Golgicide-A 2μM R03 exp121 [The Human Chemical-Genetic Interaction Map Project]

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====== Golgicide-A 2μM R03 exp121 ======
==== Mechanism of Action ====
Inhibits cis-Golgi ArfGEF, blocks secretion at ER-Golgi
  * **<color #00a2e8>Class / Subclass 1:</color>** Organelle Function / Vesicule Trafficking Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1005036-73-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/3154410|3154410]]
    * **<color #00a2e8>IUPAC:</color>** %%6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2
    * **<color #00a2e8>INCHI Key:</color>** NJZHEQOUHLZCOX-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 284.3
    * **<color #00a2e8>Canonical SMILES:</color>** C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C17H14F2N2
{{:chemogenomics:structures:chem-0075.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** G0923
    * **<color #00a2e8>Lot #:</color>** 105M4619V
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C17H14F2N2 285.11978; found 285.11995
</panel>


<panel title='Dose Response Curve'>
Dose response curve not available.
</panel>


</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 2µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.9
    * **<color #00a2e8>Numbers of reads</color>**: 13633891


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Golgicide_A_2uM_Round-3_exp121.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Golgicide-A 2μM R03 exp121'>
{{:chemogenomics:cranks_plots:exp121.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ARF1|ARF1]]|-3.70|<0.01|
|[[:human_genes:K:KDSR|KDSR]]|-2.47|0.21|
|[[:human_genes:F:FOXG1|FOXG1]]|-2.38|0.55|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.31|0.71|
|[[:human_genes:C:CLDN9|CLDN9]]|-2.27|0.47|
|[[:human_genes:T:TBC1D20|TBC1D20]]|-2.22|0.47|
|[[:human_genes:C:COG7|COG7]]|-2.19|0.47|
|[[:human_genes:T:TDP1|TDP1]]|-2.11|0.55|
|[[:human_genes:D:DBH|DBH]]|-2.08|0.71|
|[[:human_genes:R:RAD1|RAD1]]|-2.07|0.58|
|[[:human_genes:C:C20orf195|C20orf195]]|-2.03|0.65|
|[[:human_genes:V:VPS25|VPS25]]|-2.02|0.71|
|[[:human_genes:L:LRRC63|LRRC63]]|-2.01|0.88|
|[[:human_genes:Z:ZMAT2|ZMAT2]]|-1.95|0.71|
|[[:human_genes:M:MSR1|MSR1]]|-1.95|0.71|
|[[:human_genes:G:GOLGA8H|GOLGA8H]]|-1.94|0.72|
|[[:human_genes:W:WSB1|WSB1]]|-1.94|0.71|
|[[:human_genes:C:CHEK2|CHEK2]]|-1.94|0.71|
|[[:human_genes:Z:ZNF311|ZNF311]]|-1.93|0.71|
|[[:human_genes:P:PABPC1L|PABPC1L]]|-1.91|0.71|
|[[:human_genes:R:RPL18|RPL18]]|-1.90|0.89|
|[[:human_genes:N:NPHS2|NPHS2]]|-1.89|0.71|
|[[:human_genes:S:SNAPIN|SNAPIN]]|-1.88|0.71|
|[[:human_genes:N:NTF4|NTF4]]|-1.88|0.71|
|[[:human_genes:G:GJA8|GJA8]]|-1.87|0.71|
|[[:human_genes:O:OSGEP|OSGEP]]|-1.86|0.71|
|[[:human_genes:L:LPCAT1|LPCAT1]]|-1.86|0.71|
|[[:human_genes:P:POT1|POT1]]|-1.86|0.71|
|[[:human_genes:U:URGCP|URGCP]]|-1.84|0.71|
|[[:human_genes:T:TNFRSF10D|TNFRSF10D]]|-1.84|0.71|
|[[:human_genes:S:SCGB1D1|SCGB1D1]]|1.86|0.81|
|[[:human_genes:L:LACC1|LACC1]]|1.87|0.81|
|[[:human_genes:C:CFAP45|CFAP45]]|1.87|0.87|
|[[:human_genes:T:TMC2|TMC2]]|1.90|0.81|
|[[:human_genes:D:DUSP2|DUSP2]]|1.90|0.81|
|[[:human_genes:K:KLRB1|KLRB1]]|1.92|0.81|
|[[:human_genes:A:ANKRD32|ANKRD32]]|1.93|0.81|
|[[:human_genes:R:RBBP8NL|RBBP8NL]]|1.94|0.81|
|[[:human_genes:H:HOXB7|HOXB7]]|1.95|0.81|
|[[:human_genes:T:TBC1D3I|TBC1D3I]]|1.97|0.85|
|[[:human_genes:T:TBC1D3E|TBC1D3E]]|1.97|0.85|
|[[:human_genes:T:TBC1D3K|TBC1D3K]]|1.98|0.85|
|[[:human_genes:T:TBC1D3L|TBC1D3L]]|1.98|0.85|
|[[:human_genes:P:PSG8|PSG8]]|1.98|0.81|
|[[:human_genes:T:TSPY2|TSPY2]]|1.98|0.81|
|[[:human_genes:H:HSPB11|HSPB11]]|1.99|0.81|
|[[:human_genes:R:RIPK2|RIPK2]]|2.03|0.68|
|[[:human_genes:H:HOXB9|HOXB9]]|2.04|0.68|
|[[:human_genes:F:FADS2|FADS2]]|2.08|0.81|
|[[:human_genes:S:SART1|SART1]]|2.08|0.88|
|[[:human_genes:C:CCT4|CCT4]]|2.11|0.81|
|[[:human_genes:H:HUS1B|HUS1B]]|2.16|0.68|
|[[:human_genes:A:ADH6|ADH6]]|2.17|0.68|
|[[:human_genes:R:RND3|RND3]]|2.26|0.68|
|[[:human_genes:Z:ZNF320|ZNF320]]|2.32|0.68|
|[[:human_genes:R:RPL8|RPL8]]|2.45|0.81|
|[[:human_genes:C:CLSPN|CLSPN]]|2.51|0.68|
|[[:human_genes:E:EIF5B|EIF5B]]|2.60|0.85|
|[[:human_genes:N:NUP88|NUP88]]|2.69|0.68|
|[[:human_genes:P:PRPF18|PRPF18]]|2.73|0.68|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp392|PT-1 25μM R07 exp392]]|0.056|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|0.051|<button type="primary" size="small" modal="2">View</button>|
</modal>


<modal id="1" size="lg" title="Golgicide-A 2μM R03 exp121  vs  PT-1 25μM R07 exp392">
{{:chemogenomics:comparison_plots:exp121_vs_exp392.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Golgicide-A 2μM R03 exp121  vs  PFI-3 10μM R03 exp144">
{{:chemogenomics:comparison_plots:exp121_vs_exp144.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>