Hypoxia 5%O2 R04 exp191 [The Human Chemical-Genetic Interaction Map Project]

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====== Hypoxia 5%O2 R04 exp191 ======
==== Mechanism of Action ====
Reduced growth oxygen
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Stress Condition




==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 04
    * **<color #00a2e8>Dose</color>**: N/A
    * **<color #00a2e8>Days of incubation</color>**: 12
    * **<color #00a2e8>Doublings</color>**: N/A
    * **<color #00a2e8>Numbers of reads</color>**: 12250979


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|3/24|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Hypoxia_5pc_O2_Round-4_exp191.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Hypoxia 5%O2 R04 exp191'>
{{:chemogenomics:cranks_plots:exp191.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ADK|ADK]]|-6.20|<0.01|
|[[:human_genes:F:FASTKD5|FASTKD5]]|-3.05|0.02|
|[[:human_genes:U:UQCR10|UQCR10]]|-2.86|0.02|
|[[:human_genes:T:TBRG4|TBRG4]]|-2.60|0.08|
|[[:human_genes:A:ATP2B1|ATP2B1]]|-2.58|0.08|
|[[:human_genes:F:FNDC9|FNDC9]]|-2.55|0.08|
|[[:human_genes:P:PDK3|PDK3]]|-2.53|0.08|
|[[:human_genes:Z:ZNF579|ZNF579]]|-2.47|0.09|
|[[:human_genes:E:ETV6|ETV6]]|-2.45|0.08|
|[[:human_genes:S:SLC25A5|SLC25A5]]|-2.42|0.08|
|[[:human_genes:D:DAP3|DAP3]]|-2.39|0.08|
|[[:human_genes:Y:YARS2|YARS2]]|-2.30|0.10|
|[[:human_genes:A:ATP1A1|ATP1A1]]|-2.25|0.25|
|[[:human_genes:C:C2CD4B|C2CD4B]]|-2.25|0.20|
|[[:human_genes:Z:ZXDB|ZXDB]]|-2.22|0.15|
|[[:human_genes:M:MCM9|MCM9]]|-2.20|0.16|
|[[:human_genes:L:LMO2|LMO2]]|-2.15|0.20|
|[[:human_genes:T:TMEM161B|TMEM161B]]|-2.13|0.20|
|[[:human_genes:N:NUDT5|NUDT5]]|-2.12|0.25|
|[[:human_genes:S:STARD3|STARD3]]|-2.11|0.31|
|[[:human_genes:S:SETD6|SETD6]]|-2.11|0.20|
|[[:human_genes:C:C5orf64|C5orf64]]|-2.10|0.21|
|[[:human_genes:P:PNP|PNP]]|-2.09|0.21|
|[[:human_genes:G:GADD45A|GADD45A]]|-2.08|0.21|
|[[:human_genes:P:PCDHB12|PCDHB12]]|-2.07|0.21|
|[[:human_genes:G:GFM2|GFM2]]|-2.07|0.26|
|[[:human_genes:L:LIN28B|LIN28B]]|-2.06|0.21|
|[[:human_genes:S:SHOC2|SHOC2]]|-2.06|0.26|
|[[:human_genes:T:TUFM|TUFM]]|-2.04|0.37|
|[[:human_genes:U:UBE3D|UBE3D]]|-2.03|0.22|
|[[:human_genes:B:BRD1|BRD1]]|2.29|0.05|
|[[:human_genes:B:BRD2|BRD2]]|2.31|0.08|
|[[:human_genes:L:LANCL2|LANCL2]]|2.31|0.08|
|[[:human_genes:C:C4orf29|C4orf29]]|2.32|0.05|
|[[:human_genes:T:TMEM135|TMEM135]]|2.32|0.05|
|[[:human_genes:S:SUCLG1|SUCLG1]]|2.37|0.04|
|[[:human_genes:N:NME6|NME6]]|2.43|0.03|
|[[:human_genes:N:NCBP1|NCBP1]]|2.45|0.08|
|[[:human_genes:P:PYROXD1|PYROXD1]]|2.48|0.12|
|[[:human_genes:B:BRMS1|BRMS1]]|2.54|0.06|
|[[:human_genes:P:PRPS1|PRPS1]]|2.57|0.03|
|[[:human_genes:S:SLC25A32|SLC25A32]]|2.59|0.03|
|[[:human_genes:M:MGME1|MGME1]]|2.65|<0.01|
|[[:human_genes:M:MTHFD2|MTHFD2]]|2.77|<0.01|
|[[:human_genes:K:KLHDC2|KLHDC2]]|2.83|<0.01|
|[[:human_genes:I:IPPK|IPPK]]|2.88|<0.01|
|[[:human_genes:P:PHF6|PHF6]]|2.91|<0.01|
|[[:human_genes:Z:ZNF148|ZNF148]]|2.95|<0.01|
|[[:human_genes:N:NT5DC2|NT5DC2]]|3.06|<0.01|
|[[:human_genes:M:MDH1|MDH1]]|3.18|<0.01|
|[[:human_genes:S:SHMT2|SHMT2]]|3.21|<0.01|
|[[:human_genes:F:FAM96B|FAM96B]]|3.38|<0.01|
|[[:human_genes:S:SCAP|SCAP]]|3.43|<0.01|
|[[:human_genes:P:PHIP|PHIP]]|3.55|<0.01|
|[[:human_genes:A:ARID4B|ARID4B]]|3.93|<0.01|
|[[:human_genes:S:SLC25A36|SLC25A36]]|4.16|<0.01|
|[[:human_genes:D:DDX3X|DDX3X]]|4.20|<0.01|
|[[:human_genes:S:STARD7|STARD7]]|4.20|<0.01|
|[[:human_genes:P:PCGF1|PCGF1]]|4.38|<0.01|
|[[:human_genes:P:PDS5B|PDS5B]]|5.03|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|0.057|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|0.057|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|0.056|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp274|Citral 50μM R06 exp274]]|0.051|<button type="primary" size="small" modal="4">View</button>|
</modal>


<modal id="1" size="lg" title="Hypoxia 5%O2 R04 exp191  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp191_vs_exp248.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Hypoxia 5%O2 R04 exp191  vs  Phenformin 20μM R05 exp212">
{{:chemogenomics:comparison_plots:exp191_vs_exp212.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Doxycycline 10μM R00 exp18  vs  Hypoxia 5%O2 R04 exp191">
{{:chemogenomics:comparison_plots:exp18_vs_exp191.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Citral 50μM R06 exp274  vs  Hypoxia 5%O2 R04 exp191">
{{:chemogenomics:comparison_plots:exp191_vs_exp274.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|mitochondrial gene expression|27.52|FASTKD5,TBRG4,DAP3,YARS2,GFM2,TUFM|
|mitochondrial matrix|10.76|FASTKD5,TBRG4,PDK3,SLC25A5,DAP3,YARS2,GFM2,TUFM|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|folic acid metabolic process|118.39|SHMT2,MTHFD2,SLC25A32|
</modal>