ZC3H14 [The Human Chemical-Genetic Interaction Map Project]

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======= ZC3H14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZC3H14
  * **<color #00a2e8>Official Name</color>**: zinc finger CCCH-type containing 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79882|79882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PJT7|Q6PJT7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZC3H14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZC3H14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613279|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mRNA polyadenylation|
|negative regulation of mRNA 3-end processing|
|regulation of mRNA polyadenylation|
|poly(A) binding|
|regulation of mRNA 3-end processing|
|negative regulation of mRNA processing|
|dendrite cytoplasm|
|axon cytoplasm|
|negative regulation of mRNA metabolic process|
|regulation of mRNA processing|
|ribonucleoprotein complex|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|regulation of mRNA metabolic process|
|nuclear speck|
|posttranscriptional regulation of gene expression|
|regulation of cellular catabolic process|
|nucleolus|
|regulation of catabolic process|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-3.46|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.86|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.41|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.06|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.03|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.01|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.99|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.88|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.84|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.79|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.71|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.73|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.76|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.83|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.85|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.86|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.27|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZC3H14 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>