Nifuroxazide 5μM R03 exp102 [The Human Chemical-Genetic Interaction Map Project]

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====== Nifuroxazide 5μM R03 exp102 ======
==== Mechanism of Action ====
Nitrofuran antibiotic
  * **<color #00a2e8>Class / Subclass 1:</color>** Infectious Disease / Antibiotic




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Nifuroxazide%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 965-52-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5337997|5337997]]
    * **<color #00a2e8>IUPAC:</color>** %%4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
    * **<color #00a2e8>INCHI Key:</color>** YCWSUKQGVSGXJO-NTUHNPAUSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 275.22
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1C(=O)NN=CC2=CC=C(O2)[N+](=O)[O-])O
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC(=CC=C1C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-])O
    * **<color #00a2e8>Molecular Formula:</color>** C12H9N3O5
{{:chemogenomics:structures:chem-0031.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** 481984
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C12H9N3O5 276.0615; found 276.0611
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** NAZ
    * **<color #00a2e8>Min:</color>** -7.3989; **<color #00a2e8>Max:</color>** 98.6617
{{:chemogenomics:dose_response:dr_99.png?nolink&500 |}}
\\ 
\\ 
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |3.0271    |
| IC30  |5.0046    |
| IC40  |7.5570    |
| IC50  |11.0306    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 5µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.3
    * **<color #00a2e8>Numbers of reads</color>**: 16229465


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|14/49|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Nifuroxazide_5uM_Round-3_exp102.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Nifuroxazide 5μM R03 exp102'>
{{:chemogenomics:cranks_plots:exp102.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ALKBH5|ALKBH5]]|-4.06|<0.01|
|[[:human_genes:T:TCAIM|TCAIM]]|-3.54|<0.01|
|[[:human_genes:P:PRDX1|PRDX1]]|-3.53|<0.01|
|[[:human_genes:M:MDH2|MDH2]]|-3.49|<0.01|
|[[:human_genes:L:LUC7L2|LUC7L2]]|-3.23|<0.01|
|[[:human_genes:P:PAG1|PAG1]]|-3.12|<0.01|
|[[:human_genes:L:LIAS|LIAS]]|-3.00|<0.01|
|[[:human_genes:C:CSK|CSK]]|-2.99|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-2.92|0.02|
|[[:human_genes:C:CNOT8|CNOT8]]|-2.78|<0.01|
|[[:human_genes:D:DLST|DLST]]|-2.77|0.04|
|[[:human_genes:S:SELO|SELO]]|-2.69|0.03|
|[[:human_genes:C:C7orf55-LUC7L2|C7orf55-LUC7L2]]|-2.66|0.03|
|[[:human_genes:C:C16orf72|C16orf72]]|-2.49|0.09|
|[[:human_genes:M:MYBPC3|MYBPC3]]|-2.43|0.08|
|[[:human_genes:A:AUH|AUH]]|-2.41|0.05|
|[[:human_genes:P:PLEKHA2|PLEKHA2]]|-2.39|0.12|
|[[:human_genes:P:PC|PC]]|-2.36|0.06|
|[[:human_genes:W:WBSCR16|WBSCR16]]|-2.35|0.20|
|[[:human_genes:M:MECR|MECR]]|-2.31|0.07|
|[[:human_genes:M:MTF2|MTF2]]|-2.30|0.10|
|[[:human_genes:N:NUDT5|NUDT5]]|-2.30|0.10|
|[[:human_genes:F:FIBP|FIBP]]|-2.27|0.08|
|[[:human_genes:P:PBRM1|PBRM1]]|-2.26|0.08|
|[[:human_genes:P:PNP|PNP]]|-2.24|0.09|
|[[:human_genes:G:GLRX5|GLRX5]]|-2.24|0.18|
|[[:human_genes:N:NGLY1|NGLY1]]|-2.24|0.09|
|[[:human_genes:A:ATP2B1|ATP2B1]]|-2.24|0.18|
|[[:human_genes:A:ABCG2|ABCG2]]|-2.23|0.09|
|[[:human_genes:P:PCDHA10|PCDHA10]]|-2.20|0.09|
|[[:human_genes:E:ERGIC1|ERGIC1]]|2.70|<0.01|
|[[:human_genes:Z:ZZZ3|ZZZ3]]|2.70|<0.01|
|[[:human_genes:Z:ZFY|ZFY]]|2.73|<0.01|
|[[:human_genes:A:AKT2|AKT2]]|2.77|<0.01|
|[[:human_genes:S:SUPT6H|SUPT6H]]|2.83|0.03|
|[[:human_genes:R:RAB10|RAB10]]|2.90|<0.01|
|[[:human_genes:P:PIK3CD|PIK3CD]]|3.07|<0.01|
|[[:human_genes:P:PDP1|PDP1]]|3.10|<0.01|
|[[:human_genes:S:SLC25A33|SLC25A33]]|3.14|<0.01|
|[[:human_genes:I:IGLL1|IGLL1]]|3.18|<0.01|
|[[:human_genes:S:SYK|SYK]]|3.26|<0.01|
|[[:human_genes:C:CREBBP|CREBBP]]|3.27|<0.01|
|[[:human_genes:A:ACSL4|ACSL4]]|3.30|<0.01|
|[[:human_genes:S:SLC25A5|SLC25A5]]|3.49|<0.01|
|[[:human_genes:G:GOT1|GOT1]]|3.50|<0.01|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|3.51|<0.01|
|[[:human_genes:C:CD79B|CD79B]]|3.61|<0.01|
|[[:human_genes:F:FDPS|FDPS]]|3.64|<0.01|
|[[:human_genes:C:CD79A|CD79A]]|3.74|<0.01|
|[[:human_genes:D:DDX3X|DDX3X]]|3.82|<0.01|
|[[:human_genes:P:PDHX|PDHX]]|4.13|<0.01|
|[[:human_genes:B:BEND3|BEND3]]|4.31|<0.01|
|[[:human_genes:P:PRPS1|PRPS1]]|4.82|<0.01|
|[[:human_genes:M:MPC2|MPC2]]|5.15|<0.01|
|[[:human_genes:D:DLAT|DLAT]]|5.15|<0.01|
|[[:human_genes:M:MPC1|MPC1]]|6.29|<0.01|
|[[:human_genes:C:CS|CS]]|6.30|<0.01|
|[[:human_genes:M:MDH1|MDH1]]|7.02|<0.01|
|[[:human_genes:P:PDHB|PDHB]]|7.55|<0.01|
|[[:human_genes:P:PDHA1|PDHA1]]|8.39|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|0.087|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.084|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|0.08|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.074|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.064|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|0.06|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|0.057|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.054|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|0.052|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.105|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp274|Citral 50μM R06 exp274]]|0.097|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.077|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.072|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.056|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|0.056|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.056|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.053|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp275|Citral 75μM R06 exp275]]|0.053|<button type="primary" size="small" modal="18">View</button>|
</modal>


