MS094 2μM R03 exp136 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== MS094 2μM R03 exp136 ======
==== Mechanism of Action ====
Inactive control for MS023 PRMT1 inhibitor
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1831110-55-4
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 288.2
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C17H24N2O2
{{:chemogenomics:structures:chem-0087.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Structural Genomics Consortium
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C17H24N2O2 289.19105; found 289.19184
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** MS094
    * **<color #00a2e8>Min:</color>** -7.1739; **<color #00a2e8>Max:</color>** 27.9782
{{:chemogenomics:dose_response:dr_95.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 2µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 8.1
    * **<color #00a2e8>Numbers of reads</color>**: 9689785


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/MS094_2uM_Round-3_exp136.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='MS094 2μM R03 exp136'>
{{:chemogenomics:cranks_plots:exp136.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PYROXD1|PYROXD1]]|-2.95|0.74|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.52|0.69|
|[[:human_genes:B:BHMT2|BHMT2]]|-2.34|0.69|
|[[:human_genes:C:C7orf55-LUC7L2|C7orf55-LUC7L2]]|-2.33|0.69|
|[[:human_genes:U:UBXN1|UBXN1]]|-2.28|0.69|
|[[:human_genes:C:C8orf82|C8orf82]]|-2.28|0.69|
|[[:human_genes:P:PRAMEF25|PRAMEF25]]|-2.20|0.86|
|[[:human_genes:S:SLC16A13|SLC16A13]]|-2.19|0.69|
|[[:human_genes:P:PRAMEF26|PRAMEF26]]|-2.18|0.86|
|[[:human_genes:R:RPL18|RPL18]]|-2.11|0.86|
|[[:human_genes:S:SRP72|SRP72]]|-2.08|0.74|
|[[:human_genes:S:SH2D3C|SH2D3C]]|-2.08|0.69|
|[[:human_genes:A:ATP6V1G1|ATP6V1G1]]|-2.08|0.74|
|[[:human_genes:N:NEIL1|NEIL1]]|-2.02|0.74|
|[[:human_genes:R:RCE1|RCE1]]|-2.01|0.74|
|[[:human_genes:P:PMM2|PMM2]]|-1.99|0.74|
|[[:human_genes:E:EPN3|EPN3]]|-1.98|0.74|
|[[:human_genes:K:KCNC3|KCNC3]]|-1.98|0.74|
|[[:human_genes:P:PRDM12|PRDM12]]|-1.95|0.74|
|[[:human_genes:S:SYT8|SYT8]]|-1.94|0.86|
|[[:human_genes:V:VEZT|VEZT]]|-1.93|0.80|
|[[:human_genes:C:C7orf76|C7orf76]]|-1.92|0.74|
|[[:human_genes:S:SRP68|SRP68]]|-1.90|0.74|
|[[:human_genes:C:CCDC30|CCDC30]]|-1.89|0.86|
|[[:human_genes:M:MT3|MT3]]|-1.87|0.74|
|[[:human_genes:N:NOTCH3|NOTCH3]]|-1.87|0.86|
|[[:human_genes:N:NLGN3|NLGN3]]|-1.86|0.74|
|[[:human_genes:K:KCNN1|KCNN1]]|-1.85|0.86|
|[[:human_genes:P:PPP1R12C|PPP1R12C]]|-1.84|0.79|
|[[:human_genes:D:DRD3|DRD3]]|-1.84|0.86|
|[[:human_genes:M:MINA|MINA]]|1.89|0.68|
|[[:human_genes:E:ERBB2IP|ERBB2IP]]|1.89|0.58|
|[[:human_genes:T:TTLL6|TTLL6]]|1.90|0.58|
|[[:human_genes:Z:ZNF681|ZNF681]]|1.92|0.73|
|[[:human_genes:T:TRAIP|TRAIP]]|1.92|0.72|
|[[:human_genes:E:ERVMER34-1|ERVMER34-1]]|1.93|0.58|
|[[:human_genes:H:HMGB3|HMGB3]]|1.94|0.58|
|[[:human_genes:P:PSMA1|PSMA1]]|1.95|0.68|
|[[:human_genes:P:PRPH2|PRPH2]]|1.99|0.54|
|[[:human_genes:T:TCHP|TCHP]]|1.99|0.68|
|[[:human_genes:S:SCN5A|SCN5A]]|2.01|0.52|
|[[:human_genes:E:EIF5|EIF5]]|2.03|0.68|
|[[:human_genes:S:SMC2|SMC2]]|2.04|0.68|
|[[:human_genes:A:AK9|AK9]]|2.06|0.43|
|[[:human_genes:P:PSMC2|PSMC2]]|2.06|0.68|
|[[:human_genes:K:KLHL41|KLHL41]]|2.09|0.39|
|[[:human_genes:W:WFDC9|WFDC9]]|2.09|0.39|
|[[:human_genes:R:RAB3GAP1|RAB3GAP1]]|2.11|0.39|
|[[:human_genes:T:TRRAP|TRRAP]]|2.12|0.68|
|[[:human_genes:R:RPS28|RPS28]]|2.13|0.72|
|[[:human_genes:A:ARMC1|ARMC1]]|2.17|0.39|
|[[:human_genes:C:CSNK1A1|CSNK1A1]]|2.22|0.39|
|[[:human_genes:S:SMC1A|SMC1A]]|2.26|0.72|
|[[:human_genes:S:SMR3A|SMR3A]]|2.30|0.39|
|[[:human_genes:Z:ZNF671|ZNF671]]|2.32|0.28|
|[[:human_genes:G:GPSM3|GPSM3]]|2.37|0.39|
|[[:human_genes:A:ARL6|ARL6]]|2.38|0.28|
|[[:human_genes:C:CFAP45|CFAP45]]|2.44|0.68|
|[[:human_genes:P:PFN2|PFN2]]|2.48|0.28|
|[[:human_genes:G:GNA11|GNA11]]|2.69|0.13|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>