Bisphenol A 100μM R06 exp269 [The Human Chemical-Genetic Interaction Map Project]

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====== Bisphenol A 100μM R06 exp269 ======
==== Mechanism of Action ====
Widely-used in plastics and epoxy resins, endocrine disrupter
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Industrial Chemical




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Bisphenol A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 80-05-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/6623|6623]]
    * **<color #00a2e8>IUPAC:</color>** %%4-[2-(4-hydroxyphenyl)propan-2-yl]phenol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
    * **<color #00a2e8>INCHI Key:</color>** IISBACLAFKSPIT-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 228.29
    * **<color #00a2e8>Canonical SMILES:</color>** CC(C)(C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C15H16O2
{{:chemogenomics:structures:chem-0161.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich (Supelco)
    * **<color #00a2e8>Catalog #:</color>** 239658
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M-H)- Calcd for C15 H16 O2 227.10775; found 227.10823
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Bisphenol_A
    * **<color #00a2e8>Min:</color>** -16.3725; **<color #00a2e8>Max:</color>** 25.3053
{{:chemogenomics:dose_response:dr_282.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 100µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.0
    * **<color #00a2e8>Numbers of reads</color>**: 8455146


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|10/10|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Bisphenol_A_100uM_Round-6_exp269.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Bisphenol A 100μM R06 exp269'>
{{:chemogenomics:cranks_plots:exp269.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SCYL1|SCYL1]]|-3.78|<0.01|
|[[:human_genes:S:STMN1|STMN1]]|-3.35|<0.01|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-3.27|<0.01|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.98|0.01|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.76|0.03|
|[[:human_genes:Z:ZBTB48|ZBTB48]]|-2.73|0.02|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.67|0.02|
|[[:human_genes:S:SOX4|SOX4]]|-2.61|0.09|
|[[:human_genes:S:SPC24|SPC24]]|-2.50|0.59|
|[[:human_genes:C:CHMP7|CHMP7]]|-2.49|0.04|
|[[:human_genes:T:TCF4|TCF4]]|-2.48|0.04|
|[[:human_genes:I:ITGB1|ITGB1]]|-2.46|0.04|
|[[:human_genes:B:BIRC2|BIRC2]]|-2.46|0.09|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.41|0.06|
|[[:human_genes:P:PHACTR3|PHACTR3]]|-2.33|0.19|
|[[:human_genes:I:IFFO1|IFFO1]]|-2.32|0.09|
|[[:human_genes:A:ARL1|ARL1]]|-2.29|0.09|
|[[:human_genes:N:NUP88|NUP88]]|-2.27|0.09|
|[[:human_genes:T:TRAPPC2L|TRAPPC2L]]|-2.27|0.09|
|[[:human_genes:I:IFNAR2|IFNAR2]]|-2.27|0.13|
|[[:human_genes:I:INTS2|INTS2]]|-2.26|0.24|
|[[:human_genes:G:GPR107|GPR107]]|-2.23|0.10|
|[[:human_genes:R:RAB18|RAB18]]|-2.23|0.10|
|[[:human_genes:H:HOXB13|HOXB13]]|-2.23|0.10|
|[[:human_genes:O:OR52I1|OR52I1]]|-2.22|0.10|
|[[:human_genes:Y:YIPF5|YIPF5]]|-2.18|0.11|
|[[:human_genes:R:RGP1|RGP1]]|-2.17|0.30|
|[[:human_genes:D:DERL2|DERL2]]|-2.15|0.13|
|[[:human_genes:D:DHX30|DHX30]]|-2.15|0.43|
|[[:human_genes:V:VPS54|VPS54]]|-2.14|0.22|
|[[:human_genes:M:MSTO1|MSTO1]]|2.12|0.36|
|[[:human_genes:P:PTGES3|PTGES3]]|2.13|0.24|
|[[:human_genes:N:NPIPA5|NPIPA5]]|2.13|0.44|
|[[:human_genes:K:KTI12|KTI12]]|2.15|0.14|
|[[:human_genes:R:RPRD1B|RPRD1B]]|2.18|0.31|
|[[:human_genes:F:FAM58A|FAM58A]]|2.18|0.12|
|[[:human_genes:M:METTL1|METTL1]]|2.20|0.18|
|[[:human_genes:H:HIST1H2AK|HIST1H2AK]]|2.21|0.28|
|[[:human_genes:L:LRRC63|LRRC63]]|2.27|0.65|
|[[:human_genes:E:EIF2AK3|EIF2AK3]]|2.27|0.09|
|[[:human_genes:C:C12orf65|C12orf65]]|2.28|0.09|
|[[:human_genes:M:MBD3|MBD3]]|2.28|0.09|
|[[:human_genes:P:PGPEP1L|PGPEP1L]]|2.31|0.08|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|2.36|0.10|
|[[:human_genes:S:SLC7A1|SLC7A1]]|2.41|0.26|
|[[:human_genes:P:PPP3CA|PPP3CA]]|2.43|0.05|
|[[:human_genes:D:DPH1|DPH1]]|2.48|0.04|
|[[:human_genes:S:SLC25A32|SLC25A32]]|2.49|0.07|
|[[:human_genes:P:PUS3|PUS3]]|2.50|0.07|
|[[:human_genes:S:SMIM12|SMIM12]]|2.51|0.04|
|[[:human_genes:F:FKBPL|FKBPL]]|2.51|0.04|
|[[:human_genes:F:FDPS|FDPS]]|2.53|0.10|
|[[:human_genes:T:TRMT61A|TRMT61A]]|2.56|0.17|
|[[:human_genes:P:PPP6C|PPP6C]]|2.69|0.04|
|[[:human_genes:O:OXSM|OXSM]]|2.78|0.01|
|[[:human_genes:G:GPX4|GPX4]]|2.91|<0.01|
|[[:human_genes:K:KMT2D|KMT2D]]|2.93|<0.01|
|[[:human_genes:R:RBM26|RBM26]]|3.24|<0.01|
|[[:human_genes:W:WDR83|WDR83]]|3.49|<0.01|
|[[:human_genes:F:FAM98B|FAM98B]]|3.99|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.079|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.068|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.066|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.065|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp224|CB-839 10μM R05 exp224]]|0.065|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.064|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.063|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.062|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.061|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|0.061|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.059|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.059|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.055|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|0.054|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.052|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|0.051|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp275|Citral 75μM R06 exp275]]|0.051|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.051|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.075|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|0.07|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|0.054|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.051|<button type="primary" size="small" modal="22">View</button>|
</modal>


