YWHAZ [The Human Chemical-Genetic Interaction Map Project]

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======= YWHAZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YWHAZ
  * **<color #00a2e8>Official Name</color>**: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7534|7534]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63104|P63104]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YWHAZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YWHAZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601288|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|14-3-3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptic target recognition|
|Golgi reassembly|
|establishment of Golgi localization|
|organelle inheritance|
|Golgi inheritance|
|regulation of synapse maturation|
|Golgi localization|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|hippocampal mossy fiber to CA3 synapse|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|neuron recognition|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|melanosome|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|ion channel binding|
|mitochondrial membrane organization|
|Golgi organization|
|platelet activation|
|vesicle|
|blood microparticle|
|positive regulation of apoptotic signaling pathway|
|regulation of mRNA stability|
|regulation of mitochondrion organization|
|regulation of RNA stability|
|regulation of protein localization to membrane|
|regulation of mRNA catabolic process|
|mitochondrial transport|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cell recognition|
|protein domain specific binding|
|ubiquitin protein ligase binding|
|blood coagulation|
|coagulation|
|hemostasis|
|cadherin binding|
|positive regulation of cellular protein localization|
|regulation of mRNA metabolic process|
|transcription factor binding|
|glutamatergic synapse|
|protein targeting|
|establishment of organelle localization|
|regulation of apoptotic signaling pathway|
|focal adhesion|
|endomembrane system organization|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|wound healing|
|regulation of body fluid levels|
|posttranscriptional regulation of gene expression|
|regulation of cellular protein localization|
|response to wounding|
|organelle localization|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|neuron development|
|regulation of cellular catabolic process|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|regulation of nervous system development|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of protein localization|
|identical protein binding|
|cell activation|
|response to cytokine|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|RNA binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YWHAZ Expression in NALM6 Cells: 8.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>