ZBTB7B [The Human Chemical-Genetic Interaction Map Project]

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======= ZBTB7B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB7B
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 7B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51043|51043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15156|O15156]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB7B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB7B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607646|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9370309}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of NK T cell proliferation|
|positive regulation of SREBP signaling pathway|
|NK T cell differentiation|
|negative regulation of CD8-positive, alpha-beta T cell differentiation|
|negative regulation of NK T cell activation|
|interleukin-17 secretion|
|regulation of SREBP signaling pathway|
|interleukin-17 production|
|regulation of NK T cell proliferation|
|regulation of CD8-positive, alpha-beta T cell differentiation|
|negative regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of T-helper 17 cell differentiation|
|regulation of NK T cell activation|
|negative regulation of T-helper 17 type immune response|
|negative regulation of alpha-beta T cell proliferation|
|positive regulation of brown fat cell differentiation|
|regulation of CD8-positive, alpha-beta T cell activation|
|regulation of brown fat cell differentiation|
|negative regulation of T-helper cell differentiation|
|regulation of transcription involved in cell fate commitment|
|regulation of T-helper 17 cell differentiation|
|positive regulation of histone deacetylation|
|adaptive thermogenesis|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|ectoderm development|
|regulation of T-helper 17 type immune response|
|positive regulation of insulin receptor signaling pathway|
|positive regulation of protein deacetylation|
|positive regulation of cellular response to insulin stimulus|
|enhancer sequence-specific DNA binding|
|negative regulation of alpha-beta T cell differentiation|
|regulation of histone deacetylation|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell proliferation|
|regulation of T-helper cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of alpha-beta T cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of T cell differentiation|
|regulation of protein deacetylation|
|negative regulation of adaptive immune response|
|lactation|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|cytokine secretion|
|alpha-beta T cell differentiation|
|negative regulation of lymphocyte differentiation|
|negative regulation of T cell proliferation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|alpha-beta T cell activation|
|positive regulation of fat cell differentiation|
|regulation of alpha-beta T cell differentiation|
|regulation of insulin receptor signaling pathway|
|regulation of cellular response to insulin stimulus|
|body fluid secretion|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|positive regulation of T cell differentiation|
|positive regulation of histone modification|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of cold-induced thermogenesis|
|negative regulation of leukocyte differentiation|
|positive regulation of chromatin organization|
|negative regulation of T cell activation|
|histone deacetylase binding|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of fat cell differentiation|
|mammary gland development|
|T cell differentiation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of cold-induced thermogenesis|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of histone modification|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|cytokine production|
|regulation of T cell proliferation|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of adaptive immune response|
|protein localization to extracellular region|
|regulation of lymphocyte differentiation|
|peptide secretion|
|positive regulation of chromosome organization|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|positive regulation of hemopoiesis|
|regulation of chromatin organization|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|response to insulin|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|leukocyte differentiation|
|regulation of chromosome organization|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|response to peptide hormone|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|gland development|
|positive regulation of cell activation|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|regulation of immune effector process|
|response to peptide|
|transcription by RNA polymerase II|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|regulation of cell activation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|response to hormone|
|leukocyte activation|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cell activation|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.73|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.521|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB7B Expression in NALM6 Cells: 2.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>