OICR-9429 10μM R03 exp142 [The Human Chemical-Genetic Interaction Map Project]

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====== OICR-9429 10μM R03 exp142 ======
==== Mechanism of Action ====
Inhibits interaction between WDR5 and MLL1 (KMT2A) in MLL H3K4 trimethylase complex
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1801787-56-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/91623360|91623360]]
    * **<color #00a2e8>IUPAC:</color>** %%N-[2-(4-methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
    * **<color #00a2e8>INCHI Key:</color>** DJOVLOYCGXNVPI-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 555.6
    * **<color #00a2e8>Canonical SMILES:</color>** CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC=CC(=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C29H32F3N5O3
{{:chemogenomics:structures:chem-0093.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Structural Genomics Consortium
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C29H32F3N5O3 556.253; found 556.25499
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** OICR9429
    * **<color #00a2e8>Min:</color>** -4.8409; **<color #00a2e8>Max:</color>** 11.8137
{{:chemogenomics:dose_response:dr_104.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.6
    * **<color #00a2e8>Numbers of reads</color>**: 10688227


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/OICR-9429_10uM_Round-3_exp142.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='OICR-9429 10μM R03 exp142'>
{{:chemogenomics:cranks_plots:exp142.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SLC7A6|SLC7A6]]|-3.31|<0.01|
|[[:human_genes:R:RABIF|RABIF]]|-2.64|0.08|
|[[:human_genes:K:KBTBD7|KBTBD7]]|-2.56|0.09|
|[[:human_genes:E:EPAS1|EPAS1]]|-2.39|0.62|
|[[:human_genes:D:DNAJC13|DNAJC13]]|-2.17|0.52|
|[[:human_genes:L:LGI1|LGI1]]|-2.17|0.52|
|[[:human_genes:L:LEMD2|LEMD2]]|-2.16|0.63|
|[[:human_genes:E:EEFSEC|EEFSEC]]|-2.13|0.63|
|[[:human_genes:C:C7orf55-LUC7L2|C7orf55-LUC7L2]]|-2.06|0.69|
|[[:human_genes:D:DDX39A|DDX39A]]|-2.06|0.63|
|[[:human_genes:S:SASH3|SASH3]]|-2.02|0.63|
|[[:human_genes:P:PABPC1L|PABPC1L]]|-2.01|0.70|
|[[:human_genes:O:OR6C1|OR6C1]]|-2.00|0.69|
|[[:human_genes:C:CTDNEP1|CTDNEP1]]|-2.00|0.63|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.00|0.79|
|[[:human_genes:C:CCNB3|CCNB3]]|-1.97|0.68|
|[[:human_genes:C:COX10|COX10]]|-1.96|0.70|
|[[:human_genes:P:PNKP|PNKP]]|-1.93|0.70|
|[[:human_genes:L:LGALS12|LGALS12]]|-1.92|0.69|
|[[:human_genes:A:AP3B1|AP3B1]]|-1.92|0.69|
|[[:human_genes:T:THOC6|THOC6]]|-1.92|0.70|
|[[:human_genes:P:PROK2|PROK2]]|-1.91|0.70|
|[[:human_genes:B:BTN3A1|BTN3A1]]|-1.90|0.69|
|[[:human_genes:M:MS4A13|MS4A13]]|-1.89|0.84|
|[[:human_genes:P:PELO|PELO]]|-1.89|0.71|
|[[:human_genes:M:MOB2|MOB2]]|-1.89|0.69|
|[[:human_genes:P:PABPC4|PABPC4]]|-1.88|0.69|
|[[:human_genes:U:UHRF1|UHRF1]]|-1.88|0.70|
|[[:human_genes:O:OR7A5|OR7A5]]|-1.87|0.70|
|[[:human_genes:S:SNCB|SNCB]]|-1.87|0.70|
|[[:human_genes:R:RRM2|RRM2]]|1.85|0.91|
|[[:human_genes:C:CLCN5|CLCN5]]|1.85|0.87|
|[[:human_genes:E:ENTPD6|ENTPD6]]|1.85|0.87|
|[[:human_genes:L:LIPG|LIPG]]|1.85|0.87|
|[[:human_genes:S:SMC2|SMC2]]|1.88|0.91|
|[[:human_genes:Z:ZBED6CL|ZBED6CL]]|1.90|0.87|
|[[:human_genes:H:HM13|HM13]]|1.92|0.87|
|[[:human_genes:T:THBS4|THBS4]]|1.93|0.87|
|[[:human_genes:O:OR8K3|OR8K3]]|1.95|0.87|
|[[:human_genes:C:CTTNBP2|CTTNBP2]]|1.95|0.87|
|[[:human_genes:P:PSMB7|PSMB7]]|1.96|0.87|
|[[:human_genes:C:C1orf174|C1orf174]]|1.97|0.87|
|[[:human_genes:S:SLC29A1|SLC29A1]]|2.00|0.87|
|[[:human_genes:R:RPS19|RPS19]]|2.02|0.89|
|[[:human_genes:R:RPL34|RPL34]]|2.02|0.89|
|[[:human_genes:R:RARS|RARS]]|2.04|0.91|
|[[:human_genes:R:RAD9A|RAD9A]]|2.04|0.89|
|[[:human_genes:S:SHFM1|SHFM1]]|2.05|0.89|
|[[:human_genes:P:PPFIBP2|PPFIBP2]]|2.07|0.87|
|[[:human_genes:P:PRICKLE1|PRICKLE1]]|2.10|0.82|
|[[:human_genes:P:PRPF19|PRPF19]]|2.11|0.87|
|[[:human_genes:T:TGM1|TGM1]]|2.16|0.72|
|[[:human_genes:T:TICAM2|TICAM2]]|2.20|0.72|
|[[:human_genes:C:C8orf89|C8orf89]]|2.20|0.87|
|[[:human_genes:S:SYVN1|SYVN1]]|2.21|0.87|
|[[:human_genes:P:PARP6|PARP6]]|2.21|0.72|
|[[:human_genes:M:MRTO4|MRTO4]]|2.21|0.87|
|[[:human_genes:R:RBX1|RBX1]]|2.44|0.87|
|[[:human_genes:E:ESPL1|ESPL1]]|2.63|0.87|
|[[:human_genes:A:ANKLE2|ANKLE2]]|2.66|0.72|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp132|Metformin 40μM R03 exp132]]|0.056|<button type="primary" size="small" modal="1">View</button>|
</modal>


<modal id="1" size="lg" title="Metformin 40μM R03 exp132  vs  OICR-9429 10μM R03 exp142">
{{:chemogenomics:comparison_plots:exp132_vs_exp142.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>