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Ask your administrator if you think this is wrong. ====== DABN 2μM R00 exp16 ====== ==== Mechanism of Action ==== Unknown * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit ==== Technical Notes ==== <accordion collapsed='true'> <panel title='Compound References' collapsed='true'> * **<color #00a2e8>PubChem Name:</color>** %%[1,1'-Binaphthalene]-2,2'-diamine%% * **<color #00a2e8>Synonyms:</color>** N/A * **<color #00a2e8>CAS #:</color>** 4488-22-6 * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/20571|20571]] * **<color #00a2e8>IUPAC:</color>** %%1-(2-aminonaphthalen-1-yl)naphthalen-2-amine%% * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H16N2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12H,21-22H2 * **<color #00a2e8>INCHI Key:</color>** DDAPSNKEOHDLKB-UHFFFAOYSA-N * **<color #00a2e8>Molecular Weight:</color>** 284.4 * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)N)N * **<color #00a2e8>Isomeric SMILES:</color>** N/A * **<color #00a2e8>Molecular Formula:</color>** C20H16N2 {{:chemogenomics:structures:chem-0009.svg?nolink}} </panel> <panel title='Compound Supplier' collapsed='true'> * **<color #00a2e8>Supplier Name:</color>** Chem-Impex International * **<color #00a2e8>Catalog #:</color>** 24623 * **<color #00a2e8>Lot #:</color>** 001702-20140303 </panel> <panel title='Compound Characterization' collapsed='true'> * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H16N2 285.13862; found 285.13894 </panel> <panel title='Dose Response Curve' collapsed='true'> * **<color #00a2e8>Platform ID:</color>** DABN * **<color #00a2e8>Min:</color>** -10.2228; **<color #00a2e8>Max:</color>** 85.8979 {{:chemogenomics:dose_response:dr_262.png?nolink&500 |}} \\ \\ \\ \\ |< 300px 100px 200px >| ^ IC ^ Concentration (µM) ^ | IC10 |N/A | | IC20 |6.0249 | | IC30 |6.1377 | | IC40 |6.2318 | | IC50 |6.3193 | | IC60 |N/A | | IC70 |N/A | | IC80 |N/A | | IC90 |N/A | \\ </panel> </accordion> ==== Screen Summary ==== * **<color #00a2e8>Round</color>**: 00 * **<color #00a2e8>Dose</color>**: 2µM * **<color #00a2e8>Days of incubation</color>**: 8 * **<color #00a2e8>Doublings</color>**: 6.4 * **<color #00a2e8>Numbers of reads</color>**: 10428304 ==== Screen Results ==== ^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^ |1/1|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/DABN_2uM_Round-0_exp16.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>| <modal id='ScorePlot' size='lg' title='DABN 2μM R00 exp16'> {{:chemogenomics:cranks_plots:exp16.png?nolink}} </modal> <modal id="modal_hits" size="sm" title="Top 30 S/R Genes"> ^Gene^CRANKS Score^FDR^ |[[:human_genes:A:ASB3|ASB3]]|-2.86|0.05| |[[:human_genes:O:ORC3|ORC3]]|-2.50|0.42| |[[:human_genes:C:CEPT1|CEPT1]]|-2.45|0.24| |[[:human_genes:S:SENP6|SENP6]]|-2.39|0.24| |[[:human_genes:T:TRPM4|TRPM4]]|-2.36|0.42| |[[:human_genes:D:DCAF15|DCAF15]]|-2.28|0.43| |[[:human_genes:C:COX8C|COX8C]]|-2.18|0.43| |[[:human_genes:P:PARL|PARL]]|-2.15|0.43| |[[:human_genes:L:LMLN|LMLN]]|-2.11|0.43| |[[:human_genes:O:OR4F4|OR4F4]]|-2.08|0.43| |[[:human_genes:N:NUDT5|NUDT5]]|-2.08|0.43| |[[:human_genes:V:VAC14|VAC14]]|-2.05|0.43| |[[:human_genes:R:RAB11FIP3|RAB11FIP3]]|-2.03|0.43| |[[:human_genes:D:DPAGT1|DPAGT1]]|-2.03|0.43| |[[:human_genes:T:TXNL4B|TXNL4B]]|-2.02|0.43| |[[:human_genes:C:COX4I1|COX4I1]]|-2.01|0.43| |[[:human_genes:N:NKX6-2|NKX6-2]]|-1.98|0.43| |[[:human_genes:C:CRELD1|CRELD1]]|-1.98|0.64| |[[:human_genes:S:SPRN|SPRN]]|-1.97|0.43| |[[:human_genes:Z:ZMYND19|ZMYND19]]|-1.97|0.43| |[[:human_genes:Z:ZNHIT1|ZNHIT1]]|-1.96|0.43| |[[:human_genes:P:PGGT1B|PGGT1B]]|-1.95|0.43| |[[:human_genes:S:SCFD1|SCFD1]]|-1.94|0.65| |[[:human_genes:K:KIAA1432|KIAA1432]]|-1.92|0.46| |[[:human_genes:Z:ZIC2|ZIC2]]|-1.92|0.46| |[[:human_genes:C:CHMP1A|CHMP1A]]|-1.89|0.64| |[[:human_genes:F:FARS2|FARS2]]|-1.88|0.66| |[[:human_genes:K:KRT6B|KRT6B]]|-1.88|0.54| |[[:human_genes:T:TXNL4A|TXNL4A]]|-1.86|0.73| |[[:human_genes:R:RFC5|RFC5]]|-1.86|0.58| |[[:human_genes:R:RPS28|RPS28]]|2.13|0.52| |[[:human_genes:R:RUVBL1|RUVBL1]]|2.13|0.52| |[[:human_genes:M:MYO1H|MYO1H]]|2.13|0.33| |[[:human_genes:P:PIGW|PIGW]]|2.15|0.30| |[[:human_genes:W:WEE1|WEE1]]|2.15|0.48| |[[:human_genes:G:GPR156|GPR156]]|2.17|0.26| |[[:human_genes:L:LECT1|LECT1]]|2.18|0.26| |[[:human_genes:C:CNTNAP2|CNTNAP2]]|2.21|0.26| |[[:human_genes:R:RFC1|RFC1]]|2.25|0.50| |[[:human_genes:C:C19orf53|C19orf53]]|2.26|0.30| |[[:human_genes:Z:ZNF675|ZNF675]]|2.28|0.26| |[[:human_genes:A:ADAM18|ADAM18]]|2.28|0.30| |[[:human_genes:P:PNPLA8|PNPLA8]]|2.30|0.30| |[[:human_genes:M:MYCBP2|MYCBP2]]|2.30|0.26| |[[:human_genes:E:ECD|ECD]]|2.31|0.30| |[[:human_genes:P:PSMA1|PSMA1]]|2.37|0.39| |[[:human_genes:T:TPX2|TPX2]]|2.39|0.39| |[[:human_genes:N:NUP188|NUP188]]|2.41|0.26| |[[:human_genes:N:NPIPB3|NPIPB3]]|2.46|0.43| |[[:human_genes:P:PLEKHA4|PLEKHA4]]|2.48|0.17| |[[:human_genes:R:RPL14|RPL14]]|2.56|0.33| |[[:human_genes:S:SPATA12|SPATA12]]|2.57|0.07| |[[:human_genes:N:NUP93|NUP93]]|2.58|0.33| |[[:human_genes:C:CEP76|CEP76]]|2.63|0.06| |[[:human_genes:C:CALCOCO2|CALCOCO2]]|2.66|0.06| |[[:human_genes:C:CKAP5|CKAP5]]|2.82|0.33| |[[:human_genes:S:SMU1|SMU1]]|2.92|0.26| |[[:human_genes:A:ANXA5|ANXA5]]|2.94|0.03| |[[:human_genes:R:RPS13|RPS13]]|3.04|0.08| |[[:human_genes:N:NDC80|NDC80]]|3.12|0.26| </modal> <modal id="modal_screen_similarity" size="lg" title="Correlated Screens"> ^Screen^Correlation^Plot^ |[[:results:exp32|Rifampicin 10μM R00 exp32]]|0.07|<button type="primary" size="small" modal="1">View</button>| |[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|0.057|<button type="primary" size="small" modal="2">View</button>| |[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|0.055|<button type="primary" size="small" modal="3">View</button>| |[[:results:exp29|Rapamycin 1μM R00 exp29]]|0.052|<button type="primary" size="small" modal="4">View</button>| |[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|0.068|<button type="primary" size="small" modal="5">View</button>| |[[:results:exp11|CCCP 1μM R00 exp11]]|0.063|<button type="primary" size="small" modal="6">View</button>| |[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|0.062|<button type="primary" size="small" modal="7">View</button>| </modal> <modal id="1" size="lg" title="DABN 2μM R00 exp16 vs Rifampicin 10μM R00 exp32"> {{:chemogenomics:comparison_plots:exp16_vs_exp32.png?nolink |}} </modal> <modal id="2" size="lg" title="DABN 2μM R00 exp16 vs Nicotinamide 1000μM R03 exp101"> {{:chemogenomics:comparison_plots:exp101_vs_exp16.png?nolink |}} </modal> <modal id="3" size="lg" title="DABN 2μM R00 exp16 vs Wortmannin 0.5μM R00 exp37"> {{:chemogenomics:comparison_plots:exp16_vs_exp37.png?nolink |}} </modal> <modal id="4" size="lg" title="DABN 2μM R00 exp16 vs Rapamycin 1μM R00 exp29"> {{:chemogenomics:comparison_plots:exp16_vs_exp29.png?nolink |}} </modal> <modal id="5" size="lg" title="5-Fluorouracil 2μM R00 exp1 vs DABN 2μM R00 exp16"> {{:chemogenomics:comparison_plots:exp1_vs_exp16.png?nolink |}} </modal> <modal id="6" size="lg" title="CCCP 1μM R00 exp11 vs DABN 2μM R00 exp16"> {{:chemogenomics:comparison_plots:exp11_vs_exp16.png?nolink |}} </modal> <modal id="7" size="lg" title="Cycloheximide 0.02μM R00 exp14 vs DABN 2μM R00 exp16"> {{:chemogenomics:comparison_plots:exp14_vs_exp16.png?nolink |}} </modal> <modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal> <modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal> Last modified: 2026/01/15 21:36by 127.0.0.1