YLPM1 [The Human Chemical-Genetic Interaction Map Project]

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======= YLPM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YLPM1
  * **<color #00a2e8>Official Name</color>**: YLP motif containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56252|56252]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49750|P49750]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YLPM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YLPM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of telomere maintenance|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|nuclear speck|
|regulation of organelle organization|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.84|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.77|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.72|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.34|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.31|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.16|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.97|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.95|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.87|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.82|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.71|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.72|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.78|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.84|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.86|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.87|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.9|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.04|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.07|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.16|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.23|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.24|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.37|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.39|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.53|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.55|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.57|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.71|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.73|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.75|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.79|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.07|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.13|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.17|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.26|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.29|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.34|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|3.45|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.49|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.67|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.68|
|[[:results:exp211|AICAR 240μM R05 exp211]]|5.03|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|5.53|
|[[:results:exp116|AICAR 240μM R03 exp116]]|6.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ak2|AK2]]|0.421|
|[[:human genes:c:cnbp|CNBP]]|0.415|
|[[:human genes:t:tfdp1|TFDP1]]|0.414|
|[[:human genes:i:ikzf2|IKZF2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6695
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YLPM1 Expression in NALM6 Cells: 7.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>