ZFC3H1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZFC3H1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFC3H1
  * **<color #00a2e8>Official Name</color>**: zinc finger C3H1-type containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196441|196441]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60293|O60293]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFC3H1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFC3H1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620956|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. {ECO:0000269|PubMed:27871484}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3H1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exosome (RNase complex)|
|nucleolus|
|RNA processing|
|RNA binding|
|extracellular space|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.83|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.11|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.05|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.71|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.71|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.72|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.76|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.77|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.79|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.83|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.85|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.89|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.93|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.96|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.99|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.01|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.08|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.09|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.11|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.15|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.16|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.2|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.2|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.26|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.27|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.34|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.41|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.53|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.7|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.72|
|[[:results:exp504|MK2206 4μM R08 exp504]]|3.2|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rbm7|RBM7]]|0.537|
|[[:human genes:r:rbm26|RBM26]]|0.491|
|[[:human genes:z:zcchc8|ZCCHC8]]|0.466|
|[[:human genes:c:c9orf78|C9orf78]]|0.461|
|[[:human genes:e:eif4a1|EIF4A1]]|0.456|
|[[:human genes:p:pmaip1|PMAIP1]]|0.45|
|[[:human genes:w:wbp11|WBP11]]|0.424|
|[[:human genes:p:pqbp1|PQBP1]]|0.418|
|[[:human genes:p:pcif1|PCIF1]]|0.415|
|[[:human genes:s:sap130|SAP130]]|0.409|
|[[:human genes:u:ube2q1|UBE2Q1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 44/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|4/28|
|bone|5/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|1/20|
|lung|4/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3689
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFC3H1 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>