ZC3H13 [The Human Chemical-Genetic Interaction Map Project]

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======= ZC3H13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZC3H13
  * **<color #00a2e8>Official Name</color>**: zinc finger CCCH-type containing 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23091|23091]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T200|Q5T200]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZC3H13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZC3H13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616453|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the WTAP complex that is involved in RNA processing and cell cycle (PubMed:24100041). {ECO:0000269|PubMed:24100041}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA N6-methyladenosine methyltransferase complex|
|mRNA methylation|
|mRNA modification|
|regulation of stem cell population maintenance|
|RNA methylation|
|RNA modification|
|macromolecule methylation|
|methylation|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.5|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.35|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.11|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.01|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.01|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.94|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.85|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.82|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.82|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.81|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.78|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.77|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.71|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.7|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.81|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.94|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.06|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.21|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.32|
|[[:results:exp132|Metformin 40μM R03 exp132]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.475|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2593
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZC3H13 Expression in NALM6 Cells: 7.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>