ZFPM1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZFPM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZFPM1
  * **<color #00a2e8>Official Name</color>**: zinc finger protein, FOG family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=161882|161882]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IX07|Q8IX07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZFPM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZFPM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601950|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mast cell differentiation|
|negative regulation of interleukin-4 biosynthetic process|
|regulation of mast cell differentiation|
|definitive erythrocyte differentiation|
|primitive erythrocyte differentiation|
|tricuspid valve formation|
|mitral valve formation|
|regulation of interleukin-4 biosynthetic process|
|transcriptional activation by promoter-enhancer looping|
|regulation of definitive erythrocyte differentiation|
|dsDNA loop formation|
|gene looping|
|tricuspid valve morphogenesis|
|negative regulation of interleukin-4 production|
|primitive hemopoiesis|
|tricuspid valve development|
|atrioventricular valve formation|
|mitral valve morphogenesis|
|T-helper cell lineage commitment|
|CD4-positive, alpha-beta T cell lineage commitment|
|mitral valve development|
|positive regulation of interferon-gamma biosynthetic process|
|alpha-beta T cell lineage commitment|
|heart valve formation|
|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|
|atrial septum morphogenesis|
|regulation of interferon-gamma biosynthetic process|
|definitive hemopoiesis|
|megakaryocyte development|
|granulocyte differentiation|
|platelet formation|
|platelet morphogenesis|
|embryonic hemopoiesis|
|T cell lineage commitment|
|megakaryocyte differentiation|
|atrial septum development|
|atrioventricular valve morphogenesis|
|bone cell development|
|positive T cell selection|
|atrioventricular valve development|
|regulation of interleukin-4 production|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T-helper cell differentiation|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|cardiac atrium morphogenesis|
|negative regulation of cytokine biosynthetic process|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|cardiac atrium development|
|CD4-positive, alpha-beta T cell activation|
|T cell selection|
|ventricular septum morphogenesis|
|negative regulation of fat cell differentiation|
|regulation of erythrocyte differentiation|
|negative regulation of myeloid leukocyte differentiation|
|alpha-beta T cell differentiation|
|heart valve morphogenesis|
|RNA polymerase II activating transcription factor binding|
|regulation of megakaryocyte differentiation|
|transcriptional repressor complex|
|myeloid cell development|
|heart valve development|
|alpha-beta T cell activation|
|RNA polymerase II transcription factor binding|
|positive regulation of interferon-gamma production|
|T cell activation involved in immune response|
|positive regulation of cytokine biosynthetic process|
|cardiac muscle tissue morphogenesis|
|ventricular septum development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|negative regulation of myeloid cell differentiation|
|regulation of chemokine production|
|muscle tissue morphogenesis|
|erythrocyte differentiation|
|muscle organ morphogenesis|
|erythrocyte homeostasis|
|regulation of interferon-gamma production|
|negative regulation of leukocyte differentiation|
|negative regulation of protein binding|
|regulation of cytokine biosynthetic process|
|myeloid cell homeostasis|
|cardiac septum development|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|regulation of fat cell differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|T cell differentiation|
|negative regulation of hemopoiesis|
|cardiac muscle tissue development|
|cardiac chamber development|
|negative regulation of binding|
|homeostasis of number of cells|
|bone development|
|transcription factor complex|
|regulation of protein binding|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|T cell activation|
|lymphocyte differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|heart morphogenesis|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|striated muscle tissue development|
|blood coagulation|
|coagulation|
|muscle organ development|
|muscle tissue development|
|hemostasis|
|leukocyte differentiation|
|transcription factor binding|
|regulation of binding|
|lymphocyte activation|
|embryonic organ development|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|muscle structure development|
|wound healing|
|skeletal system development|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|heart development|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|response to wounding|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|regulation of cytokine production|
|chromatin organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|cellular component morphogenesis|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|chromosome organization|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14959
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZFPM1 Expression in NALM6 Cells: 3.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>