Q15 1 to 2μM on day4 R04 exp164 [The Human Chemical-Genetic Interaction Map Project]

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====== Q15 1 to 2μM on day4 R04 exp164 ======
==== Mechanism of Action ====
Putative condensin inhibitor
  * **<color #00a2e8>Class / Subclass 1:</color>** Cell Cycle / Chromosome Dynamics Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1071780-64-7
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 584.0421
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C31H27ClFN7O2
{{:chemogenomics:structures:chem-0055.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - University of Montreal - Chemistry Platform
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C31H27ClFN7O2 584.19716; found 584.19427
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Q15
    * **<color #00a2e8>Min:</color>** -15.2028; **<color #00a2e8>Max:</color>** 99.7587
{{:chemogenomics:dose_response:dr_22.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |2.4826    |
| IC30  |2.6903    |
| IC40  |2.8735    |
| IC50  |3.0525    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 04
    * **<color #00a2e8>Dose</color>**: 1-2µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.2
    * **<color #00a2e8>Numbers of reads</color>**: 18303857


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|43/2|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Q15_1-2day4uM_Round-4_exp164.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Q15 1 to 2μM on day4 R04 exp164'>
{{:chemogenomics:cranks_plots:exp164.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:F:FLVCR1|FLVCR1]]|-4.68|<0.01|
|[[:human_genes:P:PITPNB|PITPNB]]|-4.67|<0.01|
|[[:human_genes:V:VKORC1L1|VKORC1L1]]|-4.66|<0.01|
|[[:human_genes:O:OSBPL9|OSBPL9]]|-4.48|<0.01|
|[[:human_genes:S:SCAP|SCAP]]|-4.21|<0.01|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-3.77|<0.01|
|[[:human_genes:S:SPTLC2|SPTLC2]]|-3.75|<0.01|
|[[:human_genes:C:CHKA|CHKA]]|-3.72|<0.01|
|[[:human_genes:U:UNC50|UNC50]]|-3.71|<0.01|
|[[:human_genes:K:KDSR|KDSR]]|-3.60|<0.01|
|[[:human_genes:S:SGMS1|SGMS1]]|-3.43|<0.01|
|[[:human_genes:C:CEPT1|CEPT1]]|-3.37|<0.01|
|[[:human_genes:S:SPTLC1|SPTLC1]]|-3.18|<0.01|
|[[:human_genes:E:ELOVL1|ELOVL1]]|-3.14|<0.01|
|[[:human_genes:P:PPP3R1|PPP3R1]]|-3.13|<0.01|
|[[:human_genes:A:ACSL4|ACSL4]]|-3.13|<0.01|
|[[:human_genes:R:RAB1B|RAB1B]]|-3.05|<0.01|
|[[:human_genes:R:RAB7A|RAB7A]]|-3.05|<0.01|
|[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|-3.04|0.19|
|[[:human_genes:M:MMD|MMD]]|-3.03|<0.01|
|[[:human_genes:A:ATP9B|ATP9B]]|-2.99|<0.01|
|[[:human_genes:M:MARCH6|MARCH6]]|-2.97|<0.01|
|[[:human_genes:P:PCYT2|PCYT2]]|-2.89|<0.01|
|[[:human_genes:I:ITFG1|ITFG1]]|-2.76|<0.01|
|[[:human_genes:E:EPT1|EPT1]]|-2.75|<0.01|
|[[:human_genes:L:LDLR|LDLR]]|-2.72|<0.01|
|[[:human_genes:D:DHX36|DHX36]]|-2.71|<0.01|
|[[:human_genes:O:OSBPL11|OSBPL11]]|-2.69|<0.01|
|[[:human_genes:O:OSBPL8|OSBPL8]]|-2.65|<0.01|
|[[:human_genes:A:ACTR2|ACTR2]]|-2.64|0.01|
|[[:human_genes:D:DNM2|DNM2]]|2.02|0.72|
|[[:human_genes:P:PAQR5|PAQR5]]|2.02|0.36|
|[[:human_genes:A:ANKLE1|ANKLE1]]|2.05|0.33|
|[[:human_genes:Z:ZNF708|ZNF708]]|2.06|0.56|
|[[:human_genes:A:ACSL3|ACSL3]]|2.06|0.54|
|[[:human_genes:D:DCAF8L2|DCAF8L2]]|2.10|0.28|
|[[:human_genes:N:NDC1|NDC1]]|2.11|0.28|
|[[:human_genes:C:CD8A|CD8A]]|2.11|0.38|
|[[:human_genes:G:GPR137|GPR137]]|2.12|0.28|
|[[:human_genes:U:UBE2QL1|UBE2QL1]]|2.12|0.38|
|[[:human_genes:F:FAM98B|FAM98B]]|2.13|0.28|
|[[:human_genes:R:RPS28|RPS28]]|2.17|0.56|
|[[:human_genes:I:INSIG1|INSIG1]]|2.19|0.32|
|[[:human_genes:S:SNRPD1|SNRPD1]]|2.20|0.56|
|[[:human_genes:K:KCTD5|KCTD5]]|2.25|0.16|
|[[:human_genes:C:CEBPZ|CEBPZ]]|2.25|0.56|
|[[:human_genes:P:POLR2L|POLR2L]]|2.27|0.56|
|[[:human_genes:Z:ZNF235|ZNF235]]|2.28|0.16|
|[[:human_genes:S:SLN|SLN]]|2.33|0.57|
|[[:human_genes:C:CITED2|CITED2]]|2.34|0.13|
|[[:human_genes:N:NR2C2AP|NR2C2AP]]|2.39|0.16|
|[[:human_genes:C:COPS7B|COPS7B]]|2.39|0.13|
|[[:human_genes:G:GGA3|GGA3]]|2.47|0.13|
|[[:human_genes:N:NPIPB3|NPIPB3]]|2.52|0.56|
|[[:human_genes:E:EIF5B|EIF5B]]|2.57|0.55|
|[[:human_genes:C:CHP1|CHP1]]|2.68|0.09|
|[[:human_genes:A:AGPAT6|AGPAT6]]|2.74|0.04|
|[[:human_genes:W:WIBG|WIBG]]|2.83|0.05|
|[[:human_genes:T:TRIM44|TRIM44]]|2.93|0.04|
|[[:human_genes:C:C18orf32|C18orf32]]|3.47|0.13|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|0.164|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|0.103|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|0.089|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.07|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.062|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.061|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.059|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.056|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.056|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.139|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.109|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.072|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.071|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|0.069|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.063|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|0.062|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|0.061|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp131|L-74142 5μM R03 exp131]]|0.061|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.061|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.06|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.059|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|0.052|<button type="primary" size="small" modal="22">View</button>|
</modal>


