ZFP36 [The Human Chemical-Genetic Interaction Map Project]

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======= ZFP36 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFP36
  * **<color #00a2e8>Official Name</color>**: ZFP36 ring finger protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7538|7538]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26651|P26651]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFP36&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFP36|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia- inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE- mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post- transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:10751406, ECO:0000269|PubMed:11279239, ECO:0000269|PubMed:11719186, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:12748283, ECO:0000269|PubMed:15187101, ECO:0000269|PubMed:15634918, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15766526, ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16702957, ECO:0000269|PubMed:17030620, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:19188452, ECO:0000269|PubMed:20221403, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21775632, ECO:0000269|PubMed:23644599, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:26926077, ECO:0000269|PubMed:27182009, ECO:0000269|PubMed:27193233, ECO:0000269|PubMed:9703499}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Dcp1-Dcp2 complex|
|negative regulation of polynucleotide adenylyltransferase activity|
|positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|
|regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|
|regulation of polynucleotide adenylyltransferase activity|
|regulation of intracellular mRNA localization|
|positive regulation of intracellular mRNA localization|
|negative regulation of interleukin-2 biosynthetic process|
|regulation of keratinocyte apoptotic process|
|p38MAPK cascade|
|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|
|RISC-loading complex|
|negative regulation of erythrocyte differentiation|
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|response to granulocyte macrophage colony-stimulating factor|
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of translation, ncRNA-mediated|
|negative regulation of translation, ncRNA-mediated|
|miRNA mediated inhibition of translation|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|3-UTR-mediated mRNA destabilization|
|RNA polymerase binding|
|CCR4-NOT complex|
|exosome (RNase complex)|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of interleukin-2 biosynthetic process|
|3-UTR-mediated mRNA stabilization|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|nuclear-transcribed mRNA poly(A) tail shortening|
|positive regulation of gene silencing by miRNA|
|negative regulation of interleukin-2 production|
|positive regulation of posttranscriptional gene silencing|
|C-C chemokine binding|
|negative regulation of viral transcription|
|mRNA 3-UTR AU-rich region binding|
|14-3-3 protein binding|
|mRNA destabilization|
|negative regulation of cytokine biosynthetic process|
|RNA destabilization|
|regulation of keratinocyte proliferation|
|regulation of keratinocyte differentiation|
|cellular response to epidermal growth factor stimulus|
|mRNA stabilization|
|regulation of erythrocyte differentiation|
|response to epidermal growth factor|
|gene silencing by miRNA|
|positive regulation of mRNA catabolic process|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|regulation of interleukin-2 production|
|cellular response to glucocorticoid stimulus|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|heat shock protein binding|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|negative regulation of RNA catabolic process|
|cellular response to corticosteroid stimulus|
|positive regulation of fat cell differentiation|
|regulation of epidermal cell differentiation|
|regulation of viral transcription|
|cytoplasmic stress granule|
|mRNA 3-UTR binding|
|negative regulation of myeloid cell differentiation|
|positive regulation of mRNA metabolic process|
|regulation of epithelial cell apoptotic process|
|negative regulation of mRNA metabolic process|
|P-body|
|regulation of epidermis development|
|regulation of gene silencing by miRNA|
|gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|negative regulation of viral process|
|stress-activated MAPK cascade|
|regulation of cytokine biosynthetic process|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|regulation of fat cell differentiation|
|regulation of gene silencing|
|negative regulation of translation|
|negative regulation of hemopoiesis|
|regulation of epithelial cell differentiation|
|stress-activated protein kinase signaling cascade|
|response to glucocorticoid|
|negative regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor production|
|gene silencing|
|regulation of tumor necrosis factor superfamily cytokine production|
|ribonucleoprotein complex|
|mRNA transport|
|mRNA binding|
|response to corticosteroid|
|regulation of mRNA stability|
|cellular response to lipopolysaccharide|
|regulation of RNA stability|
|cellular response to steroid hormone stimulus|
|nucleic acid transport|
|cellular response to molecule of bacterial origin|
|RNA transport|
|response to starvation|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of viral process|
|cellular response to biotic stimulus|
|negative regulation of multi-organism process|
|mRNA catabolic process|
|RNA localization|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of myeloid cell differentiation|
|regulation of gene expression, epigenetic|
|nucleobase-containing compound transport|
|cellular response to tumor necrosis factor|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|response to tumor necrosis factor|
|negative regulation of cytokine production|
|negative regulation of transferase activity|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|regulation of epithelial cell proliferation|
|enzyme binding|
|regulation of translation|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|nucleobase-containing compound catabolic process|
|signal transduction by protein phosphorylation|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|regulation of hemopoiesis|
|protein kinase binding|
|organic cyclic compound catabolic process|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|response to growth factor|
|cellular response to organic cyclic compound|
|response to wounding|
|cellular response to hormone stimulus|
|response to bacterium|
|regulation of cytokine production|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.75|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.72|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.73|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.78|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFP36 Expression in NALM6 Cells: 3.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>