Glyphosate 1000μM R06 exp283 [The Human Chemical-Genetic Interaction Map Project]

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====== Glyphosate 1000μM R06 exp283 ======
==== Mechanism of Action ====
Inhibits 5-enolpyruvylshikimate-3-phosphate synthase, a.k.a Roundup
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Herbicide




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Glyphosate%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1071-83-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/3496|3496]]
    * **<color #00a2e8>IUPAC:</color>** %%2-(phosphonomethylamino)acetic acid%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C3H8NO5P/c5-3(6)1-4-2-10(7,8)9/h4H,1-2H2,(H,5,6)(H2,7,8,9)
    * **<color #00a2e8>INCHI Key:</color>** XDDAORKBJWWYJS-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 169.07
    * **<color #00a2e8>Canonical SMILES:</color>** C(C(=O)O)NCP(=O)(O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C3H8NO5P
{{:chemogenomics:structures:chem-0173.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich (Supelco)
    * **<color #00a2e8>Catalog #:</color>** 45521
    * **<color #00a2e8>Lot #:</color>** BCBS2439V
</panel>


<panel title='Compound Characterization' collapsed='true'>
Characterization data not available.
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Glyphosate
    * **<color #00a2e8>Min:</color>** 6.2675; **<color #00a2e8>Max:</color>** 36.0044
{{:chemogenomics:dose_response:dr_287.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 1000µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.4
    * **<color #00a2e8>Numbers of reads</color>**: 7456928


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Glyphosate_1000uM_Round-6_exp283.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="default" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Glyphosate 1000μM R06 exp283'>
{{:chemogenomics:cranks_plots:exp283.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SNF8|SNF8]]|-2.24|0.93|
|[[:human_genes:V:VARS|VARS]]|-2.16|0.93|
|[[:human_genes:N:NDUFB3|NDUFB3]]|-2.15|0.93|
|[[:human_genes:O:ODC1|ODC1]]|-2.11|0.93|
|[[:human_genes:R:RNASE1|RNASE1]]|-2.08|0.93|
|[[:human_genes:F:FAM163B|FAM163B]]|-2.06|0.93|
|[[:human_genes:M:MYCL|MYCL]]|-2.03|0.93|
|[[:human_genes:A:ARIH1|ARIH1]]|-2.02|0.93|
|[[:human_genes:R:RTCB|RTCB]]|-2.02|0.93|
|[[:human_genes:N:NDNL2|NDNL2]]|-1.99|0.93|
|[[:human_genes:A:ATP13A3|ATP13A3]]|-1.96|0.93|
|[[:human_genes:S:SLC4A7|SLC4A7]]|-1.96|0.93|
|[[:human_genes:D:DNAJC8|DNAJC8]]|-1.96|0.93|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-1.94|0.93|
|[[:human_genes:R:RAPGEF6|RAPGEF6]]|-1.94|0.93|
|[[:human_genes:C:COQ6|COQ6]]|-1.92|0.93|
|[[:human_genes:E:EMC1|EMC1]]|-1.91|0.93|
|[[:human_genes:C:CBFB|CBFB]]|-1.89|0.93|
|[[:human_genes:S:SNX4|SNX4]]|-1.89|0.93|
|[[:human_genes:K:KRTAP19-4|KRTAP19-4]]|-1.88|0.93|
|[[:human_genes:A:AKAP14|AKAP14]]|-1.86|0.93|
|[[:human_genes:V:VEZT|VEZT]]|-1.85|0.93|
|[[:human_genes:A:ATP8B2|ATP8B2]]|-1.85|0.93|
|[[:human_genes:T:TRPC1|TRPC1]]|-1.81|0.93|
|[[:human_genes:O:OR6B3|OR6B3]]|-1.81|0.93|
|[[:human_genes:U:U2AF1|U2AF1]]|-1.80|0.93|
|[[:human_genes:P:PITPNM3|PITPNM3]]|-1.80|0.93|
|[[:human_genes:E:ERCC2|ERCC2]]|-1.79|0.93|
|[[:human_genes:H:HRH1|HRH1]]|-1.79|0.93|
|[[:human_genes:D:DHPS|DHPS]]|-1.79|0.93|
|[[:human_genes:P:PROM1|PROM1]]|1.84|0.85|
|[[:human_genes:A:AURKB|AURKB]]|1.85|0.85|
|[[:human_genes:T:TLK2|TLK2]]|1.86|0.85|
|[[:human_genes:P:PSMB4|PSMB4]]|1.86|0.85|
|[[:human_genes:P:PRRC1|PRRC1]]|1.86|0.85|
|[[:human_genes:K:KRTAP5-7|KRTAP5-7]]|1.86|0.85|
|[[:human_genes:S:SKIV2L2|SKIV2L2]]|1.88|0.85|
|[[:human_genes:C:CLVS1|CLVS1]]|1.88|0.85|
|[[:human_genes:K:KIAA1467|KIAA1467]]|1.89|0.85|
|[[:human_genes:P:PSMD1|PSMD1]]|1.90|0.85|
|[[:human_genes:P:PARP3|PARP3]]|1.91|0.85|
|[[:human_genes:C:CECR2|CECR2]]|1.93|0.85|
|[[:human_genes:Z:ZNF718|ZNF718]]|1.94|0.85|
|[[:human_genes:R:RFC3|RFC3]]|1.94|0.85|
|[[:human_genes:I:ISY1|ISY1]]|1.94|0.85|
|[[:human_genes:C:C1orf56|C1orf56]]|1.96|0.85|
|[[:human_genes:C:CHEK2|CHEK2]]|1.97|0.85|
|[[:human_genes:M:MTHFD2|MTHFD2]]|1.99|0.85|
|[[:human_genes:S:SFSWAP|SFSWAP]]|2.02|0.85|
|[[:human_genes:W:WDR12|WDR12]]|2.02|0.85|
|[[:human_genes:Z:ZNF852|ZNF852]]|2.06|0.85|
|[[:human_genes:P:POLR2C|POLR2C]]|2.11|0.85|
|[[:human_genes:T:TXNIP|TXNIP]]|2.15|0.62|
|[[:human_genes:D:DTYMK|DTYMK]]|2.27|0.85|
|[[:human_genes:B:BTK|BTK]]|2.31|0.40|
|[[:human_genes:T:TSPAN10|TSPAN10]]|2.38|0.67|
|[[:human_genes:S:SMC1A|SMC1A]]|2.63|0.85|
|[[:human_genes:D:DCAF8|DCAF8]]|2.71|0.14|
|[[:human_genes:R:RPS16|RPS16]]|2.85|0.62|
|[[:human_genes:B:BYSL|BYSL]]|3.11|0.09|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
No correlation data above threshold. (correlation > 0.05)
</modal>


<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|rRNA processing|16.17|BYSL,RPS16,WDR12,MTREX,NOP10,RPS28|
|ribonucleoprotein complex biogenesis|10.30|BYSL,RPS16,WDR12,SFSWAP,ISY1,MTREX,NOP10,RPS28|
</modal>