<modal id="1" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp164_vs_exp79.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Vemurafenib 6.6μM R02 exp89">
{{:chemogenomics:comparison_plots:exp164_vs_exp89.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp164_vs_exp434.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp164.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp164_vs_exp416.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp164_vs_exp84.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp164_vs_exp530.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp164_vs_exp422.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp164_vs_exp90.png?nolink |}}
</modal>

<modal id="10" size="lg" title="BH1 1μM R04 exp169  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp169.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Clomiphene 4.4μM R02 exp68  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp68.png?nolink |}}
</modal>

<modal id="12" size="lg" title="BS-181 20μM R08 exp461  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp461.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp454.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Lapatinib 5μM R01 exp47  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp47.png?nolink |}}
</modal>

<modal id="15" size="lg" title="NN-Dimethylsphingosine 2.5μM R08 exp508  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp508.png?nolink |}}
</modal>

<modal id="16" size="lg" title="CFI-400945 25μM R08 exp469  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp469.png?nolink |}}
</modal>

<modal id="17" size="lg" title="IU1-47 25μM R04 exp182  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp182.png?nolink |}}
</modal>

<modal id="18" size="lg" title="L-74142 5μM R03 exp131  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp131_vs_exp164.png?nolink |}}
</modal>

<modal id="19" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp445.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp344.png?nolink |}}
</modal>

<modal id="21" size="lg" title="FTY720 3μM R08 exp483  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp483.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Monensin 0.3μM R08 exp507  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp507.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|sphinganine metabolic process|613.85|SPTLC2,SPTLC1|
|CDP-choline pathway|306.93|PCYT1A,CHKA,CEPT1|
|phosphatidylethanolamine biosynthetic process|272.82|CHKA,CEPT1,PCYT2,SELENOI|
|sphingomyelin biosynthetic process|184.16|SPTLC2,SGMS1,SPTLC1|
|sphingomyelin metabolic process|102.31|SPTLC2,SGMS1,SPTLC1|
|phosphatidylethanolamine metabolic process|94.44|CHKA,CEPT1,PCYT2,SELENOI|
|ceramide biosynthetic process|45.47|SPTLC2,SGMS1,SPTLC1,ELOVL1|
|sterol binding|40.25|OSBPL9,SCAP,OSBPL11,OSBPL8|
|sphingolipid biosynthetic process|30.39|SPTLC2,KDSR,SGMS1,SPTLC1,ELOVL1|
|membrane lipid biosynthetic process|21.92|SPTLC2,KDSR,SGMS1,SPTLC1,ELOVL1|
|phospholipid biosynthetic process|21.08|PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,PCYT2,SELENOI|
|phospholipid metabolic process|15.97|PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,PCYT2,SELENOI,OSBPL8|
|glycerophospholipid metabolic process|13.44|PCYT1A,CHKA,CEPT1,PCYT2,SELENOI,OSBPL8|
|lipid transport|12.60|PITPNB,OSBPL9,CHKA,ATP9B,LDLR,OSBPL11,OSBPL8|
|organophosphate biosynthetic process|11.87|PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI|
|lipid biosynthetic process|11.78|OSBPL9,PCYT1A,SPTLC2,CHKA,KDSR,SGMS1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI|
|lipid localization|11.52|PITPNB,OSBPL9,CHKA,ATP9B,LDLR,OSBPL11,OSBPL8|
|cellular lipid metabolic process|9.05|SCAP,PCYT1A,SPTLC2,CHKA,KDSR,SGMS1,CEPT1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI,OSBPL8|
|organophosphate metabolic process|7.83|PCYT1A,SPTLC2,CHKA,SGMS1,CEPT1,SPTLC1,ELOVL1,ACSL4,PCYT2,SELENOI,OSBPL8|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>