ZNF675 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF675 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF675
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 675
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=171392|171392]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TD23|Q8TD23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF675&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF675|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KRAB|
|zf-C2H2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-1-mediated signaling pathway|
|regulation of interleukin-1-mediated signaling pathway|
|negative regulation of JUN kinase activity|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of transcription regulatory region DNA binding|
|bone resorption|
|negative regulation of osteoclast differentiation|
|negative regulation of JNK cascade|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of myeloid leukocyte differentiation|
|bone remodeling|
|regulation of transcription regulatory region DNA binding|
|negative regulation of DNA binding|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|regulation of osteoclast differentiation|
|I-kappaB kinase/NF-kappaB signaling|
|negative regulation of MAP kinase activity|
|negative regulation of myeloid cell differentiation|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of JUN kinase activity|
|negative regulation of leukocyte differentiation|
|tissue remodeling|
|regulation of myeloid leukocyte differentiation|
|regulation of DNA binding|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of hemopoiesis|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of MAPK cascade|
|negative regulation of binding|
|regulation of response to cytokine stimulus|
|regulation of JNK cascade|
|tissue homeostasis|
|negative regulation of protein kinase activity|
|regulation of myeloid cell differentiation|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|regulation of leukocyte differentiation|
|negative regulation of transferase activity|
|ubiquitin protein ligase binding|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|regulation of binding|
|negative regulation of protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cytokine-mediated signaling pathway|
|perinuclear region of cytoplasm|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|negative regulation of developmental process|
|regulation of transferase activity|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.03|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.79|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.85|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.87|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.04|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.04|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.15|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.28|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrn3|RRN3]]|0.426|
|[[:human genes:c:chmp2a|CHMP2A]]|0.417|
|[[:human genes:s:slc6a17|SLC6A17]]|0.411|
|[[:human genes:c:ccna2|CCNA2]]|0.408|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.405|
|[[:human genes:r:rrp15|RRP15]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF675 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>