ZFP36L1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZFP36L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFP36L1
  * **<color #00a2e8>Official Name</color>**: ZFP36 ring finger protein like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=677|677]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07352|Q07352]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFP36L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFP36L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601064|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE- mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity- joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity). {ECO:0000250|UniProtKB:P17431, ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173, ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381, ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481, ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157, ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217, ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173, ECO:0000269|PubMed:27182009}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tis11B N|
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to raffinose|
|cellular response to raffinose|
|septum transversum development|
|regulation of intracellular mRNA localization|
|proepicardium development|
|positive regulation of intracellular mRNA localization|
|regulation of keratinocyte apoptotic process|
|chorio-allantoic fusion|
|p38MAPK cascade|
|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|
|cellular response to salt stress|
|negative regulation of erythrocyte differentiation|
|positive regulation of monocyte differentiation|
|mesendoderm development|
|spongiotrophoblast layer development|
|3-UTR-mediated mRNA destabilization|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of monocyte differentiation|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|labyrinthine layer morphogenesis|
|response to salt stress|
|mRNA 3-UTR AU-rich region binding|
|embryonic placenta morphogenesis|
|regulation of B cell differentiation|
|ERK1 and ERK2 cascade|
|regulation of mRNA 3-end processing|
|14-3-3 protein binding|
|mRNA destabilization|
|RNA destabilization|
|phosphatidylinositol 3-kinase signaling|
|regulation of keratinocyte proliferation|
|cellular response to osmotic stress|
|protein kinase B signaling|
|regulation of keratinocyte differentiation|
|cellular response to epidermal growth factor stimulus|
|labyrinthine layer development|
|regulation of erythrocyte differentiation|
|T cell differentiation in thymus|
|response to epidermal growth factor|
|positive regulation of mRNA catabolic process|
|regulation of myoblast differentiation|
|cellular response to cAMP|
|positive regulation of myeloid leukocyte differentiation|
|cellular response to glucocorticoid stimulus|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|cellular response to corticosteroid stimulus|
|positive regulation of fat cell differentiation|
|regulation of epidermal cell differentiation|
|regulation of stem cell proliferation|
|vasculogenesis|
|phosphatidylinositol-mediated signaling|
|endoderm development|
|inositol lipid-mediated signaling|
|negative regulation of myeloid cell differentiation|
|mRNA 3-UTR binding|
|response to osmotic stress|
|positive regulation of mRNA metabolic process|
|regulation of epithelial cell apoptotic process|
|cellular response to carbohydrate stimulus|
|multicellular organism growth|
|P-body|
|regulation of epidermis development|
|embryonic placenta development|
|positive regulation of myeloid cell differentiation|
|response to cAMP|
|stress-activated MAPK cascade|
|cellular response to fibroblast growth factor stimulus|
|regulation of myeloid leukocyte differentiation|
|response to fibroblast growth factor|
|regulation of fat cell differentiation|
|mesoderm development|
|negative regulation of translation|
|T cell differentiation|
|response to organophosphorus|
|negative regulation of hemopoiesis|
|regulation of mRNA processing|
|regulation of epithelial cell differentiation|
|stress-activated protein kinase signaling cascade|
|response to glucocorticoid|
|positive regulation of leukocyte differentiation|
|negative regulation of cellular amide metabolic process|
|placenta development|
|response to purine-containing compound|
|ribonucleoprotein complex|
|mRNA transport|
|cellular response to transforming growth factor beta stimulus|
|neural tube development|
|mRNA binding|
|response to corticosteroid|
|response to transforming growth factor beta|
|cellular response to insulin stimulus|
|regulation of lymphocyte differentiation|
|response to carbohydrate|
|regulation of mRNA stability|
|regulation of RNA stability|
|cellular response to hypoxia|
|positive regulation of hemopoiesis|
|cellular response to steroid hormone stimulus|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|cellular response to decreased oxygen levels|
|regulation of mRNA catabolic process|
|regulation of B cell activation|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|mRNA catabolic process|
|RNA localization|
|mesenchyme development|
|regulation of myeloid cell differentiation|
|response to insulin|
|negative regulation of cell cycle phase transition|
|T cell activation|
|lymphocyte differentiation|
|cellular response to tumor necrosis factor|
|nucleobase-containing compound transport|
|RNA catabolic process|
|response to tumor necrosis factor|
|cellular response to peptide hormone stimulus|
|regulation of leukocyte differentiation|
|negative regulation of mitotic cell cycle|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|negative regulation of cell cycle process|
|cellular response to peptide|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|leukocyte differentiation|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|regulation of translation|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|nucleobase-containing compound catabolic process|
|in utero embryonic development|
|response to oxygen levels|
|lymphocyte activation|
|developmental growth|
|response to peptide hormone|
|growth|
|signal transduction by protein phosphorylation|
|regulation of cellular amide metabolic process|
|blood vessel morphogenesis|
|regulation of mitotic cell cycle phase transition|
|reproductive structure development|
|reproductive system development|
|positive regulation of catabolic process|
|embryonic organ development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|response to peptide|
|mRNA processing|
|organic cyclic compound catabolic process|
|blood vessel development|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|heart development|
|response to growth factor|
|cellular response to organic cyclic compound|
|cell population proliferation|
|hemopoiesis|
|embryonic morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|regulation of cell activation|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|regulation of cell cycle process|
|regulation of cellular catabolic process|
|tube development|
|response to lipid|
|circulatory system development|
|RNA processing|
|cellular macromolecule catabolic process|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|phosphorylation|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2|
|[[:results:exp302|35°C R06 exp302]]|-1.85|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.85|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.79|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.9|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfp36l2|ZFP36L2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFP36L1 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>