YTHDF1 [The Human Chemical-Genetic Interaction Map Project]

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======= YTHDF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YTHDF1
  * **<color #00a2e8>Official Name</color>**: YTH N6-methyladenosine RNA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54915|54915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYJ9|Q9BYJ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YTHDF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YTHDF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616529|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A- containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). {ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|YTH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N6-methyladenosine-containing RNA binding|
|regulation of antigen processing and presentation|
|positive regulation of translational initiation|
|regulation of axon guidance|
|regulation of long-term synaptic potentiation|
|ribosome binding|
|regulation of translational initiation|
|memory|
|positive regulation of translation|
|learning|
|positive regulation of cellular amide metabolic process|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|regulation of chemotaxis|
|learning or memory|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of translation|
|regulation of cellular amide metabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|posttranscriptional regulation of gene expression|
|behavior|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|nervous system process|
|RNA binding|
|generation of neurons|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|regulation of cell differentiation|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp302|35°C R06 exp302]]|-2|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.99|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.99|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.98|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.74|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.27|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.39|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.443|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YTHDF1 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>