<modal id="1" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  THZ531 0.225μM R08 exp444">
{{:chemogenomics:comparison_plots:exp102_vs_exp444.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp102_vs_exp535.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  THZ531 0.11 to 0.175μM on day4 R07 exp413">
{{:chemogenomics:comparison_plots:exp102_vs_exp413.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp102_vs_exp525.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp102_vs_exp526.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412">
{{:chemogenomics:comparison_plots:exp102_vs_exp412.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp102_vs_exp248.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  Rotenone 0.07μM R08 exp431">
{{:chemogenomics:comparison_plots:exp102_vs_exp431.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  THZ531 0.11 to 0.125μM on day4 R07 exp410">
{{:chemogenomics:comparison_plots:exp102_vs_exp410.png?nolink |}}
</modal>

<modal id="10" size="lg" title="MLN-4924 0.2μM R00 exp21  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp21.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Citral 50μM R06 exp274  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp274.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Ethanol 0.01 R05 exp234  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp234.png?nolink |}}
</modal>

<modal id="13" size="lg" title="MS023 2μM R03 exp134  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp134.png?nolink |}}
</modal>

<modal id="14" size="lg" title="ML-792 0.2μM R08 exp505  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp505.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Mubritinib 0.2μM R01 exp48  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp48.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp488.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp489.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Citral 75μM R06 exp275  vs  Nifuroxazide 5μM R03 exp102">
{{:chemogenomics:comparison_plots:exp102_vs_exp275.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|pyruvate dehydrogenase (NAD+) activity|442.11|PDHA1,PDHB,DLAT,PDHX|
|B cell receptor complex|414.48|CD79A,CD79B,SYK|
|acetyl-CoA biosynthetic process from pyruvate|368.42|PDHB,DLAT,MPC2,PDHX|
|pyruvate dehydrogenase activity|331.58|PDHA1,DLAT,PDHX|
|pyruvate dehydrogenase [NAD(P)+] activity|331.58|PDHA1,PDHB,PDHX|
|immunoglobulin complex|221.05|CD79A,CD79B,SYK,IGLL1|
|acetyl-CoA biosynthetic process|212.55|PDHA1,PDHB,DLAT,MPC2,PDHX|
|acetyl-CoA metabolic process|98.68|PDHA1,PDHB,DLAT,MPC2,PDHX|
|thioester biosynthetic process|82.90|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|acyl-CoA biosynthetic process|82.90|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|ribonucleoside bisphosphate biosynthetic process|65.02|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|purine nucleoside bisphosphate biosynthetic process|65.02|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|nucleoside bisphosphate biosynthetic process|65.02|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|acyl-CoA metabolic process|38.11|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|thioester metabolic process|38.11|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|ribonucleoside bisphosphate metabolic process|28.83|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|purine nucleoside bisphosphate metabolic process|28.83|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|nucleoside bisphosphate metabolic process|28.83|PDHA1,PDHB,DLAT,MPC2,PDHX,ACSL4|
|ribose phosphate biosynthetic process|19.64|PDHA1,PDHB,DLAT,MPC2,PRPS1,PDHX,ACSL4|
</modal>