ZNF541 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF541 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF541
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 541
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84215|84215]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0D2|Q9H0D2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF541&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF541|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619942|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis. {ECO:0000250|UniProtKB:Q0GGX2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ELM2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase complex|
|transcription factor complex|
|transcription regulatory region DNA binding|
|transcription factor binding|
|spermatogenesis|
|male gamete generation|
|DNA-binding transcription factor activity|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc6a17|SLC6A17]]|0.484|
|[[:human genes:p:polr2j3|POLR2J3]]|0.483|
|[[:human genes:d:ddtl|DDTL]]|0.483|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.482|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.468|
|[[:human genes:c:chd4|CHD4]]|0.465|
|[[:human genes:a:ankle1|ANKLE1]]|0.463|
|[[:human genes:c:copa|COPA]]|0.454|
|[[:human genes:t:twistnb|TWISTNB]]|0.453|
|[[:human genes:i:igfn1|IGFN1]]|0.449|
|[[:human genes:d:disp2|DISP2]]|0.449|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.448|
|[[:human genes:c:cdh24|CDH24]]|0.446|
|[[:human genes:f:fam25b|FAM25B]]|0.445|
|[[:human genes:p:psma6|PSMA6]]|0.441|
|[[:human genes:p:prim1|PRIM1]]|0.439|
|[[:human genes:r:rps2|RPS2]]|0.438|
|[[:human genes:p:polr2a|POLR2A]]|0.436|
|[[:human genes:a:ankle2|ANKLE2]]|0.435|
|[[:human genes:m:mbtd1|MBTD1]]|0.434|
|[[:human genes:d:dock6|DOCK6]]|0.433|
|[[:human genes:g:gprin2|GPRIN2]]|0.432|
|[[:human genes:o:orc6|ORC6]]|0.431|
|[[:human genes:f:fam160a1|FAM160A1]]|0.43|
|[[:human genes:c:copg1|COPG1]]|0.429|
|[[:human genes:a:arcn1|ARCN1]]|0.429|
|[[:human genes:h:hap1|HAP1]]|0.427|
|[[:human genes:s:slc4a1|SLC4A1]]|0.426|
|[[:human genes:p:psmb4|PSMB4]]|0.425|
|[[:human genes:c:ccna2|CCNA2]]|0.424|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.423|
|[[:human genes:c:ccdc116|CCDC116]]|0.423|
|[[:human genes:c:cbwd3|CBWD3]]|0.421|
|[[:human genes:c:cgb2|CGB2]]|0.421|
|[[:human genes:k:kctd17|KCTD17]]|0.421|
|[[:human genes:c:cbwd5|CBWD5]]|0.42|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.42|
|[[:human genes:c:cbwd6|CBWD6]]|0.42|
|[[:human genes:r:rrp15|RRP15]]|0.419|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:r:rpl35|RPL35]]|0.419|
|[[:human genes:r:ranbp2|RANBP2]]|0.416|
|[[:human genes:s:snip1|SNIP1]]|0.413|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.411|
|[[:human genes:d:ddt|DDT]]|0.411|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.411|
|[[:human genes:n:nupl1|NUPL1]]|0.411|
|[[:human genes:p:pole|POLE]]|0.411|
|[[:human genes:a:aqr|AQR]]|0.408|
|[[:human genes:p:pcf11|PCF11]]|0.407|
|[[:human genes:m:med14|MED14]]|0.406|
|[[:human genes:t:tnpo3|TNPO3]]|0.405|
|[[:human genes:l:loc643669|LOC643669]]|0.403|
|[[:human genes:c:cgb1|CGB1]]|0.403|
|[[:human genes:c:cln6|CLN6]]|0.402|
|[[:human genes:o:osbp|OSBP]]|0.402|
|[[:human genes:x:xylt2|XYLT2]]|0.402|
|[[:human genes:n:npipb5|NPIPB5]]|0.402|
|[[:human genes:u:utp3|UTP3]]|0.401|
|[[:human genes:e:exosc5|EXOSC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2163
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF541 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>