Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 [The Human Chemical-Genetic Interaction Map Project]

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====== Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 ======
==== Mechanism of Action ====
Microtubule stabilizer
  * **<color #00a2e8>Class / Subclass 1:</color>** Organelle Function / Cytoskeletal Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Cell Cycle / Microtubule Poison



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Epothilone D%%
    * **<color #00a2e8>Synonyms:</color>** KOS 862
    * **<color #00a2e8>CAS #:</color>** 189453-10-9
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/447865|447865]]
    * **<color #00a2e8>IUPAC:</color>** %%(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C27H41NO5S/c1-16-9-8-10-17(2)25(31)19(4)26(32)27(6,7)23(29)14-24(30)33-22(12-11-16)18(3)13-21-15-34-20(5)28-21/h11,13,15,17,19,22-23,25,29,31H,8-10,12,14H2,1-7H3/b16-11-,18-13+/t17-,19+,22-,23-,25-/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** XOZIUKBZLSUILX-GIQCAXHBSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 491.7
    * **<color #00a2e8>Canonical SMILES:</color>** CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@H]1CCC/C(=C\\C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C2=CSC(=N2)C)/C)/C
    * **<color #00a2e8>Molecular Formula:</color>** C27H41NO5S
{{:chemogenomics:structures:chem-0137.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** N/A
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Epithilone-D
    * **<color #00a2e8>Min:</color>** -6.7452; **<color #00a2e8>Max:</color>** 86.8600
{{:chemogenomics:dose_response:dr_214.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0027    |
| IC30  |0.0034    |
| IC40  |0.0041    |
| IC50  |0.0049    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 4-6nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.2
    * **<color #00a2e8>Numbers of reads</color>**: 19604237


