ZC3H8 [The Human Chemical-Genetic Interaction Map Project]

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======= ZC3H8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZC3H8
  * **<color #00a2e8>Official Name</color>**: zinc finger CCCH-type containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84524|84524]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5P1|Q8N5P1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZC3H8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZC3H8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621273|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269|PubMed:12077251, ECO:0000269|PubMed:12153508, ECO:0000269|PubMed:23932780}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone locus body|
|positive regulation of thymocyte apoptotic process|
|snRNA transcription by RNA polymerase III|
|negative regulation of T cell differentiation in thymus|
|positive regulation of transcription by RNA polymerase III|
|regulation of thymocyte apoptotic process|
|positive regulation of T cell apoptotic process|
|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|
|positive regulation of lymphocyte apoptotic process|
|regulation of transcription by RNA polymerase III|
|transcriptionally active chromatin|
|regulation of T cell differentiation in thymus|
|transcription elongation factor complex|
|positive regulation of leukocyte apoptotic process|
|T cell homeostasis|
|regulation of T cell apoptotic process|
|transcription by RNA polymerase III|
|negative regulation of T cell differentiation|
|regulation of lymphocyte apoptotic process|
|Cajal body|
|lymphocyte homeostasis|
|negative regulation of lymphocyte differentiation|
|leukocyte homeostasis|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|regulation of leukocyte apoptotic process|
|ncRNA transcription|
|negative regulation of leukocyte differentiation|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|homeostasis of number of cells|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|nuclear body|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|regulation of T cell activation|
|regulation of cell-cell adhesion|
|sequence-specific DNA binding|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|negative regulation of transcription by RNA polymerase II|
|apoptotic process|
|negative regulation of developmental process|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 167/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|11/28|
|bone|5/26|
|breast|6/33|
|central nervous system|15/56|
|cervix|3/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|3/20|
|lung|22/75|
|lymphocyte|4/16|
|ovary|7/26|
|pancreas|3/24|
|peripheral nervous system|9/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|11/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2059
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZC3H8 Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>