic Interaction Map Project]

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======= YKT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YKT6
  * **<color #00a2e8>Official Name</color>**: YKT6 v-SNARE homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10652|10652]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15498|O15498]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YKT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YKT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606209|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. {ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:9211930}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synaptobrevin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|basal dendrite|
|apical dendrite|
|protein-cysteine S-palmitoyltransferase activity|
|SNAP receptor activity|
|vesicle docking involved in exocytosis|
|SNARE complex|
|vesicle docking|
|exocytic process|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle targeting|
|transport vesicle|
|retrograde transport, endosome to Golgi|
|membrane fusion|
|cytoplasmic vesicle membrane|
|cytosolic transport|
|organelle localization by membrane tethering|
|establishment of vesicle localization|
|membrane docking|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|endosomal transport|
|endosome|
|cadherin binding|
|establishment of organelle localization|
|neuronal cell body|
|Golgi vesicle transport|
|organelle localization|
|Golgi membrane|
|exocytosis|
|membrane organization|
|Golgi apparatus|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|secretion|
|mitochondrion|
|integral component of plasma membrane|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.13|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.93|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.82|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.78|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.447|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 709/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|24/26|
|breast|33/33|
|central nervous system|48/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1624
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YKT6 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>