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|2/2|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Epothilone_D_0.004-0.006day4uM_Round-5_exp232.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Epothilone-D 0.004 to 0.006μM on day4 R05 exp232'>
{{:chemogenomics:cranks_plots:exp232.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:K:KATNA1|KATNA1]]|-3.55|<0.01|
|[[:human_genes:T:TACC3|TACC3]]|-2.83|0.02|
|[[:human_genes:R:RSRC2|RSRC2]]|-2.60|0.41|
|[[:human_genes:G:GCLC|GCLC]]|-2.48|0.24|
|[[:human_genes:B:BUB1B|BUB1B]]|-2.34|0.24|
|[[:human_genes:S:SEPSECS|SEPSECS]]|-2.29|0.25|
|[[:human_genes:M:METTL20|METTL20]]|-2.28|0.24|
|[[:human_genes:Z:ZXDB|ZXDB]]|-2.26|0.24|
|[[:human_genes:Z:ZBED2|ZBED2]]|-2.25|0.45|
|[[:human_genes:A:ACTL6A|ACTL6A]]|-2.24|0.45|
|[[:human_genes:M:MGST1|MGST1]]|-2.24|0.24|
|[[:human_genes:R:RIC8A|RIC8A]]|-2.23|0.24|
|[[:human_genes:W:WDR62|WDR62]]|-2.21|0.24|
|[[:human_genes:E:EEF2|EEF2]]|-2.21|0.67|
|[[:human_genes:P:PIAS4|PIAS4]]|-2.16|0.25|
|[[:human_genes:C:CMC2|CMC2]]|-2.16|0.58|
|[[:human_genes:D:DMRTA2|DMRTA2]]|-2.14|0.25|
|[[:human_genes:C:CHMP6|CHMP6]]|-2.12|0.41|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.10|0.45|
|[[:human_genes:A:ALDH18A1|ALDH18A1]]|-2.09|0.41|
|[[:human_genes:K:KIF2A|KIF2A]]|-2.06|0.37|
|[[:human_genes:T:TRAPPC3|TRAPPC3]]|-2.05|0.37|
|[[:human_genes:D:DMP1|DMP1]]|-2.04|0.41|
|[[:human_genes:V:VRK1|VRK1]]|-2.03|0.41|
|[[:human_genes:Z:ZNF704|ZNF704]]|-2.03|0.41|
|[[:human_genes:A:ASPHD1|ASPHD1]]|-2.03|0.41|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.03|0.48|
|[[:human_genes:S:SERINC3|SERINC3]]|-2.02|0.48|
|[[:human_genes:P:PSTK|PSTK]]|-2.02|0.41|
|[[:human_genes:C:CD86|CD86]]|-1.98|0.45|
|[[:human_genes:C:CCDC116|CCDC116]]|1.98|0.50|
|[[:human_genes:B:BRINP2|BRINP2]]|1.99|0.43|
|[[:human_genes:K:KIAA1191|KIAA1191]]|1.99|0.43|
|[[:human_genes:C:CYB561A3|CYB561A3]]|2.01|0.47|
|[[:human_genes:D:DDT|DDT]]|2.01|0.43|
|[[:human_genes:P:POLR1A|POLR1A]]|2.01|0.68|
|[[:human_genes:Z:ZNF688|ZNF688]]|2.02|0.46|
|[[:human_genes:C:CCDC30|CCDC30]]|2.03|0.46|
|[[:human_genes:O:OTOF|OTOF]]|2.03|0.46|
|[[:human_genes:T:TRAPPC2L|TRAPPC2L]]|2.08|0.43|
|[[:human_genes:A:AQR|AQR]]|2.09|0.70|
|[[:human_genes:C:CDKL3|CDKL3]]|2.10|0.43|
|[[:human_genes:L:LRIG1|LRIG1]]|2.12|0.43|
|[[:human_genes:P:PSMD11|PSMD11]]|2.15|0.43|
|[[:human_genes:V:VASN|VASN]]|2.15|0.43|
|[[:human_genes:T:TPX2|TPX2]]|2.16|0.50|
|[[:human_genes:C:CLASP1|CLASP1]]|2.21|0.32|
|[[:human_genes:R:RAB44|RAB44]]|2.21|0.50|
|[[:human_genes:C:C11orf84|C11orf84]]|2.21|0.43|
|[[:human_genes:K:KPNA1|KPNA1]]|2.22|0.32|
|[[:human_genes:S:SCARF2|SCARF2]]|2.23|0.43|
|[[:human_genes:E:EXOSC9|EXOSC9]]|2.23|0.32|
|[[:human_genes:P:POLA1|POLA1]]|2.23|0.68|
|[[:human_genes:S:SUPT6H|SUPT6H]]|2.35|0.46|
|[[:human_genes:K:KLHL31|KLHL31]]|2.36|0.31|
|[[:human_genes:C:CEP192|CEP192]]|2.49|0.43|
|[[:human_genes:N:NUP160|NUP160]]|2.64|0.43|
|[[:human_genes:N:NDUFB7|NDUFB7]]|2.71|0.32|
|[[:human_genes:K:KLRC3|KLRC3]]|2.73|0.05|
|[[:human_genes:D:DDTL|DDTL]]|3.04|0.02|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|0.073|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|0.086|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|0.085|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|0.074|<button type="primary" size="small" modal="4">View</button>|
</modal>


<modal id="1" size="lg" title="Epothilone-D 0.004 to 0.006μM on day4 R05 exp232  vs  Ixabepilone 0.004 to 0.005μM on day4 R04 exp184">
{{:chemogenomics:comparison_plots:exp184_vs_exp232.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Cabazitaxel 0.001μM R05 exp223  vs  Epothilone-D 0.004 to 0.006μM on day4 R05 exp232">
{{:chemogenomics:comparison_plots:exp223_vs_exp232.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Epothilone-B 0.0015μM R05 exp231  vs  Epothilone-D 0.004 to 0.006μM on day4 R05 exp232">
{{:chemogenomics:comparison_plots:exp231_vs_exp232.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Docetaxel 0.001 to 0.002μM on day4 R04 exp159  vs  Epothilone-D 0.004 to 0.006μM on day4 R05 exp232">
{{:chemogenomics:comparison_plots:exp159_vs_exp232.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>