SB203580 25μM R03 exp149 [The Human Chemical-Genetic Interaction Map Project]

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====== SB203580 25μM R03 exp149 ======
==== Mechanism of Action ====
p38 MAP kinase inhibitor
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Kinase Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Proteostasis / Autophagy Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole%%
    * **<color #00a2e8>Synonyms:</color>** RWJ 64809
    * **<color #00a2e8>CAS #:</color>** 152121-47-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/176155|176155]]
    * **<color #00a2e8>IUPAC:</color>** %%4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
    * **<color #00a2e8>INCHI Key:</color>** CDMGBJANTYXAIV-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 377.4
    * **<color #00a2e8>Canonical SMILES:</color>** CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C21H16FN3OS
{{:chemogenomics:structures:chem-0100.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Selleck Chemicals
    * **<color #00a2e8>Catalog #:</color>** S1076
    * **<color #00a2e8>Lot #:</color>** 08
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>LCMS:</color>** Tr 1.10 min, m/z 378+ [M+H]+, 376- [M-H]-
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** SB203580
    * **<color #00a2e8>Min:</color>** -0.3115; **<color #00a2e8>Max:</color>** 90.3000
{{:chemogenomics:dose_response:dr_120.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |19.1742    |
| IC30  |22.4861    |
| IC40  |25.6234    |
| IC50  |28.8863    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 25µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.1
    * **<color #00a2e8>Numbers of reads</color>**: 11544089


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|6/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/SB203580_25uM_Round-3_exp149.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='SB203580 25μM R03 exp149'>
{{:chemogenomics:cranks_plots:exp149.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:K:KDSR|KDSR]]|-4.78|<0.01|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-4.21|<0.01|
|[[:human_genes:V:VPS25|VPS25]]|-3.77|0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.30|<0.01|
|[[:human_genes:P:PGGT1B|PGGT1B]]|-2.58|0.05|
|[[:human_genes:G:GPR107|GPR107]]|-2.56|0.05|
|[[:human_genes:G:GNAS|GNAS]]|-2.44|0.08|
|[[:human_genes:S:SPTSSA|SPTSSA]]|-2.41|0.08|
|[[:human_genes:S:SPTLC2|SPTLC2]]|-2.38|0.09|
|[[:human_genes:S:SLC7A5|SLC7A5]]|-2.29|0.13|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.22|0.18|
|[[:human_genes:A:AGGF1|AGGF1]]|-2.20|0.26|
|[[:human_genes:C:CHKA|CHKA]]|-2.18|0.20|
|[[:human_genes:G:GDF1|GDF1]]|-2.15|0.23|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.11|0.26|
|[[:human_genes:S:SLC52A2|SLC52A2]]|-2.10|0.26|
|[[:human_genes:K:KCNN1|KCNN1]]|-2.10|0.58|
|[[:human_genes:I:ITGA5|ITGA5]]|-2.07|0.26|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.07|0.26|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.06|0.77|
|[[:human_genes:P:PLAA|PLAA]]|-2.01|0.35|
|[[:human_genes:H:HIST1H2AK|HIST1H2AK]]|-1.96|0.43|
|[[:human_genes:G:GFM1|GFM1]]|-1.91|0.71|
|[[:human_genes:P:PCDHB10|PCDHB10]]|-1.90|0.63|
|[[:human_genes:A:ATP7B|ATP7B]]|-1.90|0.54|
|[[:human_genes:C:CDC14A|CDC14A]]|-1.90|0.54|
|[[:human_genes:N:NKX6-3|NKX6-3]]|-1.88|0.57|
|[[:human_genes:R:RAF1|RAF1]]|-1.87|0.58|
|[[:human_genes:P:PABPC1L|PABPC1L]]|-1.87|0.71|
|[[:human_genes:C:CADPS|CADPS]]|-1.87|0.71|
|[[:human_genes:R:RASL10A|RASL10A]]|1.96|0.57|
|[[:human_genes:S:SESTD1|SESTD1]]|1.97|0.54|
|[[:human_genes:N:NMI|NMI]]|1.98|0.57|
|[[:human_genes:G:GFI1|GFI1]]|1.99|0.54|
|[[:human_genes:O:OR2A14|OR2A14]]|2.01|0.54|
|[[:human_genes:N:NPIPB4|NPIPB4]]|2.04|0.54|
|[[:human_genes:W:WBSCR22|WBSCR22]]|2.04|0.74|
|[[:human_genes:P:PAPSS1|PAPSS1]]|2.04|0.54|
|[[:human_genes:M:MASTL|MASTL]]|2.10|0.69|
|[[:human_genes:L:LEMD3|LEMD3]]|2.12|0.61|
|[[:human_genes:P:PLEKHA2|PLEKHA2]]|2.17|0.54|
|[[:human_genes:G:GPR87|GPR87]]|2.18|0.54|
|[[:human_genes:A:ASH1L|ASH1L]]|2.18|0.54|
|[[:human_genes:R:RPL13A|RPL13A]]|2.19|0.60|
|[[:human_genes:E:EFR3A|EFR3A]]|2.20|0.54|
|[[:human_genes:P:PAF1|PAF1]]|2.23|0.57|
|[[:human_genes:R:RAB5C|RAB5C]]|2.25|0.54|
|[[:human_genes:F:FLJ45513|FLJ45513]]|2.25|0.54|
|[[:human_genes:P:PNN|PNN]]|2.28|0.57|
|[[:human_genes:C:CBLB|CBLB]]|2.29|0.54|
|[[:human_genes:S:SUPT6H|SUPT6H]]|2.35|0.54|
|[[:human_genes:E:EIF5B|EIF5B]]|2.37|0.76|
|[[:human_genes:N:NKTR|NKTR]]|2.38|0.54|
|[[:human_genes:D:DNM2|DNM2]]|2.45|0.74|
|[[:human_genes:Z:ZNF571|ZNF571]]|2.45|0.54|
|[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|2.45|0.74|
|[[:human_genes:N:NOP58|NOP58]]|2.46|0.54|
|[[:human_genes:N:NPIPB3|NPIPB3]]|2.48|0.65|
|[[:human_genes:Z:ZNF431|ZNF431]]|2.66|0.54|
|[[:human_genes:T:TEX10|TEX10]]|2.78|0.51|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp538|ZLN024 50μM R08 exp538]]|0.086|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.083|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|0.068|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|0.062|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.051|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.096|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.091|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp358|FK-506 5μM R07 exp358]]|0.084|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|0.083|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.078|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp114|A-196 10μM R03 exp114]]|0.071|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.07|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.069|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.068|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.064|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|0.063|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.063|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|0.06|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.057|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.055|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|0.054|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp495|IWR1 50μM R08 exp495]]|0.054|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp131|L-74142 5μM R03 exp131]]|0.054|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp148|SB202190 10μM R03 exp148]]|0.054|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.052|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.052|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|0.051|<button type="primary" size="small" modal="27">View</button>|
</modal>


