Mdivi-1 15μM R05 exp217 [The Human Chemical-Genetic Interaction Map Project]

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====== Mdivi-1 15μM R05 exp217 ======
==== Mechanism of Action ====
Inhibits GTPase dynamin-related protein 1 (Drp1), impairs mitochondrial fission, also inhibits respiratory complex I
  * **<color #00a2e8>Class / Subclass 1:</color>** Organelle Function / Mitochondrial Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone%%
    * **<color #00a2e8>Synonyms:</color>** Mitochondrial division inhibitor 1
    * **<color #00a2e8>CAS #:</color>** 338967-87-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/3825829|3825829]]
    * **<color #00a2e8>IUPAC:</color>** %%3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
    * **<color #00a2e8>INCHI Key:</color>** NZJKEVWTYMOYOR-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 353.2
    * **<color #00a2e8>Canonical SMILES:</color>** COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C15H10Cl2N2O2S
{{:chemogenomics:structures:chem-0119.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** M0199
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C15H10Cl2N2O2S 352.99128; found 352.99118
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Mdivi-1
    * **<color #00a2e8>Min:</color>** -12.2946; **<color #00a2e8>Max:</color>** 89.1505
{{:chemogenomics:dose_response:dr_230.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |11.9377    |
| IC30  |14.5586    |
| IC40  |17.1308    |
| IC50  |19.8894    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 15µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.8
    * **<color #00a2e8>Numbers of reads</color>**: 17266778


