SGC2096 2.6μM R03 exp153 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== SGC2096 2.6μM R03 exp153 ======
==== Mechanism of Action ====
Inactive control for GSK591 (PRMT5 inhibitor)
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 332.45
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C18H28N4O2
{{:chemogenomics:structures:chem-0104.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Structural Genomics Consortium
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C18H28N4O2 333.2285; found 333.23036
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** SGC2096
    * **<color #00a2e8>Min:</color>** -12.4183; **<color #00a2e8>Max:</color>** 24.7337
{{:chemogenomics:dose_response:dr_124.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 2.6µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 8.2
    * **<color #00a2e8>Numbers of reads</color>**: 9235230


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/SGC2096_2.6uM_Round-3_exp153.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='SGC2096 2.6μM R03 exp153'>
{{:chemogenomics:cranks_plots:exp153.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Z:ZSCAN12|ZSCAN12]]|-2.50|0.73|
|[[:human_genes:T:TYMSOS|TYMSOS]]|-2.49|0.83|
|[[:human_genes:C:COL16A1|COL16A1]]|-2.49|0.38|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.36|0.60|
|[[:human_genes:R:RNASEH1|RNASEH1]]|-2.25|0.60|
|[[:human_genes:A:ALDOC|ALDOC]]|-2.24|0.60|
|[[:human_genes:M:MFSD2B|MFSD2B]]|-2.23|0.60|
|[[:human_genes:P:PRAMEF25|PRAMEF25]]|-2.22|0.91|
|[[:human_genes:P:PRAMEF26|PRAMEF26]]|-2.22|0.91|
|[[:human_genes:Z:ZNF34|ZNF34]]|-2.15|0.60|
|[[:human_genes:R:RBM14|RBM14]]|-2.13|0.73|
|[[:human_genes:R:RBM14-RBM4|RBM14-RBM4]]|-2.10|0.75|
|[[:human_genes:D:DNAH8|DNAH8]]|-2.09|0.60|
|[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|-2.04|0.91|
|[[:human_genes:C:C20orf26|C20orf26]]|-2.01|0.60|
|[[:human_genes:Z:ZCCHC10|ZCCHC10]]|-2.01|0.60|
|[[:human_genes:P:PLA2G2F|PLA2G2F]]|-2.00|0.60|
|[[:human_genes:G:GCLC|GCLC]]|-1.99|0.73|
|[[:human_genes:L:LITAF|LITAF]]|-1.99|0.60|
|[[:human_genes:H:HGS|HGS]]|-1.98|0.60|
|[[:human_genes:F:FH|FH]]|-1.97|0.80|
|[[:human_genes:P:PGGT1B|PGGT1B]]|-1.96|0.60|
|[[:human_genes:S:SLC31A2|SLC31A2]]|-1.95|0.60|
|[[:human_genes:Z:ZBTB21|ZBTB21]]|-1.95|0.60|
|[[:human_genes:M:MKL1|MKL1]]|-1.94|0.75|
|[[:human_genes:P:PDE8A|PDE8A]]|-1.84|0.81|
|[[:human_genes:E:EBF3|EBF3]]|-1.84|0.75|
|[[:human_genes:G:GBP7|GBP7]]|-1.84|0.75|
|[[:human_genes:D:DHRS4L1|DHRS4L1]]|-1.84|0.83|
|[[:human_genes:F:FAM189B|FAM189B]]|-1.83|0.75|
|[[:human_genes:K:KLF10|KLF10]]|1.87|0.70|
|[[:human_genes:S:SEC24B|SEC24B]]|1.88|0.70|
|[[:human_genes:T:TRPC7|TRPC7]]|1.90|0.69|
|[[:human_genes:E:EIF5B|EIF5B]]|1.90|0.90|
|[[:human_genes:C:CTTNBP2|CTTNBP2]]|1.94|0.60|
|[[:human_genes:R:RNASE3|RNASE3]]|1.94|0.60|
|[[:human_genes:C:C7orf73|C7orf73]]|1.94|0.88|
|[[:human_genes:H:HLA-DQA1|HLA-DQA1]]|1.95|0.60|
|[[:human_genes:P:PIP4K2B|PIP4K2B]]|1.95|0.77|
|[[:human_genes:C:CPSF2|CPSF2]]|1.95|0.88|
|[[:human_genes:I:ILF3|ILF3]]|1.98|0.88|
|[[:human_genes:M:MYO1H|MYO1H]]|1.98|0.70|
|[[:human_genes:D:DDR2|DDR2]]|1.99|0.60|
|[[:human_genes:S:SMIM19|SMIM19]]|2.02|0.60|
|[[:human_genes:P:PSMD13|PSMD13]]|2.02|0.77|
|[[:human_genes:H:HOXC10|HOXC10]]|2.07|0.77|
|[[:human_genes:C:CNOT2|CNOT2]]|2.07|0.60|
|[[:human_genes:C:CXCL6|CXCL6]]|2.08|0.60|
|[[:human_genes:E:ERH|ERH]]|2.11|0.60|
|[[:human_genes:P:PTPDC1|PTPDC1]]|2.12|0.60|
|[[:human_genes:K:KSR1|KSR1]]|2.14|0.60|
|[[:human_genes:K:KIN|KIN]]|2.19|0.76|
|[[:human_genes:P:PPP1R15A|PPP1R15A]]|2.21|0.60|
|[[:human_genes:P:PRPF18|PRPF18]]|2.22|0.81|
|[[:human_genes:O:OR5AR1|OR5AR1]]|2.22|0.35|
|[[:human_genes:M:MB|MB]]|2.24|0.35|
|[[:human_genes:R:RTN4|RTN4]]|2.31|0.31|
|[[:human_genes:D:DGCR14|DGCR14]]|2.45|0.31|
|[[:human_genes:P:PAFAH2|PAFAH2]]|2.60|0.11|
|[[:human_genes:C:CLSPN|CLSPN]]|3.31|0.11|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>