SGC2043 10μM R03 exp152 [The Human Chemical-Genetic Interaction Map Project]

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====== SGC2043 10μM R03 exp152 ======
==== Mechanism of Action ====
Inactive control for A-196 (SUV420H1/H2 inhibitor)
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 373.29
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C19H18Cl2N4
{{:chemogenomics:structures:chem-0103.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Structural Genomics Consortium
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C19H18Cl2N4 373.09813; found 373.10112
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** SGC2043
    * **<color #00a2e8>Min:</color>** -1.6023; **<color #00a2e8>Max:</color>** 41.8559
{{:chemogenomics:dose_response:dr_123.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |12.7645    |
| IC30  |16.9874    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.3
    * **<color #00a2e8>Numbers of reads</color>**: 12851647


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/SGC2043_10uM_Round-3_exp152.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='SGC2043 10μM R03 exp152'>
{{:chemogenomics:cranks_plots:exp152.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:F:FLVCR1|FLVCR1]]|-4.60|<0.01|
|[[:human_genes:S:SLC7A5|SLC7A5]]|-2.69|0.06|
|[[:human_genes:P:PDSS1|PDSS1]]|-2.67|0.18|
|[[:human_genes:P:PGM3|PGM3]]|-2.36|0.24|
|[[:human_genes:R:RFC2|RFC2]]|-2.36|0.33|
|[[:human_genes:C:COG6|COG6]]|-2.33|0.18|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-2.33|0.18|
|[[:human_genes:S:SEC62|SEC62]]|-2.31|0.18|
|[[:human_genes:L:LLGL1|LLGL1]]|-2.29|0.18|
|[[:human_genes:D:DCAF15|DCAF15]]|-2.27|0.40|
|[[:human_genes:G:GCLC|GCLC]]|-2.23|0.32|
|[[:human_genes:C:COQ9|COQ9]]|-2.20|0.25|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.16|0.28|
|[[:human_genes:C:COG7|COG7]]|-2.11|0.32|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.07|0.33|
|[[:human_genes:P:PLEKHB1|PLEKHB1]]|-2.02|0.39|
|[[:human_genes:I:IL12B|IL12B]]|-2.02|0.39|
|[[:human_genes:K:KCNS1|KCNS1]]|-1.98|0.43|
|[[:human_genes:W:WBSCR16|WBSCR16]]|-1.98|0.63|
|[[:human_genes:F:FNTB|FNTB]]|-1.95|0.57|
|[[:human_genes:P:PPARGC1B|PPARGC1B]]|-1.94|0.60|
|[[:human_genes:E:EEFSEC|EEFSEC]]|-1.93|0.57|
|[[:human_genes:P:PCK2|PCK2]]|-1.92|0.53|
|[[:human_genes:T:TMEM242|TMEM242]]|-1.91|0.53|
|[[:human_genes:Z:ZMYND12|ZMYND12]]|-1.91|0.53|
|[[:human_genes:A:ALG1|ALG1]]|-1.91|0.57|
|[[:human_genes:S:SRF|SRF]]|-1.91|0.57|
|[[:human_genes:L:LZTR1|LZTR1]]|-1.90|0.54|
|[[:human_genes:A:ATP6V1G1|ATP6V1G1]]|-1.89|0.57|
|[[:human_genes:N:NDUFA10|NDUFA10]]|-1.88|0.57|
|[[:human_genes:M:MFAP1|MFAP1]]|1.88|0.61|
|[[:human_genes:G:GPT|GPT]]|1.89|0.55|
|[[:human_genes:N:NIPBL|NIPBL]]|1.89|0.61|
|[[:human_genes:O:OR52E6|OR52E6]]|1.89|0.55|
|[[:human_genes:V:VHLL|VHLL]]|1.90|0.55|
|[[:human_genes:R:RBPMS|RBPMS]]|1.91|0.55|
|[[:human_genes:R:RPP40|RPP40]]|1.92|0.55|
|[[:human_genes:D:DNAAF1|DNAAF1]]|1.92|0.55|
|[[:human_genes:R:RPL11|RPL11]]|1.92|0.63|
|[[:human_genes:H:HMGB2|HMGB2]]|1.93|0.55|
|[[:human_genes:C:CDC23|CDC23]]|1.94|0.55|
|[[:human_genes:C:CDC42BPA|CDC42BPA]]|1.95|0.55|
|[[:human_genes:L:LCN1|LCN1]]|1.97|0.55|
|[[:human_genes:K:KIF23|KIF23]]|1.98|0.62|
|[[:human_genes:S:SLC5A1|SLC5A1]]|1.99|0.55|
|[[:human_genes:C:CD52|CD52]]|2.02|0.55|
|[[:human_genes:T:TAS2R13|TAS2R13]]|2.02|0.55|
|[[:human_genes:C:COPE|COPE]]|2.05|0.72|
|[[:human_genes:D:DROSHA|DROSHA]]|2.08|0.56|
|[[:human_genes:T:TMEM2|TMEM2]]|2.11|0.55|
|[[:human_genes:C:CTTNBP2|CTTNBP2]]|2.12|0.55|
|[[:human_genes:P:POLR3B|POLR3B]]|2.14|0.55|
|[[:human_genes:F:FERMT2|FERMT2]]|2.15|0.55|
|[[:human_genes:F:FAM47E|FAM47E]]|2.17|0.55|
|[[:human_genes:D:DARS|DARS]]|2.17|0.55|
|[[:human_genes:S:SHFM1|SHFM1]]|2.21|0.60|
|[[:human_genes:T:TPX2|TPX2]]|2.32|0.55|
|[[:human_genes:F:FAM104B|FAM104B]]|2.35|0.48|
|[[:human_genes:O:OR10G3|OR10G3]]|2.41|0.52|
|[[:human_genes:C:CAPZA2|CAPZA2]]|2.54|0.31|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.068|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp131|L-74142 5μM R03 exp131]]|0.064|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.061|<button type="primary" size="small" modal="3">View</button>|
</modal>


<modal id="1" size="lg" title="SB203580 25μM R03 exp149  vs  SGC2043 10μM R03 exp152">
{{:chemogenomics:comparison_plots:exp149_vs_exp152.png?nolink |}}
</modal>

<modal id="2" size="lg" title="L-74142 5μM R03 exp131  vs  SGC2043 10μM R03 exp152">
{{:chemogenomics:comparison_plots:exp131_vs_exp152.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Prochlorperazine 5.2μM R02 exp77  vs  SGC2043 10μM R03 exp152">
{{:chemogenomics:comparison_plots:exp152_vs_exp77.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>