ZDHHC17 [The Human Chemical-Genetic Interaction Map Project]

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======= ZDHHC17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZDHHC17
  * **<color #00a2e8>Official Name</color>**: zinc finger DHHC-type palmitoyltransferase 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23390|23390]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IUH5|Q8IUH5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZDHHC17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZDHHC17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607799|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Palmitoylates MPP1 in erythrocytes (PubMed:22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299). {ECO:0000269|PubMed:12393793, ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740, ECO:0000269|PubMed:18794299, ECO:0000269|PubMed:19139280, ECO:0000269|PubMed:22496366, ECO:0000269|PubMed:28757145}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|zf-DHHC|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipoprotein localization|
|lipoprotein transport|
|magnesium ion transmembrane transport|
|magnesium ion transmembrane transporter activity|
|magnesium ion transport|
|palmitoyltransferase activity|
|Golgi-associated vesicle membrane|
|protein-cysteine S-palmitoyltransferase activity|
|protein palmitoylation|
|aggresome|
|presynaptic membrane|
|protein lipidation|
|lipoprotein biosynthetic process|
|lipoprotein metabolic process|
|cytoplasmic vesicle membrane|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|protein acylation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|divalent metal ion transport|
|divalent inorganic cation transport|
|cell junction|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|Golgi membrane|
|metal ion transport|
|inorganic ion transmembrane transport|
|intracellular membrane-bounded organelle|
|cation transport|
|ion transmembrane transport|
|Golgi apparatus|
|positive regulation of intracellular signal transduction|
|identical protein binding|
|transmembrane transport|
|ion transport|
|organonitrogen compound biosynthetic process|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|positive regulation of signal transduction|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.82|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.75|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.75|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.79|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.83|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.83|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.89|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.92|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.01|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.04|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.11|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.17|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.23|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.42|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.42|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.65|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nf1|NF1]]|0.505|
|[[:human genes:s:spred2|SPRED2]]|0.437|
|[[:human genes:d:dusp6|DUSP6]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13930
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZDHHC17 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>