ZNF367 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF367 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF367
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 367
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=195828|195828]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTV3|Q7RTV3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF367&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF367|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes. {ECO:0000269|PubMed:15344908}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA-binding transcription factor activity|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.8|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.7|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.44|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.4|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.39|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.82|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.79|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.73|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.74|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.8|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.88|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.95|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.99|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.41|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7432
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF367 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>