<modal id="1" size="lg" title="SB203580 25μM R03 exp149  vs  ZLN024 50μM R08 exp538">
{{:chemogenomics:comparison_plots:exp149_vs_exp538.png?nolink |}}
</modal>

<modal id="2" size="lg" title="SB203580 25μM R03 exp149  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp149_vs_exp422.png?nolink |}}
</modal>

<modal id="3" size="lg" title="SB203580 25μM R03 exp149  vs  SGC2043 10μM R03 exp152">
{{:chemogenomics:comparison_plots:exp149_vs_exp152.png?nolink |}}
</modal>

<modal id="4" size="lg" title="SB203580 25μM R03 exp149  vs  Trametinib 10μM R02 exp83">
{{:chemogenomics:comparison_plots:exp149_vs_exp83.png?nolink |}}
</modal>

<modal id="5" size="lg" title="SB203580 25μM R03 exp149  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp149_vs_exp530.png?nolink |}}
</modal>

<modal id="6" size="lg" title="CCT251545 20μM R07 exp326  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp326.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp77.png?nolink |}}
</modal>

<modal id="8" size="lg" title="FK-506 5μM R07 exp358  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp358.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Lapatinib 5μM R01 exp47  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp47.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Bisphenol F 50μM R08 exp457  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp457.png?nolink |}}
</modal>

<modal id="11" size="lg" title="A-196 10μM R03 exp114  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp114_vs_exp149.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp164.png?nolink |}}
</modal>

<modal id="13" size="lg" title="NN-Dimethylsphingosine 2.5μM R08 exp508  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp508.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Cannabidiol 13μM R08 exp465  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp465.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp344.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Myriocin 25μM R06 exp293  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp293.png?nolink |}}
</modal>

<modal id="17" size="lg" title="BS-181 20μM R08 exp461  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp461.png?nolink |}}
</modal>

<modal id="18" size="lg" title="BRD2 inhibitor II 20μM R07 exp341  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp341.png?nolink |}}
</modal>

<modal id="19" size="lg" title="EPZ-5676 30μM R05 exp233  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp233.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BH1 1μM R04 exp169  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp169.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Momordin-Ic 10μM R08 exp506  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp506.png?nolink |}}
</modal>

<modal id="22" size="lg" title="IWR1 50μM R08 exp495  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp495.png?nolink |}}
</modal>

<modal id="23" size="lg" title="L-74142 5μM R03 exp131  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp131_vs_exp149.png?nolink |}}
</modal>

<modal id="24" size="lg" title="SB202190 10μM R03 exp148  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp148_vs_exp149.png?nolink |}}
</modal>

<modal id="25" size="lg" title="FTY720 3μM R08 exp483  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp483.png?nolink |}}
</modal>

<modal id="26" size="lg" title="CAY10603 0.55μM R08 exp467  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp467.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Daidzin 10μM R06 exp280  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp280.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|CDP-choline pathway|296.05|CEPT1,CHKA,PCYT1A|
|sphingoid metabolic process|88.82|KDSR,SPTSSA,SPTLC2|
|phosphatidylcholine biosynthetic process|74.01|CEPT1,CHKA,PCYT1A|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>