YWHAG [The Human Chemical-Genetic Interaction Map Project]

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======= YWHAG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YWHAG
  * **<color #00a2e8>Official Name</color>**: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7532|7532]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61981|P61981]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YWHAG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YWHAG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605356|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. {ECO:0000269|PubMed:16511572}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|14-3-3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase C inhibitor activity|
|insulin-like growth factor receptor binding|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|protein kinase C binding|
|receptor tyrosine kinase binding|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|presynapse|
|ciliary basal body-plasma membrane docking|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|G2/M transition of mitotic cell cycle|
|negative regulation of protein serine/threonine kinase activity|
|cell cycle G2/M phase transition|
|cellular response to insulin stimulus|
|organelle localization by membrane tethering|
|positive regulation of apoptotic signaling pathway|
|membrane docking|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|regulation of synaptic plasticity|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|mitochondrial transport|
|negative regulation of protein kinase activity|
|response to insulin|
|protein domain specific binding|
|negative regulation of kinase activity|
|cellular response to peptide hormone stimulus|
|mitotic cell cycle phase transition|
|negative regulation of transferase activity|
|cell cycle phase transition|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|cilium assembly|
|protein targeting|
|cilium organization|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|focal adhesion|
|mitochondrion organization|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|response to peptide|
|regulation of protein serine/threonine kinase activity|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|organelle assembly|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|membrane organization|
|regulation of kinase activity|
|response to hormone|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|regulation of transferase activity|
|positive regulation of transport|
|intracellular protein transport|
|cell cycle process|
|response to organonitrogen compound|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.8|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.73|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.85|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.24|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YWHAG Expression in NALM6 Cells: 8.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>