ZC3H7A [The Human Chemical-Genetic Interaction Map Project]

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======= ZC3H7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZC3H7A
  * **<color #00a2e8>Official Name</color>**: zinc finger CCCH-type containing 7A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29066|29066]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWR0|Q8IWR0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZC3H7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZC3H7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619819|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|production of miRNAs involved in gene silencing by miRNA|
|miRNA binding|
|production of small RNA involved in gene silencing by RNA|
|dsRNA processing|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|gene silencing by RNA|
|gene silencing|
|regulation of gene expression, epigenetic|
|posttranscriptional regulation of gene expression|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|negative regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.08|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.76|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.73|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.78|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.87|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.88|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.97|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.03|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.04|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.18|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.28|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.49|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.53|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.07|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|4.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZC3H7A Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>