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|38/66|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Mdivi-1_15uM_Round-5_exp217.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Mdivi-1 15μM R05 exp217'>
{{:chemogenomics:cranks_plots:exp217.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Y:YPEL5|YPEL5]]|-4.80|<0.01|
|[[:human_genes:S:SGOL2|SGOL2]]|-4.42|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-3.88|<0.01|
|[[:human_genes:T:TRIP13|TRIP13]]|-3.84|<0.01|
|[[:human_genes:A:ASPM|ASPM]]|-3.61|<0.01|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-3.48|<0.01|
|[[:human_genes:C:CALM2|CALM2]]|-3.39|<0.01|
|[[:human_genes:E:EDF1|EDF1]]|-3.37|<0.01|
|[[:human_genes:K:KNTC1|KNTC1]]|-3.31|<0.01|
|[[:human_genes:T:TSC1|TSC1]]|-3.28|<0.01|
|[[:human_genes:B:BRD1|BRD1]]|-3.21|<0.01|
|[[:human_genes:C:CNOT8|CNOT8]]|-3.18|<0.01|
|[[:human_genes:M:MSI2|MSI2]]|-3.06|<0.01|
|[[:human_genes:T:TUBB4B|TUBB4B]]|-2.97|<0.01|
|[[:human_genes:T:TACC3|TACC3]]|-2.93|<0.01|
|[[:human_genes:W:WDR26|WDR26]]|-2.93|<0.01|
|[[:human_genes:K:KIF18A|KIF18A]]|-2.89|<0.01|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.89|0.01|
|[[:human_genes:G:GTSE1|GTSE1]]|-2.86|<0.01|
|[[:human_genes:Z:ZWILCH|ZWILCH]]|-2.72|<0.01|
|[[:human_genes:D:DNTTIP1|DNTTIP1]]|-2.71|<0.01|
|[[:human_genes:T:TSC2|TSC2]]|-2.70|<0.01|
|[[:human_genes:G:GSK3B|GSK3B]]|-2.67|<0.01|
|[[:human_genes:E:ESCO2|ESCO2]]|-2.67|<0.01|
|[[:human_genes:C:CDK2|CDK2]]|-2.65|<0.01|
|[[:human_genes:A:ATP2B1|ATP2B1]]|-2.59|0.02|
|[[:human_genes:U:UBE4B|UBE4B]]|-2.56|0.01|
|[[:human_genes:P:PPIL1|PPIL1]]|-2.55|0.02|
|[[:human_genes:M:MAPRE1|MAPRE1]]|-2.51|0.03|
|[[:human_genes:P:PSME4|PSME4]]|-2.49|0.03|
|[[:human_genes:H:HAUS6|HAUS6]]|2.74|<0.01|
|[[:human_genes:T:TMEM161B|TMEM161B]]|2.75|<0.01|
|[[:human_genes:M:MEF2C|MEF2C]]|2.78|<0.01|
|[[:human_genes:C:CBX3|CBX3]]|2.80|<0.01|
|[[:human_genes:P:PPP2R5C|PPP2R5C]]|2.80|<0.01|
|[[:human_genes:T:TIPRL|TIPRL]]|2.83|<0.01|
|[[:human_genes:P:PPP1CC|PPP1CC]]|2.84|<0.01|
|[[:human_genes:N:NSD1|NSD1]]|2.85|<0.01|
|[[:human_genes:S:SNRK|SNRK]]|2.87|<0.01|
|[[:human_genes:C:CELF1|CELF1]]|2.97|<0.01|
|[[:human_genes:K:KATNA1|KATNA1]]|2.97|<0.01|
|[[:human_genes:S:SEC63|SEC63]]|2.98|<0.01|
|[[:human_genes:D:DCUN1D1|DCUN1D1]]|3.01|<0.01|
|[[:human_genes:P:PHF15|PHF15]]|3.04|<0.01|
|[[:human_genes:A:ATAT1|ATAT1]]|3.09|<0.01|
|[[:human_genes:P:PPME1|PPME1]]|3.24|<0.01|
|[[:human_genes:K:KIF2A|KIF2A]]|3.25|<0.01|
|[[:human_genes:T:TUBB|TUBB]]|3.70|<0.01|
|[[:human_genes:K:KATNB1|KATNB1]]|3.92|<0.01|
|[[:human_genes:N:NUMA1|NUMA1]]|4.12|<0.01|
|[[:human_genes:C:CLASP1|CLASP1]]|4.23|<0.01|
|[[:human_genes:H:HAUS3|HAUS3]]|4.27|<0.01|
|[[:human_genes:C:CCNF|CCNF]]|4.29|<0.01|
|[[:human_genes:P:PPP2R1A|PPP2R1A]]|4.53|<0.01|
|[[:human_genes:C:CLASP2|CLASP2]]|4.86|<0.01|
|[[:human_genes:K:KIF4A|KIF4A]]|4.97|<0.01|
|[[:human_genes:T:TP53|TP53]]|5.44|<0.01|
|[[:human_genes:K:KIF2C|KIF2C]]|5.88|<0.01|
|[[:human_genes:L:LCMT1|LCMT1]]|6.45|<0.01|
|[[:human_genes:K:KIF18B|KIF18B]]|7.96|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.216|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.133|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|0.104|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|0.097|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.095|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|0.09|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.066|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|0.059|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|0.058|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.054|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.051|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.207|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|0.121|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|0.12|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.118|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|0.105|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|0.098|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|0.097|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|0.085|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|0.084|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|0.083|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|0.065|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|0.061|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|0.051|<button type="primary" size="small" modal="24">View</button>|
</modal>


