ZC3H15 [The Human Chemical-Genetic Interaction Map Project]

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======= ZC3H15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZC3H15
  * **<color #00a2e8>Official Name</color>**: zinc finger CCCH-type containing 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55854|55854]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WU90|Q8WU90]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZC3H15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZC3H15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619704|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protects DRG1 from proteolytic degradation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic translation|
|cadherin binding|
|translation|
|peptide biosynthetic process|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|amide biosynthetic process|
|peptide metabolic process|
|cytokine-mediated signaling pathway|
|positive regulation of hydrolase activity|
|cellular amide metabolic process|
|nucleolus|
|cellular response to cytokine stimulus|
|response to cytokine|
|regulation of hydrolase activity|
|RNA binding|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.73|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.72|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.74|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.75|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.78|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.8|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.8|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.81|
|[[:results:exp453|B02 10μM R08 exp453]]|1.83|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.87|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.88|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.9|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.9|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.91|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.93|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.94|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.95|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.99|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.04|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.09|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.33|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.68|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:drg1|DRG1]]|0.487|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12072
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZC3H15 Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>