Cryptotanshinone 12μM R05 exp227 [The Human Chemical-Genetic Interaction Map Project]

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====== Cryptotanshinone 12μM R05 exp227 ======
==== Mechanism of Action ====
Putative acetylcholinesterase and STAT3 inhibitor
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Natural Product




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Cryptotanshinone%%
    * **<color #00a2e8>Synonyms:</color>** Cryptotanshinon; Tanshinone c
    * **<color #00a2e8>CAS #:</color>** 35825-57-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/160254|160254]]
    * **<color #00a2e8>IUPAC:</color>** %%(1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** GVKKJJOMQCNPGB-JTQLQIEISA-N
    * **<color #00a2e8>Molecular Weight:</color>** 296.4
    * **<color #00a2e8>Canonical SMILES:</color>** CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
    * **<color #00a2e8>Molecular Formula:</color>** C19H20O3
{{:chemogenomics:structures:chem-0132.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** 79852
    * **<color #00a2e8>Lot #:</color>** BCBQ7422V
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C19H20O3 297.14852; found 297.14755
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Crypto_Tanshione
    * **<color #00a2e8>Min:</color>** -4.8129; **<color #00a2e8>Max:</color>** 62.3766
{{:chemogenomics:dose_response:dr_200.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |8.3941    |
| IC30  |10.8771    |
| IC40  |13.4513    |
| IC50  |16.3465    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 12µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.4
    * **<color #00a2e8>Numbers of reads</color>**: 18040255


