ZNF574 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF574 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF574
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 574
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64763|64763]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZN55|Q6ZN55]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF574&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF574|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|1.71|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.75|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.77|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.82|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.83|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.86|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.88|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2.15|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.49|
|[[:human genes:r:rpl35|RPL35]]|0.485|
|[[:human genes:c:c14orf93|C14orf93]]|0.471|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.46|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.459|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.458|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.458|
|[[:human genes:d:dtl|DTL]]|0.454|
|[[:human genes:t:ticrr|TICRR]]|0.452|
|[[:human genes:e:exosc9|EXOSC9]]|0.45|
|[[:human genes:d:ddx56|DDX56]]|0.443|
|[[:human genes:n:nol12|NOL12]]|0.442|
|[[:human genes:t:tceb3c|TCEB3C]]|0.439|
|[[:human genes:c:chaf1a|CHAF1A]]|0.438|
|[[:human genes:r:rpl6|RPL6]]|0.436|
|[[:human genes:a:acsf2|ACSF2]]|0.435|
|[[:human genes:c:ccdc116|CCDC116]]|0.434|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.433|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.432|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.429|
|[[:human genes:r:rps12|RPS12]]|0.425|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.424|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.423|
|[[:human genes:p:pole|POLE]]|0.423|
|[[:human genes:s:snrpa1|SNRPA1]]|0.42|
|[[:human genes:p:psmb4|PSMB4]]|0.419|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.419|
|[[:human genes:c:copg1|COPG1]]|0.419|
|[[:human genes:c:chd4|CHD4]]|0.419|
|[[:human genes:s:supt5h|SUPT5H]]|0.418|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.415|
|[[:human genes:t:tfip11|TFIP11]]|0.414|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.414|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.414|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.413|
|[[:human genes:c:copb1|COPB1]]|0.412|
|[[:human genes:p:ppm1d|PPM1D]]|0.411|
|[[:human genes:n:narfl|NARFL]]|0.409|
|[[:human genes:c:cbwd5|CBWD5]]|0.409|
|[[:human genes:g:gprin2|GPRIN2]]|0.409|
|[[:human genes:o:orc1|ORC1]]|0.408|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.408|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.407|
|[[:human genes:r:rps5|RPS5]]|0.406|
|[[:human genes:m:mt1e|MT1E]]|0.406|
|[[:human genes:n:nfatc4|NFATC4]]|0.405|
|[[:human genes:a:aamp|AAMP]]|0.404|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.403|
|[[:human genes:c:cbwd3|CBWD3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 178/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|7/28|
|bone|1/26|
|breast|5/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|8/21|
|liver|6/20|
|lung|15/75|
|lymphocyte|4/16|
|ovary|7/26|
|pancreas|6/24|
|peripheral nervous system|4/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 303
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF574 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>