ZFP91 [The Human Chemical-Genetic Interaction Map Project]

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======= ZFP91 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFP91
  * **<color #00a2e8>Official Name</color>**: ZFP91 zinc finger protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80829|80829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JP5|Q96JP5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFP91&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFP91|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619289|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. {ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of NF-kappaB-inducing kinase activity|
|protein K63-linked ubiquitination|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|regulation of NIK/NF-kappaB signaling|
|nucleic acid binding|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|activation of protein kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|protein ubiquitination|
|protein modification by small protein conjugation|
|regulation of protein kinase activity|
|nucleolus|
|regulation of kinase activity|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.24|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.07|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.99|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.98|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.91|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.9|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.73|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.71|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.79|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.84|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.19|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:crls1|CRLS1]]|0.441|
|[[:human genes:t:triap1|TRIAP1]]|0.431|
|[[:human genes:p:pmm2|PMM2]]|0.418|
|[[:human genes:t:taz|TAZ]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3608
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFP91 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>