ZNF236 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF236 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF236
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 236
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7776|7776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL36|Q9UL36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF236&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF236|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|DNA-binding transcription factor activity|
|cellular chemical homeostasis|
|cellular homeostasis|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|DNA binding|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.77|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.74|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.75|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.76|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.78|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps3|RPS3]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2225
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF236 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>