<modal id="1" size="lg" title="Mdivi-1 15μM R05 exp217  vs  UMK57 1μM R01 exp59">
{{:chemogenomics:comparison_plots:exp217_vs_exp59.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Mdivi-1 15μM R05 exp217  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp217.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Mdivi-1 15μM R05 exp217  vs  Taxol 0.004μM R03 exp103">
{{:chemogenomics:comparison_plots:exp103_vs_exp217.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Mdivi-1 15μM R05 exp217  vs  Vincristine 0.0005μM R04 exp190">
{{:chemogenomics:comparison_plots:exp190_vs_exp217.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Mdivi-1 15μM R05 exp217  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp217_vs_exp517.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Mdivi-1 15μM R05 exp217  vs  Vinblastine 0.002μM R01 exp60">
{{:chemogenomics:comparison_plots:exp217_vs_exp60.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Mdivi-1 15μM R05 exp217  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp217_vs_exp80.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Mdivi-1 15μM R05 exp217  vs  UMK57 0.6μM R03 exp107">
{{:chemogenomics:comparison_plots:exp107_vs_exp217.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Mdivi-1 15μM R05 exp217  vs  S-trityl-L-cysteine 0.5μM R05 exp243">
{{:chemogenomics:comparison_plots:exp217_vs_exp243.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Mdivi-1 15μM R05 exp217  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp217_vs_exp294.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Mdivi-1 15μM R05 exp217  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp217_vs_exp502.png?nolink |}}
</modal>

<modal id="12" size="lg" title="BML-284 0.09μM R08 exp460  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp460.png?nolink |}}
</modal>

<modal id="13" size="lg" title="2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp312.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Demecolcine 0.03μM R05 exp228  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp228.png?nolink |}}
</modal>

<modal id="15" size="lg" title="BVD-523 15μM R02 exp67  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp67.png?nolink |}}
</modal>

<modal id="16" size="lg" title="2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp311.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Colchicine 0.009μM R05 exp215  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp215_vs_exp217.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Combretastatin A4 0.002 to 0.003μM day4 R04 exp179  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp179_vs_exp217.png?nolink |}}
</modal>

<modal id="19" size="lg" title="HMS-I1 1μM R01 exp46  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp46.png?nolink |}}
</modal>

<modal id="20" size="lg" title="2-Methoxyestradiol 0.55μM R07 exp310  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp310.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Ixabepilone 0.004 to 0.005μM on day4 R04 exp184  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp184_vs_exp217.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Epothilone-B 0.0015μM R05 exp231  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp231.png?nolink |}}
</modal>

