ZMIZ1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZMIZ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZMIZ1
  * **<color #00a2e8>Official Name</color>**: zinc finger MIZ-type containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57178|57178]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULJ6|Q9ULJ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZMIZ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZMIZ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607159|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as transcriptional coactivator. Increases ligand- dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). {ECO:0000250|UniProtKB:Q6P1E1, ECO:0000269|PubMed:14609956, ECO:0000269|PubMed:26522984}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-MIZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitellogenesis|
|SUMO ligase activity|
|cytoplasm organization|
|chromatin-mediated maintenance of transcription|
|positive regulation of fibroblast proliferation|
|positive regulation of Notch signaling pathway|
|artery morphogenesis|
|RNA polymerase II transcription factor binding|
|positive regulation of gene expression, epigenetic|
|cell aging|
|nuclear receptor transcription coactivator activity|
|protein sumoylation|
|vasculogenesis|
|chromatin organization involved in regulation of transcription|
|regulation of fibroblast proliferation|
|transcription coregulator activity|
|positive regulation of T cell differentiation|
|artery development|
|positive regulation of lymphocyte differentiation|
|regulation of Notch signaling pathway|
|female gamete generation|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte differentiation|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of gene expression, epigenetic|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|aging|
|regulation of leukocyte cell-cell adhesion|
|peptidyl-lysine modification|
|regulation of T cell activation|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of lymphocyte activation|
|in utero embryonic development|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|nuclear speck|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|regulation of hemopoiesis|
|blood vessel development|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|heart development|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|gamete generation|
|chromatin organization|
|protein modification by small protein conjugation|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|chromosome organization|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.17|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.88|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.77|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:brpf1|BRPF1]]|0.46|
|[[:human genes:t:tada2b|TADA2B]]|0.445|
|[[:human genes:s:ssbp2|SSBP2]]|0.438|
|[[:human genes:i:id3|ID3]]|0.435|
|[[:human genes:l:ldb1|LDB1]]|0.431|
|[[:human genes:k:kat2a|KAT2A]]|0.43|
|[[:human genes:t:trim33|TRIM33]]|0.412|
|[[:human genes:t:taf5l|TAF5L]]|0.408|
|[[:human genes:g:gltscr1|GLTSCR1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1857
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZMIZ1 Expression in NALM6 Cells: 7.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>