<modal id="1" size="lg" title="Bisphenol A 100μM R06 exp269  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp269_vs_exp445.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Bisphenol A 100μM R06 exp269  vs  FK-506 30μM R07 exp359">
{{:chemogenomics:comparison_plots:exp269_vs_exp359.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp269_vs_exp530.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp269_vs_exp466.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Bisphenol A 100μM R06 exp269  vs  CB-839 10μM R05 exp224">
{{:chemogenomics:comparison_plots:exp224_vs_exp269.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp269_vs_exp422.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Cannabidiol 13μM R08 exp465">
{{:chemogenomics:comparison_plots:exp269_vs_exp465.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Bisphenol A 100μM R06 exp269  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp269_vs_exp90.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Bisphenol F 50μM R08 exp457">
{{:chemogenomics:comparison_plots:exp269_vs_exp457.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Bisphenol A 100μM R06 exp269  vs  ETC-159 50μM R08 exp480">
{{:chemogenomics:comparison_plots:exp269_vs_exp480.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp269_vs_exp442.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp269_vs_exp344.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Bisphenol A 100μM R06 exp269  vs  EPZ-5676 30μM R05 exp233">
{{:chemogenomics:comparison_plots:exp233_vs_exp269.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Rapamycin 10μM R00 exp30">
{{:chemogenomics:comparison_plots:exp269_vs_exp30.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Bisphenol A 100μM R06 exp269  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp269_vs_exp85.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Salubrinal 20μM R07 exp399">
{{:chemogenomics:comparison_plots:exp269_vs_exp399.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Citral 75μM R06 exp275">
{{:chemogenomics:comparison_plots:exp269_vs_exp275.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Centrinone 0.5μM R07 exp343">
{{:chemogenomics:comparison_plots:exp269_vs_exp343.png?nolink |}}
</modal>

<modal id="19" size="lg" title="BVD-523 15μM R02 exp67  vs  Bisphenol A 100μM R06 exp269">
{{:chemogenomics:comparison_plots:exp269_vs_exp67.png?nolink |}}
</modal>

<modal id="20" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Bisphenol A 100μM R06 exp269">
{{:chemogenomics:comparison_plots:exp269_vs_exp334.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Amiloride 100μM R08 exp447  vs  Bisphenol A 100μM R06 exp269">
{{:chemogenomics:comparison_plots:exp269_vs_exp447.png?nolink |}}
</modal>

<modal id="22" size="lg" title="BS-181 20μM R08 exp461  vs  Bisphenol A 100μM R06 exp269">
{{:chemogenomics:comparison_plots:exp269_vs_exp461.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|tRNA processing|22.10|FAM98B,TRMT61A,PUS3,METTL1,KTI12|
</modal>