<modal id="23" size="lg" title="BI-6727 0.0125μM R03 exp97  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp97.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp45.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|kinetochore microtubule|95.23|KNTC1,KIF18A,ZWILCH|
|mitotic spindle checkpoint signaling|61.22|TRIP13,KNTC1,ZWILCH|
|mitotic spindle assembly checkpoint signaling|61.22|TRIP13,KNTC1,ZWILCH|
|spindle assembly checkpoint signaling|61.22|TRIP13,KNTC1,ZWILCH|
|spindle checkpoint signaling|59.11|TRIP13,KNTC1,ZWILCH|
|spindle microtubule|36.63|CALM2,KNTC1,KIF18A,ZWILCH,MAPRE1|
|cytoplasmic microtubule|27.21|TUBB4B,KIF18A,GTSE1,MAPRE1|
|mitotic cell cycle checkpoint signaling|23.42|TRIP13,KNTC1,GTSE1,ZWILCH,CDK2|
|spindle pole|20.17|YPEL5,ASPM,CALM2,KNTC1,TACC3,MAPRE1|
|mitotic spindle|19.37|YPEL5,ASPM,TUBB4B,TACC3,KIF18A,MAPRE1|
|cell cycle checkpoint signaling|18.31|TRIP13,KNTC1,GTSE1,ZWILCH,CDK2|
|spindle|12.42|YPEL5,ASPM,CALM2,KNTC1,TUBB4B,TACC3,KIF18A,ZWILCH,MAPRE1|
|chromosome segregation|12.23|SGO2,TRIP13,ASPM,KNTC1,KIF18A,ESCO2,MAPRE1|
|microtubule|10.53|ASPM,CALM2,KNTC1,TUBB4B,KIF18A,GTSE1,ZWILCH,MAPRE1|
|mitotic cell cycle process|9.93|TRIP13,CALM2,KNTC1,TACC3,KIF18A,GTSE1,ZWILCH,CDK2,MAPRE1|
|mitotic cell cycle|9.49|TRIP13,CALM2,KNTC1,TUBB4B,TACC3,KIF18A,GTSE1,ZWILCH,CDK2,MAPRE1|
|cell division|7.90|SGO2,ASPM,KNTC1,TACC3,ZWILCH,CDK2,MAPRE1|
|cell cycle process|7.85|SGO2,TRIP13,ASPM,CALM2,KNTC1,TACC3,KIF18A,GTSE1,ZWILCH,ESCO2,CDK2,MAPRE1|
|polymeric cytoskeletal fiber|6.92|ASPM,CALM2,KNTC1,TSC1,TUBB4B,KIF18A,GTSE1,ZWILCH,MAPRE1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|spindle microtubule|56.65|KIF18B,KIF4A,CLASP2,HAUS3,CLASP1,NUMA1,KIF2A,HAUS6|
|spindle assembly|35.47|KIF4A,CLASP2,HAUS3,CLASP1,NUMA1,KIF2A,HAUS6|
|mitotic sister chromatid segregation|32.49|KIF18B,KIF2C,KIF4A,CLASP2,PPP2R1A,CLASP1,KATNB1,KIF2A|
|sister chromatid segregation|31.56|KIF18B,KIF2C,KIF4A,CLASP2,PPP2R1A,CLASP1,KATNB1,KIF2A|
|spindle organization|28.90|KIF4A,CLASP2,PPP2R1A,HAUS3,CLASP1,NUMA1,TUBB,KIF2A,HAUS6|
|mitotic spindle|28.08|KIF18B,CLASP2,HAUS3,CLASP1,NUMA1,TUBB,ATAT1,KATNA1,HAUS6|
|microtubule binding|20.84|KIF18B,KIF2C,KIF4A,CLASP2,CLASP1,NUMA1,KATNB1,KIF2A,KATNA1,HAUS6|
|chromosome segregation|20.27|KIF18B,KIF2C,KIF4A,CLASP2,PPP2R1A,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,HAUS6|
|nuclear chromosome segregation|20.18|KIF18B,KIF2C,KIF4A,CLASP2,PPP2R1A,CLASP1,KATNB1,KIF2A|
|spindle|18.68|KIF18B,KIF2C,KIF4A,CLASP2,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,ATAT1,KATNA1,CBX3,HAUS6|
|microtubule|16.54|KIF18B,KIF2C,KIF4A,CLASP2,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,ATAT1,KATNA1,HAUS6|
|cell division|15.28|KIF18B,KIF2C,KIF4A,CLASP2,CCNF,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,KATNA1,PPP1CC,HAUS6|
|tubulin binding|15.09|KIF18B,KIF2C,KIF4A,CLASP2,CLASP1,NUMA1,KATNB1,KIF2A,KATNA1,HAUS6|
|microtubule cytoskeleton organization|14.35|KIF18B,KIF2C,KIF4A,CLASP2,PPP2R1A,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,ATAT1,KATNA1,HAUS6|
|mitotic cell cycle process|13.86|KIF18B,LCMT1,KIF2C,TP53,KIF4A,CLASP2,PPP2R1A,CCNF,CLASP1,NUMA1,KATNB1,KIF2A,PPME1|
|mitotic cell cycle|12.84|KIF18B,LCMT1,KIF2C,TP53,KIF4A,CLASP2,PPP2R1A,CCNF,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,PPME1|
|cell cycle process|10.11|KIF18B,LCMT1,KIF2C,TP53,KIF4A,CLASP2,PPP2R1A,CCNF,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,PPME1,HAUS6|
|microtubule-based process|9.91|KIF18B,KIF2C,KIF4A,CLASP2,PPP2R1A,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,ATAT1,KATNA1,HAUS6|
|polymeric cytoskeletal fiber|9.66|KIF18B,KIF2C,KIF4A,CLASP2,HAUS3,CLASP1,NUMA1,KATNB1,TUBB,KIF2A,ATAT1,KATNA1,HAUS6|
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