D-Fructose 10000μM R06 exp279 [The Human Chemical-Genetic Interaction Map Project]

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====== D-Fructose 10000μM R06 exp279 ======
==== Mechanism of Action ====
Monosaccharide
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Nutrient




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%D-(-)-Fructose%%
    * **<color #00a2e8>Synonyms:</color>** D(-?)?-?Fructose
    * **<color #00a2e8>CAS #:</color>** 57-48-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5984|5984]]
    * **<color #00a2e8>IUPAC:</color>** %%(3S,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3,5-9,11-12H,1-2H2/t3-,5-,6-/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** BJHIKXHVCXFQLS-UYFOZJQFSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 180.16
    * **<color #00a2e8>Canonical SMILES:</color>** C(C(C(C(C(=O)CO)O)O)O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C([C@H]([C@H]([C@@H](C(=O)CO)O)O)O)O
    * **<color #00a2e8>Molecular Formula:</color>** C6H12O6
{{:chemogenomics:structures:chem-0169.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** F3510
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C6H12O6 203.05261; found 203.05156
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** D-(-)-Fructose
    * **<color #00a2e8>Min:</color>** -9.9676; **<color #00a2e8>Max:</color>** 4.1860
{{:chemogenomics:dose_response:dr_201.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 10000µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.6
    * **<color #00a2e8>Numbers of reads</color>**: 7207885


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/D-Fructose_10000uM_Round-6_exp279.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='D-Fructose 10000μM R06 exp279'>
{{:chemogenomics:cranks_plots:exp279.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SNRPD3|SNRPD3]]|-2.59|0.88|
|[[:human_genes:G:GLRX2|GLRX2]]|-2.53|0.31|
|[[:human_genes:W:WBSCR16|WBSCR16]]|-2.41|0.82|
|[[:human_genes:S:SART3|SART3]]|-2.35|0.69|
|[[:human_genes:N:NDUFV1|NDUFV1]]|-2.24|0.69|
|[[:human_genes:N:NMNAT1|NMNAT1]]|-2.20|0.69|
|[[:human_genes:T:TNFSF12|TNFSF12]]|-2.13|0.69|
|[[:human_genes:A:ARRDC5|ARRDC5]]|-2.12|0.69|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.10|0.69|
|[[:human_genes:K:KIF2A|KIF2A]]|-2.09|0.69|
|[[:human_genes:M:MRPS16|MRPS16]]|-2.00|0.69|
|[[:human_genes:Z:ZNF614|ZNF614]]|-1.97|0.69|
|[[:human_genes:O:OR52E4|OR52E4]]|-1.97|0.69|
|[[:human_genes:R:RNASE7|RNASE7]]|-1.96|0.69|
|[[:human_genes:A:ACP1|ACP1]]|-1.95|0.69|
|[[:human_genes:P:PCDHB12|PCDHB12]]|-1.94|0.69|
|[[:human_genes:B:BBS7|BBS7]]|-1.93|0.69|
|[[:human_genes:S:STMN3|STMN3]]|-1.91|0.69|
|[[:human_genes:M:MYL5|MYL5]]|-1.91|0.69|
|[[:human_genes:Z:ZBED2|ZBED2]]|-1.90|0.96|
|[[:human_genes:F:FH|FH]]|-1.89|0.82|
|[[:human_genes:M:MTMR10|MTMR10]]|-1.88|0.69|
|[[:human_genes:K:KIAA1324L|KIAA1324L]]|-1.88|0.69|
|[[:human_genes:M:MAP3K13|MAP3K13]]|-1.87|0.69|
|[[:human_genes:P:PIGP|PIGP]]|-1.87|0.69|
|[[:human_genes:C:C17orf75|C17orf75]]|-1.87|0.69|
|[[:human_genes:C:CEPT1|CEPT1]]|-1.87|0.69|
|[[:human_genes:T:TBCA|TBCA]]|-1.86|0.69|
|[[:human_genes:T:TFEC|TFEC]]|-1.85|0.69|
|[[:human_genes:Z:ZNF317|ZNF317]]|-1.85|0.69|
|[[:human_genes:K:KRTAP9-9|KRTAP9-9]]|1.95|0.57|
|[[:human_genes:C:CST4|CST4]]|1.97|0.45|
|[[:human_genes:M:MYOM3|MYOM3]]|1.97|0.57|
|[[:human_genes:T:TNFRSF4|TNFRSF4]]|1.99|0.57|
|[[:human_genes:L:LINGO1|LINGO1]]|2.00|0.60|
|[[:human_genes:K:KIF11|KIF11]]|2.01|0.79|
|[[:human_genes:S:SPNS3|SPNS3]]|2.02|0.40|
|[[:human_genes:A:APOA4|APOA4]]|2.03|0.51|
|[[:human_genes:R:RASD1|RASD1]]|2.03|0.40|
|[[:human_genes:F:FAM84A|FAM84A]]|2.04|0.40|
|[[:human_genes:P:PRG2|PRG2]]|2.07|0.37|
|[[:human_genes:L:LRRC8E|LRRC8E]]|2.09|0.36|
|[[:human_genes:C:CTU2|CTU2]]|2.10|0.44|
|[[:human_genes:C:CALCOCO2|CALCOCO2]]|2.14|0.32|
|[[:human_genes:S:SLC10A7|SLC10A7]]|2.17|0.30|
|[[:human_genes:R:RNF14|RNF14]]|2.18|0.30|
|[[:human_genes:L:LRR1|LRR1]]|2.19|0.71|
|[[:human_genes:T:TRMT13|TRMT13]]|2.20|0.30|
|[[:human_genes:S:STX10|STX10]]|2.21|0.30|
|[[:human_genes:R:RBM22|RBM22]]|2.22|0.57|
|[[:human_genes:R:RPA1|RPA1]]|2.25|0.71|
|[[:human_genes:N:NFKB2|NFKB2]]|2.26|0.43|
|[[:human_genes:P:PSMC3|PSMC3]]|2.30|0.60|
|[[:human_genes:Z:ZNF335|ZNF335]]|2.31|0.53|
|[[:human_genes:D:DDX52|DDX52]]|2.31|0.30|
|[[:human_genes:S:SON|SON]]|2.32|0.30|
|[[:human_genes:P:PSMB4|PSMB4]]|2.39|0.35|
|[[:human_genes:H:H2AFJ|H2AFJ]]|2.48|0.30|
|[[:human_genes:T:TMEM144|TMEM144]]|2.50|0.18|
|[[:human_genes:P:PSMD12|PSMD12]]|3.18|0.18|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>