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|34/10|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Cryptotanshinone_12uM_Round-5_exp227.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Cryptotanshinone 12μM R05 exp227'>
{{:chemogenomics:cranks_plots:exp227.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SLC39A11|SLC39A11]]|-4.62|<0.01|
|[[:human_genes:N:NPRL2|NPRL2]]|-3.80|<0.01|
|[[:human_genes:P:PRDX1|PRDX1]]|-3.77|<0.01|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-3.37|<0.01|
|[[:human_genes:U:UNC50|UNC50]]|-3.21|<0.01|
|[[:human_genes:S:SLC39A9|SLC39A9]]|-3.17|<0.01|
|[[:human_genes:G:GPR107|GPR107]]|-3.15|<0.01|
|[[:human_genes:I:INTS12|INTS12]]|-3.10|<0.01|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-3.05|<0.01|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.87|<0.01|
|[[:human_genes:S:SEC31A|SEC31A]]|-2.81|<0.01|
|[[:human_genes:C:COMMD8|COMMD8]]|-2.79|<0.01|
|[[:human_genes:A:ATP2C1|ATP2C1]]|-2.76|<0.01|
|[[:human_genes:C:COG7|COG7]]|-2.74|<0.01|
|[[:human_genes:S:SLC25A28|SLC25A28]]|-2.66|<0.01|
|[[:human_genes:G:GID8|GID8]]|-2.63|0.01|
|[[:human_genes:A:ANKH|ANKH]]|-2.57|0.01|
|[[:human_genes:A:ARL1|ARL1]]|-2.56|0.01|
|[[:human_genes:T:TSC2|TSC2]]|-2.56|0.01|
|[[:human_genes:A:ARFRP1|ARFRP1]]|-2.55|0.01|
|[[:human_genes:C:CLCN3|CLCN3]]|-2.52|0.01|
|[[:human_genes:X:XPR1|XPR1]]|-2.51|0.01|
|[[:human_genes:C:CCDC22|CCDC22]]|-2.51|0.01|
|[[:human_genes:C:CNOT8|CNOT8]]|-2.51|0.01|
|[[:human_genes:S:STARD7|STARD7]]|-2.49|0.03|
|[[:human_genes:A:ATP6V1G1|ATP6V1G1]]|-2.49|0.03|
|[[:human_genes:M:MSI2|MSI2]]|-2.49|0.01|
|[[:human_genes:Y:YPEL5|YPEL5]]|-2.48|0.01|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.45|0.06|
|[[:human_genes:C:CHKA|CHKA]]|-2.42|0.02|
|[[:human_genes:P:PELO|PELO]]|2.05|0.30|
|[[:human_genes:P:POLA1|POLA1]]|2.05|0.66|
|[[:human_genes:R:RPS8|RPS8]]|2.05|0.71|
|[[:human_genes:S:STPG1|STPG1]]|2.11|0.28|
|[[:human_genes:U:UBN2|UBN2]]|2.13|0.18|
|[[:human_genes:N:NDUFB8|NDUFB8]]|2.16|0.41|
|[[:human_genes:S:SERPINC1|SERPINC1]]|2.19|0.25|
|[[:human_genes:F:FAM98B|FAM98B]]|2.22|0.12|
|[[:human_genes:I:IBA57|IBA57]]|2.23|0.12|
|[[:human_genes:T:TFDP1|TFDP1]]|2.25|0.28|
|[[:human_genes:P:PPA1|PPA1]]|2.30|0.28|
|[[:human_genes:B:BCL11A|BCL11A]]|2.31|0.08|
|[[:human_genes:T:TTF2|TTF2]]|2.32|0.08|
|[[:human_genes:N:NGDN|NGDN]]|2.35|0.30|
|[[:human_genes:C:C19orf43|C19orf43]]|2.38|0.11|
|[[:human_genes:R:RPS13|RPS13]]|2.40|0.49|
|[[:human_genes:R:RABGAP1|RABGAP1]]|2.42|0.06|
|[[:human_genes:R:RPSA|RPSA]]|2.45|0.47|
|[[:human_genes:T:TGFBR1|TGFBR1]]|2.46|0.05|
|[[:human_genes:M:MCL1|MCL1]]|2.46|0.08|
|[[:human_genes:S:SRM|SRM]]|2.49|0.08|
|[[:human_genes:S:SLFN11|SLFN11]]|2.56|0.03|
|[[:human_genes:T:TP53|TP53]]|2.72|0.03|
|[[:human_genes:N:NFYC|NFYC]]|2.77|0.01|
|[[:human_genes:G:GLRX5|GLRX5]]|2.91|0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.04|<0.01|
|[[:human_genes:S:SHMT2|SHMT2]]|3.09|0.01|
|[[:human_genes:M:METTL1|METTL1]]|3.17|<0.01|
|[[:human_genes:M:MAT2B|MAT2B]]|3.47|<0.01|
|[[:human_genes:A:ATIC|ATIC]]|4.90|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.073|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.073|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.072|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.07|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.063|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.062|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.061|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.06|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|0.059|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|0.059|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|0.057|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|0.057|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|0.054|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.053|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|0.053|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.051|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.086|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.077|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.065|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.064|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.063|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|0.062|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.059|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.058|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.056|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|0.054|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.053|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.053|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.053|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|0.051|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.051|<button type="primary" size="small" modal="31">View</button>|
</modal>


<modal id="1" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp227_vs_exp517.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp227_vs_exp329.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  FK-506 30μM R07 exp359">
{{:chemogenomics:comparison_plots:exp227_vs_exp359.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp227_vs_exp445.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp227_vs_exp350.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp227_vs_exp416.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp227_vs_exp90.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp227_vs_exp435.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Dynasore 7μM R08 exp436">
{{:chemogenomics:comparison_plots:exp227_vs_exp436.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Dynasore 10μM R04 exp180">
{{:chemogenomics:comparison_plots:exp180_vs_exp227.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Docosahexaenoic-acid 50μM R07 exp356">
{{:chemogenomics:comparison_plots:exp227_vs_exp356.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Vemurafenib 6.6μM R02 exp89">
{{:chemogenomics:comparison_plots:exp227_vs_exp89.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp227_vs_exp78.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp227_vs_exp85.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  Salubrinal 20μM R07 exp399">
{{:chemogenomics:comparison_plots:exp227_vs_exp399.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Cryptotanshinone 12μM R05 exp227  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp227_vs_exp483.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp454.png?nolink |}}
</modal>

