ZNF385A [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF385A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF385A
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 385A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25946|25946]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PM9|Q96PM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF385A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF385A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609124|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti- proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269|PubMed:17719541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2 jaz|
|zf-met|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet alpha granule organization|
|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|mRNA localization resulting in posttranscriptional regulation of gene expression|
|regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|intracellular mRNA localization|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|megakaryocyte development|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|platelet formation|
|platelet morphogenesis|
|megakaryocyte differentiation|
|positive regulation of signal transduction by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|bone cell development|
|regulation of cytoplasmic translation|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|secretory granule organization|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|myeloid cell development|
|positive regulation of fat cell differentiation|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|p53 binding|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|mRNA 3-UTR binding|
|DNA damage response, signal transduction by p53 class mediator|
|negative regulation of response to DNA damage stimulus|
|positive regulation of cell cycle arrest|
|mitotic DNA damage checkpoint|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of response to DNA damage stimulus|
|negative regulation of G1/S transition of mitotic cell cycle|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|regulation of fat cell differentiation|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cell cycle G1/S phase transition|
|regulation of signal transduction by p53 class mediator|
|cell cycle checkpoint|
|locomotory behavior|
|bone development|
|negative regulation of mitotic cell cycle phase transition|
|RNA localization|
|regulation of response to DNA damage stimulus|
|myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|negative regulation of cell cycle phase transition|
|nuclear chromatin|
|learning or memory|
|positive regulation of cell cycle process|
|hemostasis|
|cognition|
|vesicle organization|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of translation|
|neuronal cell body|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|regulation of cellular amide metabolic process|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|dendrite|
|regulation of cell cycle phase transition|
|skeletal system development|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|posttranscriptional regulation of gene expression|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|behavior|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|immune system development|
|mitotic cell cycle|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cellular component morphogenesis|
|zinc ion binding|
|nucleolus|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|apoptotic process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|RNA binding|
|DNA binding|
|regulation of response to stress|
|regulation of apoptotic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.532|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8700
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF385A Expression in NALM6 Cells: 2.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>