ZSWIM8 [The Human Chemical-Genetic Interaction Map Project]

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======= ZSWIM8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZSWIM8
  * **<color #00a2e8>Official Name</color>**: zinc finger SWIM-type containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23053|23053]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A7E2V4|A7E2V4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZSWIM8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZSWIM8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619213|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Cul2-RING ubiquitin ligase complex|
|regulation of axon guidance|
|regulation of axonogenesis|
|regulation of chemotaxis|
|regulation of cell morphogenesis involved in differentiation|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of nervous system development|
|regulation of cell development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|generation of neurons|
|neurogenesis|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.09|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.08|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.98|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.97|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.8|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.79|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.85|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.93|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.96|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.98|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.17|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtf2h1|GTF2H1]]|0.484|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3843
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZSWIM8 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>