<modal id="18" size="lg" title="BS-181 20μM R08 exp461  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp461.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Clomiphene 4.4μM R02 exp68  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp68.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BH1 1μM R04 exp169  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp169_vs_exp227.png?nolink |}}
</modal>

<modal id="21" size="lg" title="3-Bromopyruvate 7μM R04 exp175  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp175_vs_exp227.png?nolink |}}
</modal>

<modal id="22" size="lg" title="ABT-702 5μM plus Deferoxamine 11μM R07 exp321  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp321.png?nolink |}}
</modal>

<modal id="23" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp468.png?nolink |}}
</modal>

<modal id="24" size="lg" title="BVD-523 15μM R02 exp67  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp67.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp465.png?nolink |}}
</modal>

<modal id="26" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp334.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp466.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Artemisinin 50μM R08 exp450  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp450.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp457.png?nolink |}}
</modal>

<modal id="30" size="lg" title="2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp312.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp440.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|GATOR1 complex|591.79|NPRL2,NPRL3|
|protein localization to Golgi apparatus|61.22|COG7,ARL1,ARFRP1|
|transition metal ion transmembrane transporter activity|57.74|SLC39A11,SLC39A9,ATP2C1,SLC25A28|
|negative regulation of TORC1 signaling|57.74|NPRL2,PRKAA1,TSC2,NPRL3|
|negative regulation of TOR signaling|35.87|NPRL2,PRKAA1,TSC2,NPRL3|
|regulation of TORC1 signaling|27.52|NPRL2,PRKAA1,TSC2,NPRL3|
|transition metal ion transport|25.18|SLC39A11,SLC39A9,ATP2C1,SLC25A28|
|cellular response to starvation|17.51|NPRL2,PRKAA1,TSC2,XPR1,NPRL3|
|response to starvation|14.23|NPRL2,PRKAA1,TSC2,XPR1,NPRL3|
|cellular response to nutrient levels|12.81|NPRL2,PRKAA1,TSC2,XPR1,NPRL3|
|regulation of autophagy|10.20|NPRL2,ATP6V0A2,PRKAA1,TSC2,ATP6V1G1,NPRL3|
|inorganic ion homeostasis|10.10|SLC39A9,ATP6V0A2,ATP2C1,ANKH,XPR1,CCDC22,ATP6V1G1|
|cellular homeostasis|9.30|PRDX1,SLC39A9,ATP6V0A2,PRKAA1,ATP2C1,ANKH,CLCN3,XPR1,CCDC22,ATP6V1G1|
|intracellular chemical homeostasis|8.95|SLC39A9,ATP6V0A2,PRKAA1,ATP2C1,CLCN3,XPR1,CCDC22,ATP6V1G1|
|monoatomic cation homeostasis|8.72|SLC39A9,ATP6V0A2,ATP2C1,ANKH,CLCN3,CCDC22,ATP6V1G1|
|monoatomic ion homeostasis|8.56|SLC39A9,ATP6V0A2,ATP2C1,ANKH,CLCN3,CCDC22,ATP6V1G1|
|inorganic molecular entity transmembrane transporter activity|7.94|SLC39A11,SLC39A9,ATP6V0A2,ATP2C1,SLC25A28,ANKH,CLCN3,XPR1,ATP6V1G1|
|inorganic ion transmembrane transport|7.44|SLC39A11,SLC39A9,ATP6V0A2,ATP2C1,SLC25A28,ANKH,CLCN3,XPR1,ATP6V1G1|
|chemical homeostasis|6.39|SLC39A9,ATP6V0A2,PRKAA1,ATP2C1,ANKH,CLCN3,XPR1,CCDC22,ATP6V1G1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>